Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0954 | 0.1078 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0062 | 0.2948 | 0.8824 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.885 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0401 | 0.0453 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0401 | 0.0401 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0954 | 0.1916 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0401 | 0.0401 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.0401 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0068 | 0.3288 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.0401 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0068 | 0.3288 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Onchocerca volvulus | 0.0012 | 0.0061 | 0.0069 | |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.6997 | 0.6997 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0061 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1192 | 0.1192 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0401 | 0.0401 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0061 | 0.0069 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1192 | 0.1192 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1192 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3302 | 0.3731 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0401 | 0.0401 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5121 | 0.5786 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0061 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1192 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0061 | 0.0069 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0082 | 0.0082 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.6997 | 0.7907 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1192 | 0.1347 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0401 | 0.0401 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0012 | 0.0061 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1192 | 0.1192 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1192 | 0.1192 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0401 | 0.0401 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0012 | 0.0061 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0394 | 0.0445 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0401 | 0.0401 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0082 | 0.0082 |
Brugia malayi | hypothetical protein | 0.0164 | 0.885 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.0401 | 0.0453 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.0401 | 0.0453 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0053 | 0.245 | 0.7098 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.686 | 0.7752 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0954 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.686 | 0.7752 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0954 | 0.1078 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.0401 | 0.0401 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.0401 | 0.0453 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0401 | 0.0453 |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0401 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0061 | 0.0069 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.0401 | 0.0401 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1192 | 0.1192 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1192 | 0.1192 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.6997 | 0.6997 |
Leishmania major | cathepsin L-like protease | 0.0068 | 0.3288 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1192 | 0.1192 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.3302 | 0.3731 |
Onchocerca volvulus | 0.0164 | 0.885 | 1 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.6997 | 0.7907 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1192 | 0.1347 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.6997 | 0.6997 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0954 | 0.1916 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.6997 | 0.6997 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.6997 | 0.6997 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0954 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.3302 | 0.3302 |
Leishmania major | cathepsin L-like protease | 0.0068 | 0.3288 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.686 | 0.7752 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1192 | 0.1192 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0068 | 0.3288 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0401 | 0.0401 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1192 | 0.1192 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0401 | 0.0453 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1192 | 0.1192 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.0401 | 0.0453 |
Leishmania major | cathepsin L-like protease | 0.0068 | 0.3288 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.0401 | 0.0453 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.6997 | 0.6997 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.6997 | 0.7907 |
Brugia malayi | RNA binding protein | 0.0132 | 0.6997 | 0.7907 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.6997 | 0.7907 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.6997 | 0.7907 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.0401 | 0.0453 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.0401 | 0.0453 |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0401 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5121 | 0.5786 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0012 | 0.0061 | 0.0069 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0018 | 0.0401 | 0.0453 |
Entamoeba histolytica | cysteine protease, putative | 0.0018 | 0.0401 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0954 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.6997 | 0.6997 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.0401 | 0.0453 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5121 | 0.5786 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.0401 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5121 | 0.5786 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0401 | 0.0453 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0954 | 0.1916 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0082 | 0.0082 |
Onchocerca volvulus | 0.0018 | 0.0401 | 0.0453 | |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0401 | 0.0453 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0954 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0068 | 0.3288 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0012 | 0.0061 | 0.0069 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0068 | 0.3288 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Escherichia coli MG1655 harboring lepB P84L mutant after 24 hrs by CLSI broth microdilution method | ChEMBL. | 21630667 |
MIC (functional) | > 64 ug ml-1 | Antibacterial activity against Escherichia coli MG1655 after 24 hrs by CLSI broth microdilution method | ChEMBL. | 21630667 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.