Detailed information for compound 1077301

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.398 | Formula: C23H16N4O3
  • H donors: 1 H acceptors: 3 LogP: 2.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1nc2n(c3c1c1CCCn1c3C(=O)Nc1ccccc1)c(=O)c1c2cccc1
  • InChi: 1S/C23H16N4O3/c28-21-17-16-11-6-12-26(16)19(22(29)24-13-7-2-1-3-8-13)18(17)27-20(25-21)14-9-4-5-10-15(14)23(27)30/h1-5,7-10H,6,11-12H2,(H,24,29)
  • InChiKey: NKTZEWILDIYFCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi N-terminal motif family protein 0.0216 0.2954 0.3186
Brugia malayi MH1 domain containing protein 0.0044 0.0474 0.051
Giardia lamblia PHD finger protein 15 0.0031 0.0279 0.1448
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0901 1
Echinococcus granulosus tar DNA binding protein 0.0214 0.2923 0.2923
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0901 0.6758
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0901 0.1208
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0119 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0397 0.0426
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0451 0.0485
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0411 0.0411
Echinococcus granulosus peregrin 0.0031 0.0279 0.0279
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0882 0.1179
Schistosoma mansoni cpg binding protein 0.0031 0.0279 0.0198
Loa Loa (eye worm) hypothetical protein 0.0074 0.0901 0.097
Brugia malayi Smad1 0.0044 0.0474 0.051
Echinococcus multilocularis musashi 0.0028 0.0235 0.0235
Leishmania major hypothetical protein, conserved 0.0074 0.0901 0.6758
Brugia malayi hypothetical protein 0.004 0.0411 0.0442
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0235 0.0252
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0216 0.2954 0.9069
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0474 0.0474
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0901 0.1208
Brugia malayi MH2 domain containing protein 0.0652 0.9267 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0411 0.0411
Plasmodium falciparum amino acid transporter, putative 0.004 0.0411 0.6476
Loa Loa (eye worm) nuclear factor I 0.0025 0.0187 0.02
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0411 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0549 0.3753
Brugia malayi RNA recognition motif domain containing protein 0.0214 0.2923 0.3153
Schistosoma mansoni hypothetical protein 0.0051 0.0571 0.0492
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0411 0.0331
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0451 0.2921
Echinococcus granulosus intermediate filament protein 0.0028 0.0235 0.0235
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0571 0.0571
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.2168 0.2338
Mycobacterium tuberculosis Conserved protein 0.0074 0.0901 0.1208
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0279 0.0299
Echinococcus multilocularis GPCR, family 2 0.0051 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0901 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.128 0.138
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0279 0.0279
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0901 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0109 0.1178
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0416 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.002 0.0119 0.0119
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0411 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0451 0.2921
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0901 0.6758
Schistosoma mansoni tar DNA-binding protein 0.0214 0.2923 0.2864
Brugia malayi beta-lactamase family protein 0.0074 0.0901 0.097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.2168 0.2338
Mycobacterium tuberculosis Conserved protein 0.0074 0.0901 0.1208
Loa Loa (eye worm) hypothetical protein 0.0074 0.0901 0.097
Schistosoma mansoni tar DNA-binding protein 0.0214 0.2923 0.2864
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0279 0.2142
Schistosoma mansoni smad 0.002 0.0119 0.0036
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.128 0.138
Giardia lamblia Kinase, PLK 0.01 0.128 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.1296 0.1296
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.3813
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0411 0.0411
Loa Loa (eye worm) beta-lactamase 0.0074 0.0901 0.097
Schistosoma mansoni hypothetical protein 0.0051 0.0571 0.0492
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0571 0.0571
Plasmodium falciparum glutathione reductase 0.0055 0.0633 1
Echinococcus multilocularis peregrin 0.0031 0.0279 0.0279
Schistosoma mansoni smad1 5 8 and 0.0044 0.0474 0.0395
Loa Loa (eye worm) MH2 domain-containing protein 0.0652 0.9267 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0901 0.097
Schistosoma mansoni hypothetical protein 0.0051 0.0571 0.0492
Brugia malayi MH1 domain containing protein 0.0025 0.0187 0.02
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0571 0.0571
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0571 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0901 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0236 0.3245 0.35
Brugia malayi TAR-binding protein 0.0214 0.2923 0.3153
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0474 0.051
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.128 1
Plasmodium falciparum thioredoxin reductase 0.0055 0.0633 1
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0633 0.447
Brugia malayi RNA binding protein 0.0214 0.2923 0.3153
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0451 0.7117
Brugia malayi MH2 domain containing protein 0.0044 0.0474 0.051
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.1659 0.2365
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0882 0.0806
Schistosoma mansoni smad1 5 8 and 0.0044 0.0474 0.0395
Echinococcus multilocularis serotonin transporter 0.0236 0.3245 0.3245
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.128 0.3715
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0451 0.0522
Echinococcus multilocularis lamin dm0 0.0028 0.0235 0.0235
Schistosoma mansoni Smad4 0.0044 0.0474 0.0395
Treponema pallidum sodium- and chloride- dependent transporter 0.0236 0.3245 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0235 0.0252
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0373 0.0373
Schistosoma mansoni lamin 0.0028 0.0235 0.0153
Brugia malayi hypothetical protein 0.0077 0.0947 0.102
Brugia malayi beta-lactamase 0.0074 0.0901 0.097
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0901 0.6758
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0411 0.0411
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0633 0.7013
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0755 0.0813
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.128 0.128
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0882 0.0882
Echinococcus granulosus GPCR family 2 0.0051 0.0571 0.0571
Loa Loa (eye worm) hypothetical protein 0.0051 0.0571 0.0614
Brugia malayi jmjC domain containing protein 0.0101 0.1296 0.1397
Echinococcus multilocularis lamin 0.0028 0.0235 0.0235
Plasmodium vivax hypothetical protein, conserved 0.004 0.0411 0.4542
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0397 0.0397
Brugia malayi glutathione reductase 0.0055 0.0633 0.0681
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0161 0.2168 0.2338
Onchocerca volvulus 0.0074 0.0901 0.2501
Onchocerca volvulus Alhambra homolog 0.0031 0.0279 0.0511
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0411 0.0411
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.2082 0.2082
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0882 0.0806
Onchocerca volvulus 0.004 0.0411 0.0934
Echinococcus multilocularis smad 0.0044 0.0474 0.0474
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0901 0.6758
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0025 0.0187 0.02
Loa Loa (eye worm) glutathione reductase 0.0055 0.0633 0.0681
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.128 0.128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.2082 0.2082
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0411 0.0331
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0901 0.6758
Entamoeba histolytica hypothetical protein 0.0077 0.0947 0.5975
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0411 0.0331
Brugia malayi CXXC zinc finger family protein 0.0029 0.0255 0.0273
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.6661 1
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0451 0.2921
Onchocerca volvulus 0.0028 0.0235 0.0371
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.1863 0.2676
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0397 0.0317
Schistosoma mansoni tar DNA-binding protein 0.0214 0.2923 0.2864
Loa Loa (eye worm) hypothetical protein 0.0074 0.0901 0.097
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0227 0.0244
Plasmodium vivax amine transporter, putative 0.004 0.0411 0.4542
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0109 0.0109
Toxoplasma gondii hypothetical protein 0.004 0.0411 0.3813
Loa Loa (eye worm) RNA binding protein 0.0214 0.2923 0.3153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0633 0.6623
Brugia malayi MH2 domain containing protein 0.002 0.0119 0.0126
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0451 0.4991
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0901 0.1208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0155 0.2082 0.2245
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0107 0.0113
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0411 0.0411
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0035 0.0036
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.1659 0.2365
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0451 0.0451
Leishmania major trypanothione reductase 0.0055 0.0633 0.447
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0411 0.0411
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0119 0.0126
Schistosoma mansoni jumonji domain containing protein 0.008 0.0995 0.092
Loa Loa (eye worm) serotonin transporter b 0.0236 0.3245 0.35
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0549 0.3753
Schistosoma mansoni ap endonuclease 0.0043 0.0451 0.0372
Schistosoma mansoni hypothetical protein 0.011 0.1428 0.1357
Loa Loa (eye worm) solute carrier family 6 member 4 0.0236 0.3245 0.35
Echinococcus multilocularis tar DNA binding protein 0.0214 0.2923 0.2923
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.1659 0.2365
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0411 0.0411
Brugia malayi Bromodomain containing protein 0.0031 0.0279 0.0299
Toxoplasma gondii thioredoxin reductase 0.0055 0.0633 0.6615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0882 0.9761
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.1863 1
Echinococcus granulosus smad 0.0044 0.0474 0.0474
Echinococcus granulosus mothers against decapentaplegic 2 0.002 0.0119 0.0119
Mycobacterium ulcerans beta-lactamase 0.0074 0.0901 1
Loa Loa (eye worm) norepinephrine transporter 0.0236 0.3245 0.35
Schistosoma mansoni kinase 0.0051 0.0568 0.0489
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0901 0.0901
Onchocerca volvulus 0.004 0.0411 0.0934
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0882 0.6597
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.3813
Entamoeba histolytica hypothetical protein 0.0077 0.0947 0.5975
Brugia malayi Thioredoxin reductase 0.0055 0.0633 0.0681
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0451 0.1091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.2082 0.2082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0571 0.0571
Trypanosoma brucei trypanothione reductase 0.0055 0.0633 0.447
Brugia malayi intermediate filament protein 0.0028 0.0235 0.0252
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0451 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Echinococcus granulosus lamin 0.0028 0.0235 0.0235
Brugia malayi beta-lactamase family protein 0.0074 0.0901 0.097
Schistosoma mansoni Smad4 0.002 0.0119 0.0036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0901 0.1208
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.0442
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.1863 0.2676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.2168 0.2338
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0109 0.1679
Onchocerca volvulus 0.004 0.0411 0.0934
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0173
Mycobacterium ulcerans hypothetical protein 0.0074 0.0901 1
Schistosoma mansoni hypothetical protein 0.0031 0.0279 0.0197
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.0442
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0901 0.6758
Entamoeba histolytica hypothetical protein 0.0077 0.0947 0.5975
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.128 1
Echinococcus granulosus lamin dm0 0.0028 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0126
Plasmodium falciparum glutathione reductase 0.0019 0.0109 0.1679
Echinococcus granulosus mothers against decapentaplegic 6 0.002 0.0119 0.0119
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0279 0.2142
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0882 0.9761
Onchocerca volvulus 0.0074 0.0901 0.2501
Loa Loa (eye worm) Smad1 0.0044 0.0474 0.051
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.3813
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0035 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0235 0.0252
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.1296 0.1296
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0451 0.0485
Mycobacterium ulcerans lipase LipD 0.0074 0.0901 1
Plasmodium falciparum transporter, putative 0.004 0.0411 0.6476
Toxoplasma gondii ABC1 family protein 0.0074 0.0901 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0451 0.2921
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0109 0.1178
Plasmodium falciparum phd finger protein, putative 0.0031 0.0279 0.4374
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0474 0.0474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.2082 0.2016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0633 0.0799
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0474 0.0395
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0236 0.3245 0.3188
Loa Loa (eye worm) hypothetical protein 0.0216 0.2954 0.3186
Echinococcus granulosus serotonin transporter 0.0236 0.3245 0.3245
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.0074 0.0901 0.097
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0411 0.0331
Loa Loa (eye worm) hypothetical protein 0.011 0.1428 0.154
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0571 0.0614
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Loa Loa (eye worm) hypothetical protein 0.0236 0.3245 0.35
Brugia malayi jmjC domain containing protein 0.0039 0.0397 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.2082 0.2082
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0411 0.0411
Brugia malayi PHD-finger family protein 0.0031 0.0279 0.0299
Plasmodium vivax glutathione reductase, putative 0.0055 0.0633 0.7013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0018
Mycobacterium tuberculosis Probable reductase 0.0126 0.1659 0.2365
Onchocerca volvulus 0.0074 0.0901 0.2501
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0109 0.0116
Schistosoma mansoni lamin 0.0028 0.0235 0.0153
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0901 0.6758
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Loa Loa (eye worm) TAR-binding protein 0.0214 0.2923 0.3153
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0474 0.051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.1659 0.7881
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0451 0.4323
Entamoeba histolytica hypothetical protein 0.0077 0.0947 0.5975
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0411 0.0442
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0048 0.0049
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0279 0.0279
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0109 0.1679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0729 0.0652
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0411 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0411 0.0331
Loa Loa (eye worm) hypothetical protein 0.0053 0.0598 0.0644
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0411 0.0411
Brugia malayi mothers against decapentaplegic homolog 3 0.002 0.0119 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0214 0.2923 0.3153
Brugia malayi MH2 domain containing protein 0.0044 0.0474 0.051
Schistosoma mansoni smad1 5 8 and 0.0044 0.0474 0.0395
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0048 0.0049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0451 0.2921
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0901 0.0825
Schistosoma mansoni intermediate filament proteins 0.0028 0.0235 0.0153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0901 0.097
Trichomonas vaginalis esterase, putative 0.0074 0.0901 0.6758
Toxoplasma gondii exonuclease III APE 0.0043 0.0451 0.4323
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0901 0.1208
Loa Loa (eye worm) hypothetical protein 0.0013 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0077 0.0947 0.0871
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0411 0.0331
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.0442
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0901 0.1208
Echinococcus granulosus cpg binding protein 0.0031 0.0279 0.0279
Schistosoma mansoni serine/threonine protein kinase 0.01 0.128 0.1207
Loa Loa (eye worm) hypothetical protein 0.0074 0.0901 0.097
Schistosoma mansoni hypothetical protein 0.0051 0.0571 0.0492
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.1659 0.2365
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.1659 0.2365
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0454 0.0454
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.0442
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0026 0.0026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0451 0.0451
Trypanosoma brucei polo-like protein kinase 0.01 0.128 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.2082 0.2016
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.128 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0901 0.0825
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0155 0.2082 0.2245
Schistosoma mansoni sodium/chloride dependent transporter 0.0236 0.3245 0.3188
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0411 0.0331
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0411 0.0331
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0235 0.0252
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0474 0.0474
Brugia malayi MH1 domain containing protein 0.0025 0.0187 0.02
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0633 0.0633
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0633 0.0633
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0109 0.0027
Loa Loa (eye worm) hypothetical protein 0.0236 0.3245 0.35
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0901 0.6758
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0397 0.0317
Echinococcus multilocularis Smad4 0.0044 0.0474 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0882 0.9761
Schistosoma mansoni cpg binding protein 0.0031 0.0279 0.0198
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0571 0.0614
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0255 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0214 0.2923 0.2864
Loa Loa (eye worm) hypothetical protein 0.004 0.0411 0.0442
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0109 0.0109
Echinococcus multilocularis mothers against decapentaplegic 6 0.002 0.0119 0.0119
Onchocerca volvulus 0.0029 0.0255 0.0435
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0451 0.2921
Schistosoma mansoni Smad4 0.002 0.0119 0.0036
Schistosoma mansoni ap endonuclease 0.0043 0.0451 0.0372
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0633 0.0681
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0411 0.0331
Toxoplasma gondii hypothetical protein 0.004 0.0411 0.3813
Loa Loa (eye worm) hypothetical protein 0.0074 0.0901 0.097
Schistosoma mansoni smad 0.0044 0.0474 0.0395
Onchocerca volvulus 0.0236 0.3245 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0901 0.1208
Echinococcus multilocularis cpg binding protein 0.0031 0.0279 0.0279
Mycobacterium tuberculosis Conserved protein 0.0074 0.0901 0.1208
Schistosoma mansoni tar DNA-binding protein 0.0214 0.2923 0.2864
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0279 0.0197
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0279 0.3068
Onchocerca volvulus 0.0028 0.0235 0.0371
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.128 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.2082 0.2016
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0474 0.0474
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0947 0.0871
Loa Loa (eye worm) transcription factor SMAD2 0.0652 0.9267 1
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.1428 0.154
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0451 0.2921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0882 0.9761
Echinococcus granulosus Smad4 0.0044 0.0474 0.0474
Brugia malayi MH1 domain containing protein 0.0044 0.0474 0.051
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.1863 0.2676
Trichomonas vaginalis CAMK family protein kinase 0.01 0.128 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.0109 0.1679
Loa Loa (eye worm) hypothetical protein 0.0031 0.0279 0.0299
Loa Loa (eye worm) hypothetical protein 0.0236 0.3245 0.35
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0411 0.0442

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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