Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Glucose rise (functional) | = 67 mg dl-1 | Rise in the blood glucose level after 0 min following 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Glucose rise (functional) | = 85 mg dl-1 | Rise in the glucose level 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Glucose rise (functional) | = 152 mg dl-1 | Rise in the blood glucose level after 30 min following 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Inhibition (functional) | = -29 % | Percent inhibition of glucose rise, following 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.