Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0253 | 0.4945 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4945 | 0.4945 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0253 | 0.4945 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4945 | 0.4945 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.048 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.048 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.048 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0226 | 0.4339 | 0.4276 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0226 | 0.4339 | 0.4276 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.048 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0226 | 0.4339 | 0.4339 |
Brugia malayi | nuclear hormone receptor | 0.048 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.048 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0253 | 0.4945 | 0.485 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4945 | 0.4945 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0226 | 0.4339 | 0.4232 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.048 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0226 | 0.4339 | 0.4276 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0055 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.048 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.048 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0226 | 0.4339 | 0.4232 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0055 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0226 | 0.4339 | 0.4276 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | zinc finger protein | 0.0226 | 0.4339 | 0.4232 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.048 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0253 | 0.4945 | 0.4889 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0109 | 0.0109 |
Brugia malayi | nuclear receptor RXR | 0.0253 | 0.4945 | 0.4889 |
Brugia malayi | nuclear receptor NHR-88 | 0.048 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.048 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0226 | 0.4339 | 0.4232 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.048 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0226 | 0.4339 | 0.4232 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0253 | 0.4945 | 0.4945 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0226 | 0.4339 | 0.4339 |
Schistosoma mansoni | coup transcription factor | 0.048 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.048 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4945 | 0.4945 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0226 | 0.4339 | 0.4276 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0253 | 0.4945 | 0.4889 |
Brugia malayi | conserved hypotetical protein | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | thyroid hormone receptor | 0.048 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.4945 | 0.4945 |
Schistosoma mansoni | nuclear hormone receptor | 0.0226 | 0.4339 | 0.4232 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.048 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.048 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.048 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.048 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0226 | 0.4339 | 0.4339 |
Echinococcus multilocularis | FTZ F1 alpha | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0226 | 0.4339 | 0.4339 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0253 | 0.4945 | 0.4889 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.048 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.048 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | nuclear receptor | 0.0226 | 0.4339 | 0.4232 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.048 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.048 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.048 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.048 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0253 | 0.4945 | 0.4889 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0226 | 0.4339 | 0.4276 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0226 | 0.4339 | 0.4276 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.048 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.048 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Schistosoma mansoni | nuclear hormone receptor | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0226 | 0.4339 | 0.4276 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.048 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.048 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0226 | 0.4339 | 0.4276 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0226 | 0.4339 | 0.4276 |
Brugia malayi | tailless protein | 0.0226 | 0.4339 | 0.4276 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.048 | 1 | 1 |
Onchocerca volvulus | 0.048 | 1 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.048 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0226 | 0.4339 | 0.4232 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0226 | 0.4339 | 0.4276 |
Echinococcus granulosus | FTZ F1 alpha | 0.048 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0226 | 0.4339 | 0.4276 |
Brugia malayi | hypothetical protein | 0.0226 | 0.4339 | 0.4276 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.4339 | 0.4339 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.048 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.048 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.048 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0253 | 0.4945 | 0.485 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Glucose rise (functional) | = 68 mg dl-1 | Rise in the blood glucose level after 0 min following 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Glucose rise (functional) | = 77 mg dl-1 | Rise in the glucose level 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Glucose rise (functional) | = 145 mg dl-1 | Rise in the blood glucose level after 30 min following 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Inhibition (functional) | = -14 % | Percent inhibition of glucose rise, following 100 mg/kg oral dose in fasted nondiabetic rats | ChEMBL. | 2769683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.