Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0056 | 0.3681 | 0.3681 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0016 | 0.0855 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.3681 | 0.43 |
Schistosoma mansoni | ap endonuclease | 0.0016 | 0.0855 | 0.0998 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0032 | 0.1955 | 0.1955 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0009 | 0.0303 | 0.0353 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0032 | 0.1955 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0123 | 0.856 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0012 | 0.0516 | 0.0516 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0009 | 0.0303 | 0.0353 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0012 | 0.0516 | 0.1833 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0244 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0387 | 0.0387 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0009 | 0.0303 | 0.0303 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0032 | 0.1955 | 0.1955 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0016 | 0.0855 | 0.0855 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0009 | 0.0303 | 0.0353 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.765 | 0.8937 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0032 | 0.1955 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0009 | 0.0303 | 0.0303 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | ap endonuclease | 0.0016 | 0.0855 | 0.0998 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0032 | 0.1955 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.214 | 0.25 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | nuclear receptor NHR-88 | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.1955 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.1955 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0016 | 0.0855 | 0.0855 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0009 | 0.0303 | 0.0303 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0016 | 0.0855 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0009 | 0.0303 | 0.0303 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0244 | 0.0244 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0009 | 0.0303 | 0.0353 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.3681 | 0.43 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.1955 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.2006 | 0.2344 |
Trypanosoma brucei | glucosidase, putative | 0.0032 | 0.1955 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.3681 | 0.43 |
Brugia malayi | steroid hormone receptor | 0.0009 | 0.0303 | 0.0303 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0009 | 0.0303 | 0.0303 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0009 | 0.0303 | 0.0303 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0012 | 0.0516 | 0.0399 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0016 | 0.0855 | 0.2354 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0016 | 0.0855 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0032 | 0.1955 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0009 | 0.0303 | 0.0353 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | alpha-glucosidase | 0.0123 | 0.856 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.214 | 0.214 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0012 | 0.0516 | 0.1833 |
Schistosoma mansoni | nuclear hormone receptor | 0.0009 | 0.0303 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0516 | 0.0516 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0032 | 0.1955 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0032 | 0.1955 | 0.1955 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0016 | 0.0855 | 0.3756 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.3681 | 0.43 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.0303 | 0.0353 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.3681 | 0.43 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0032 | 0.1955 | 0.1955 |
Loa Loa (eye worm) | RNA binding protein | 0.0056 | 0.3681 | 0.3681 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0009 | 0.0303 | 0.0303 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0032 | 0.1955 | 0.3388 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0016 | 0.0855 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0244 | 0.0244 |
Brugia malayi | ecdysteroid receptor | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0012 | 0.0516 | 0.1833 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0009 | 0.0303 | 0.0353 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Echinococcus multilocularis | tar DNA binding protein | 0.0056 | 0.3681 | 0.3681 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0016 | 0.0855 | 0.2354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0009 | 0.0303 | 0.0303 |
Onchocerca volvulus | 0.0083 | 0.5641 | 1 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0119 | 0.8291 | 0.8291 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.011 | 0.765 | 0.765 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.011 | 0.765 | 0.765 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0012 | 0.0516 | 0.1833 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0009 | 0.0303 | 0.0303 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0016 | 0.0855 | 0.2354 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0009 | 0.0303 | 0.0303 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.4104 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0016 | 0.0855 | 0.2354 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0012 | 0.0516 | 0.1833 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0012 | 0.0516 | 0.1833 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0016 | 0.0855 | 0.2354 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0016 | 0.0855 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.1955 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0012 | 0.0516 | 0.1833 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0303 | 0.0303 |
Brugia malayi | TAR-binding protein | 0.0056 | 0.3681 | 0.3681 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0016 | 0.0855 | 0.0855 |
Schistosoma mansoni | alpha glucosidase | 0.0032 | 0.1955 | 0.2284 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.214 | 0.214 |
Onchocerca volvulus | 0.0032 | 0.2006 | 0.3191 | |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0016 | 0.0855 | 0.0855 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0244 | 0.0244 |
Echinococcus granulosus | tar DNA binding protein | 0.0056 | 0.3681 | 0.3681 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0244 | 0.0244 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.1955 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0009 | 0.0303 | 0.0303 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0012 | 0.0516 | 0.1833 |
Schistosoma mansoni | coup transcription factor | 0.0009 | 0.0303 | 0.0353 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.2006 | 0.2006 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0032 | 0.1955 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0009 | 0.0303 | 0.0353 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0032 | 0.1955 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0119 | 0.8291 | 0.9686 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0032 | 0.1955 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0016 | 0.0855 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.2006 | 0.2006 |
Loa Loa (eye worm) | TAR-binding protein | 0.0056 | 0.3681 | 0.3681 |
Echinococcus granulosus | FTZ F1 alpha | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0009 | 0.0303 | 0.0353 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0056 | 0.3681 | 0.3681 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0056 | 0.3681 | 0.3681 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0009 | 0.0303 | 0.0303 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0016 | 0.0855 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0009 | 0.0303 | 0.0303 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0032 | 0.1955 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0016 | 0.0855 | 0.3756 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0387 | 0.0387 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0009 | 0.0303 | 0.0303 |
Schistosoma mansoni | thyroid hormone receptor | 0.0119 | 0.8291 | 0.9686 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.214 | 0.25 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0387 | 0.0387 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0069 | 0.4635 | 0.5415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -1 % | Agonist activity at Agrobacterium tumefaciens WCF (pCF372) TraR assessed as activation of quorum sensing at 10 uM relative to OOHL | ChEMBL. | 21798749 |
Activity (functional) | = 0 % | Agonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as activation of quorum sensing at 10 uM relative to N-(3-oxo)-dodecanoyl HL | ChEMBL. | 21798749 |
Activity (functional) | = 6 % | Agonist activity at Vibrio fischeri ESI 114 (delta-LuxI) LuxR assessed as activation of quorum sensing at 10 uM relative to OHHL | ChEMBL. | 21798749 |
Inhibition (functional) | = -39 % | Antagonist activity at Vibrio fischeri ESI 114 (delta-LuxI) LuxR assessed as inhibition of OHHL-induced quorum sensing activation at 10 uM relative to untreated control | ChEMBL. | 21798749 |
Inhibition (functional) | = -6 % | Antagonist activity at Agrobacterium tumefaciens WCF (pCF372) TraR assessed as inhibition of OOHL-induced quorum sensing activation at 10 uM relative to untreated control | ChEMBL. | 21798749 |
Inhibition (functional) | = 8 % | Antagonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as inhibition of N-(3-oxo)-dodecanoyl HL-induced quorum sensing activation at 10 uM relative to untreated control | ChEMBL. | 21798749 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.