Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1222 | 0.1402 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0193 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0193 | 0.0221 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0805 | 0.3342 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.1113 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0193 | 0.0221 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.006 | 0.0749 | 0.0996 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0071 | 0.1008 | 0.1342 |
Brugia malayi | Pre-SET motif family protein | 0.006 | 0.0749 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0548 | 0.0629 |
Brugia malayi | Pre-SET motif family protein | 0.0417 | 0.8715 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0193 | 0.2578 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0193 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0805 | 0.1071 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0805 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0193 | 0.0221 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0093 | 0.4829 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0193 | 0.0193 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0193 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.019 | 0.0453 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.019 | 0.0217 |
Trypanosoma cruzi | ISWI complex protein | 0.003 | 0.0093 | 0.4829 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0034 | 0.0171 | 0.0366 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0071 | 0.1008 | 0.1342 |
Plasmodium vivax | SET domain protein, putative | 0.006 | 0.0749 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0193 | 0.2578 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0193 | 0.0257 |
Echinococcus granulosus | zinc finger protein | 0.0039 | 0.0283 | 0.0377 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0119 | 0.2063 | 0.2746 |
Brugia malayi | Bromodomain containing protein | 0.0149 | 0.2742 | 0.3146 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.2552 | 0.2928 |
Schistosoma mansoni | bromodomain containing protein | 0.0126 | 0.2222 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0363 | 0.7512 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0193 | 0.0221 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0805 | 0.0923 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0193 | 0.0193 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0035 | 0.0198 | 0.0227 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0041 | 0.033 | 0.0378 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0094 | 0.1505 | 0.2003 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0548 | 0.0629 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0193 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0193 | 0.0221 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0193 | 0.0193 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0034 | 0.0171 | 0.0228 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0034 | 0.0171 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0193 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.019 | 0.0217 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0805 | 0.3342 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0193 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0548 | 0.0629 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0193 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1117 | 0.1281 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0045 | 0.0415 | 0.0552 |
Schistosoma mansoni | zinc finger protein | 0.0039 | 0.0283 | 0.0891 |
Onchocerca volvulus | 0.006 | 0.0749 | 0.0567 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0193 | 0.0221 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0805 | 0.0923 |
Echinococcus multilocularis | zinc finger protein | 0.0039 | 0.0283 | 0.0377 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0193 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.006 | 0.0749 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0805 | 0.3342 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0193 | 0.0193 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0094 | 0.1505 | 0.6633 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0193 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0094 | 0.1505 | 0.2003 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0805 | 0.0923 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0805 | 0.0923 |
Brugia malayi | PHD-finger family protein | 0.005 | 0.052 | 0.0596 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0193 | 0.0221 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0058 | 0.0699 | 0.0931 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0193 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0548 | 0.0629 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0805 | 0.0923 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.006 | 0.0749 | 0.3079 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0045 | 0.0415 | 0.151 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0193 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0193 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.4388 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0045 | 0.0415 | 0.0552 |
Trypanosoma brucei | ISWI complex protein | 0.003 | 0.0093 | 0.4829 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.06 | 0.238 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0193 | 0.0221 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0417 | 0.8715 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0193 | 0.0193 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.033 | 0.1112 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.006 | 0.0749 | 0.3079 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0193 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1505 | 0.1727 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0805 | 0.3342 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0094 | 0.1505 | 0.6633 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.1306 | 0.1499 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0193 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0193 | 0.0221 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0193 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.06 | 0.0688 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0805 | 0.0923 |
Trypanosoma cruzi | ISWI complex protein | 0.003 | 0.0093 | 0.4829 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0193 | 0.0469 |
Onchocerca volvulus | 0.0053 | 0.06 | 0.0415 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0193 | 0.0469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0805 | 0.3342 |
Echinococcus granulosus | tumor protein p63 | 0.0363 | 0.7512 | 1 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0034 | 0.0171 | 0.0228 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0119 | 0.2063 | 0.2746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.