Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CHE-14 protein | 0.0136 | 0.0314 | 0.0314 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0136 | 0.0314 | 0.0314 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0136 | 0.0314 | 0.0314 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.126 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2636 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 0.0314 | 0.0314 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0314 | 0.0314 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.033 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.126 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2636 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0136 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0155 | 0.126 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0136 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0136 | 0.0314 | 0.0314 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.033 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.2636 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.126 | 1 |
Schistosoma mansoni | patched 1 | 0.0136 | 0.0314 | 0.0314 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0136 | 0.0314 | 0.0314 |
Echinococcus multilocularis | protein dispatched 1 | 0.0136 | 0.0314 | 0.0314 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0136 | 0.0314 | 0.0314 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.32 | Calculated partition coefficient (clogP) | ChEMBL. | 1597859 |
clogP | = 3.7 | Calculated partition coefficient (clogP) | ChEMBL. | 1992149 |
IC50 (binding) | = 7.2 nM | Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver. | ChEMBL. | 1992149 |
IC50 (functional) | = 8 nM | Incorporation of [14C]- acetate into sterols measured in rat testis. | ChEMBL. | 1992149 |
IC50 (functional) | = 12 nM | Incorporation of [14C]- acetate into sterols measured in rat spleen. | ChEMBL. | 1992149 |
IC50 (functional) | = 34 nM | Incorporation of [14C]- acetate into sterols measured in rat liver. | ChEMBL. | 1992149 |
IC50 (binding) | = 0.007 uM | Tested in vitro for the inhibition of HMG-CoA reductase from partially purified microsomal preparations. | ChEMBL. | 1597859 |
IC50 ratio (functional) | = 0.24 | IC50 ratio evaluated as the IC50 values of testis to that of liver. | ChEMBL. | 1992149 |
IC50 ratio (functional) | = 0.35 | IC50 ratio evaluated as the IC50 values of spleen to that of liver. | ChEMBL. | 1992149 |
Inhibition (functional) | = 94 % | Tested in vivo for the inhibition of cholesterol biosynthesis in chow-fed rats at 1.0 mg/kg. | ChEMBL. | 1597859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.