Detailed information for compound 107776

Basic information

Technical information
  • TDR Targets ID: 107776
  • Name: 3-[(2,6-dichloro-4-hydroxyphenyl)methyl]-1H-i midazole-2-thione
  • MW: 275.154 | Formula: C10H8Cl2N2OS
  • H donors: 2 H acceptors: 1 LogP: 2.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(O)cc(c1Cn1cc[nH]c1=S)Cl
  • InChi: 1S/C10H8Cl2N2OS/c11-8-3-6(15)4-9(12)7(8)5-14-2-1-13-10(14)16/h1-4,15H,5H2,(H,13,16)
  • InChiKey: PDNOXCRMLLXBNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2,6-dichloro-4-hydroxy-phenyl)methyl]-1H-imidazole-2-thione
  • 1-(2,6-dichloro-4-hydroxy-benzyl)-4-imidazoline-2-thione
  • 1-[(2,6-dichloro-4-hydroxyphenyl)methyl]-3H-imidazole-2-thione
  • 1-[(2,6-dichloro-4-hydroxy-phenyl)methyl]-3H-imidazole-2-thione
  • 1-(2,6-dichloro-4-hydroxy-benzyl)-3H-imidazole-2-thione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii MAPEG family protein 0.0233 0.1528 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0014 0.0025 0.0161
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0025 0.0025
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0171 0.0265
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1471 1 1
Brugia malayi Carboxylesterase family protein 0.0091 0.0554 0.0554
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0047
Schistosoma mansoni rab6-interacting 0.002 0.0066 0.0066
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0554 0.0554
Toxoplasma gondii exonuclease III APE 0.0019 0.006 0.0391
Schistosoma mansoni hypothetical protein 0.0046 0.0247 0.0247
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) RecQ helicase 0.002 0.0067 0.0067
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0539 0.362 0.362
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Brugia malayi Carboxylesterase family protein 0.0091 0.0554 0.0554
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0554 0.2614
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Trichomonas vaginalis glycogen phosphorylase, putative 0.032 0.212 0.8248
Onchocerca volvulus Prolyl endopeptidase homolog 0.0131 0.0827 0.3902
Loa Loa (eye worm) hypothetical protein 0.0131 0.0827 0.0827
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.0827 0.0827
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Echinococcus multilocularis protein dispatched 1 0.0338 0.2242 0.2242
Onchocerca volvulus 0.0091 0.0554 0.2614
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0385 0.2565 1
Loa Loa (eye worm) carboxylesterase 0.0091 0.0554 0.0554
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0037 0.0186 0.0186
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0067 0.0437
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus multilocularis Ankyrin 0.0047 0.025 0.0249
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0046 0.0247 0.0247
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0047 0.1541
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.0138
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0047 0.0047
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.2404
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Schistosoma mansoni gliotactin 0.0091 0.0554 0.0554
Schistosoma mansoni acetylcholinesterase 0.0091 0.0554 0.0554
Brugia malayi hypothetical protein 0.0091 0.0554 0.0554
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.1018 0.6901 0.6901
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0138 0.0877 0.149
Onchocerca volvulus 0.0037 0.0186 0.0877
Trypanosoma cruzi oligopeptidase b 0.0052 0.0287 0.0475
Echinococcus multilocularis Glycosyl transferase, family 35 0.032 0.212 0.212
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0185 0.0629
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0186 0.0186
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.082 0.5546 0.5546
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Onchocerca volvulus 0.002 0.0066 0.0309
Schistosoma mansoni pcd6 interacting protein-related 0.0037 0.0186 0.0186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.0247 0.0247
Onchocerca volvulus 0.0037 0.0186 0.0877
Entamoeba histolytica glycogen phosphorylase, putative 0.0138 0.0877 0.4138
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0539 0.362 0.362
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.082 0.5546 1
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0047 0.0047
Echinococcus granulosus acetylcholinesterase 0.0539 0.362 0.362
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus granulosus netrin receptor unc 5 0.0046 0.0247 0.0247
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0067 0.0437
Schistosoma mansoni DNA helicase recq5 0.002 0.0067 0.0067
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0014 0.0025 0.0025
Echinococcus multilocularis acetylcholinesterase 0.0539 0.362 0.362
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0185 0.0185
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0186 0.0292
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0186 0.0292
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1471 1 1
Onchocerca volvulus 0.0037 0.0186 0.0877
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Brugia malayi Carboxylesterase family protein 0.0091 0.0554 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0171 0.0575
Echinococcus granulosus bloom syndrome protein 0.002 0.0067 0.0067
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0014 0.0025 0.0025
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0287 0.2782
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0017 0.0047 0.0222
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0554 0.0554
Onchocerca volvulus 0.0037 0.0186 0.0877
Schistosoma mansoni lipoxygenase 0.0082 0.0495 0.0495
Brugia malayi Kringle domain containing protein 0.0017 0.0047 0.0047
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Brugia malayi hypothetical protein 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0037 0.0186 0.0877
Brugia malayi Protein kinase domain containing protein 0.0017 0.0047 0.0047
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0066 0.0066
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.0025 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0066
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0037 0.0186 0.0186
Onchocerca volvulus 4.1 G protein, putative homolog 0.0037 0.0186 0.0877
Loa Loa (eye worm) hypothetical protein 0.0539 0.362 0.362
Echinococcus granulosus neuroligin 0.0091 0.0554 0.0554
Onchocerca volvulus 0.0091 0.0554 0.2614
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0538 0.3613 0.3613
Brugia malayi Carboxylesterase family protein 0.0091 0.0554 0.0554
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0025 0.0116
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.006 0.5
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0037 0.0186 0.0186
Trichomonas vaginalis glycogen phosphorylase, putative 0.032 0.212 0.8248
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0171 0.0265
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0067 0.0076
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0138 0.0877 1
Leishmania major oligopeptidase b 0.0052 0.0287 0.0475
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0047 0.0309
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.006 0.006
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0185 0.0629
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Echinococcus granulosus para nitrobenzyl esterase 0.0091 0.0554 0.0554
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0064
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0186 0.0186
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0385 0.2565 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0025 0.0025
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0047 0.0047
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0037 0.0186 0.0186
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0025 0.0025
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0025 0.0025
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0186 0.0877
Echinococcus multilocularis carboxylesterase 5A 0.0539 0.362 0.362
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Brugia malayi Doublecortin family protein 0.002 0.0066 0.0066
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0186 0.0186
Entamoeba histolytica glycogenphosphorylase, putative 0.0138 0.0877 0.4138
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.082 0.5546 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0067 0.0067
Entamoeba histolytica glycogen phosphorylase, putative 0.032 0.212 1
Onchocerca volvulus 0.0037 0.0186 0.0877
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0067 0.0166
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Schistosoma mansoni ankyrin 23/unc44 0.0046 0.0247 0.0247
Echinococcus multilocularis prolyl endopeptidase 0.0131 0.0827 0.0827
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0037 0.0186 0.0186
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0037 0.0186 0.0186
Echinococcus multilocularis Niemann Pick C1 protein 0.0338 0.2242 0.2242
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Onchocerca volvulus 0.0037 0.0186 0.0877
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0025 0.0025
Echinococcus multilocularis glycogen phosphorylase 0.032 0.212 0.212
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Echinococcus multilocularis transcription factor btf3 0.0035 0.0171 0.0171
Loa Loa (eye worm) acetylcholinesterase 1 0.0539 0.362 0.362
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0185 0.0185
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0037 0.0186 0.0292
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.0733 0.8238
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0067 0.288
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.006 0.006
Brugia malayi Protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0067 0.0067
Onchocerca volvulus 0.0037 0.0186 0.0877
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0014 0.0025 0.0116
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.082 0.5546 0.5546
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0287 0.0475
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0014 0.0025 0.0161
Echinococcus granulosus Ankyrin 0.0047 0.025 0.0249
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0171 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0171 0.0575
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) glycogen phosphorylase 0.032 0.212 0.212
Loa Loa (eye worm) hypothetical protein 0.0047 0.025 0.0249
Echinococcus multilocularis netrin receptor unc 5 0.0046 0.0247 0.0247
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Brugia malayi hypothetical protein 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0037 0.0186 0.0877
Echinococcus granulosus acetylcholinesterase 0.0539 0.362 0.362
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.006 0.0282
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.082 0.5546 0.5546
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0067 0.0067
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0.0025 0.0116
Schistosoma mansoni glycogen phosphorylase 0.032 0.212 0.212
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0.0025 0.0116
Onchocerca volvulus 0.0037 0.0186 0.0877
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0025 0.1445
Schistosoma mansoni rab6-interacting 0.002 0.0066 0.0066
Onchocerca volvulus Netrin receptor homolog 0.0046 0.0247 0.1164
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Mycobacterium ulcerans carboxylesterase, LipT 0.0091 0.0554 0.0901
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.0827 0.0827
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0185 0.029
Schistosoma mansoni BC026374 protein (S09 family) 0.0091 0.0554 0.0554
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0385 0.2565 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0037 0.0186 0.0186
Schistosoma mansoni loxhd1 0.002 0.0066 0.0066
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0287 0.0475
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Echinococcus granulosus Protein patched homolog 1 0.0338 0.2242 0.2242
Echinococcus granulosus transcription factor btf3 0.0035 0.0171 0.0171
Trypanosoma brucei protein tyrosine phosphatase 1 0.0037 0.0186 0.0292
Giardia lamblia Glycogen phosphorylase 0.032 0.212 0.8248
Echinococcus granulosus Dipeptidyl peptidase 9 0.0014 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0047 0.0041
Onchocerca volvulus 0.0037 0.0186 0.0877
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.0247
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0025 0.0116
Brugia malayi hypothetical protein 0.002 0.0066 0.0066
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0066 0.0066
Trypanosoma brucei oligopeptidase b 0.0052 0.0287 0.0475
Toxoplasma gondii prolyl endopeptidase 0.0131 0.0827 0.5413
Echinococcus multilocularis 0.0037 0.0186 0.0186
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.3501
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0066 0.0066
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0037 0.0186 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0025 0.000000033207
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Schistosoma mansoni glycogen phosphorylase 0.032 0.212 0.212
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0171 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0185 0.0185
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0091 0.0554 0.0554
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0066 0.2805
Echinococcus granulosus nuclear factor of activated T cells 5 0.0538 0.3613 0.3613
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0037 0.0186 0.0186
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1471 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0738 0.0738
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0185 0.0185
Onchocerca volvulus 0.002 0.0066 0.0309
Entamoeba histolytica recQ family helicase, putative 0.002 0.0067 0.0315
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0067 0.288
Onchocerca volvulus 0.0091 0.0554 0.2614
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0037 0.0186 0.0186
Brugia malayi beta-NAC-like protein 0.0035 0.0171 0.0171
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0338 0.2242 0.2242
Echinococcus granulosus Glycosyl transferase family 35 0.032 0.212 0.212
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0037 0.0186 0.0186
Trypanosoma cruzi prolyl endopeptidase 0.0131 0.0827 0.1453
Brugia malayi Death domain containing protein 0.0046 0.0247 0.0247
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0186 0.0186
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0037 0.0186 0.0186
Echinococcus granulosus microsomal glutathione S transferase 3 0.0233 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Entamoeba histolytica glycogen phosphorylase, putative 0.032 0.212 1
Schistosoma mansoni polycystin 1-related 0.002 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0171 0.0575
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.082 0.5546 0.5546
Onchocerca volvulus 0.0037 0.0186 0.0877
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0037 0.0186 0.0186
Loa Loa (eye worm) doublecortin family protein 0.002 0.0066 0.0066
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0338 0.2242 0.2242
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0047 0.2763
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0287 0.0475
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0185 0.0185
Chlamydia trachomatis glycogen phosphorylase 0.032 0.212 0.5
Leishmania major tyrosine specific protein phosphatase, putative 0.0037 0.0186 0.0292
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0185 0.0185
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.006
Brugia malayi Carboxylesterase family protein 0.0539 0.362 0.362
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1269 0.8618 0.8618
Brugia malayi Uncoordinated protein 44 0.0046 0.0247 0.0247
Onchocerca volvulus 0.0037 0.0186 0.0877
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.082 0.5546 1
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2242 0.873
Onchocerca volvulus 0.0037 0.0186 0.0877
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0385 0.2565 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0037 0.0186 0.0877
Onchocerca volvulus 0.0037 0.0186 0.0877
Toxoplasma gondii hypothetical protein 0.0014 0.0025 0.0161
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Echinococcus granulosus protein tyrosine phosphatase n9 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0067 0.0067
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.0827 0.0827
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Echinococcus granulosus glycogen phosphorylase 0.032 0.212 0.212
Brugia malayi Protein kinase domain containing protein 0.0047 0.0251 0.0251
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Brugia malayi hypothetical protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0091 0.0554 0.2084
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0185 0.0871
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0037 0.0186 0.0877
Echinococcus multilocularis acetylcholinesterase 0.0539 0.362 0.362
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0171 0.0805
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0185 0.0185
Schistosoma mansoni patched 1 0.0338 0.2242 0.2242
Echinococcus granulosus BC026374 protein S09 family 0.0091 0.0554 0.0554
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0185 0.0185
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0037 0.0186 0.0877
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0066 0.3845
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0091 0.0554 0.0554
Brugia malayi hypothetical protein 0.002 0.0066 0.0066
Echinococcus multilocularis sterol regulatory element binding protein 0.0338 0.2242 0.2242
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0091 0.0554 0.0554
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0014 0.0025 0.0025
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0037 0.0186 0.0292
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0046 0.0247 0.0247
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0037 0.0186 0.0186
Echinococcus granulosus Niemann Pick C1 protein 0.0338 0.2242 0.2242
Onchocerca volvulus 0.0037 0.0186 0.0877
Onchocerca volvulus Glycogen phosphorylase homolog 0.032 0.212 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0287 0.2782
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Echinococcus multilocularis bloom syndrome protein 0.002 0.0067 0.0067
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0287 0.0475
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.006 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0025 0.000000033207
Onchocerca volvulus 0.0037 0.0186 0.0877
Echinococcus multilocularis neuroligin 0.0091 0.0554 0.0554
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0047 0.025 0.0249
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0186 0.0186
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0067 0.0067
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase 1 0.0037 0.0186 0.0186
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0014 0.0025 0.0025
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0091 0.0554 0.6048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Brugia malayi hypothetical protein 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Entamoeba histolytica glycogen phosphorylase, putative 0.0138 0.0877 0.4138
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0185 0.029
Schistosoma mansoni lipoxygenase 0.0118 0.0738 0.0738
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0067 0.0067
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0025 0.0025
Echinococcus multilocularis protein patched 0.0338 0.2242 0.2242
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0231 0.151 0.151
Brugia malayi hypothetical protein 0.0037 0.0186 0.0186
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.082 0.5546 0.5546
Loa Loa (eye worm) protein tyrosine phosphatase 0.0037 0.0186 0.0186
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0287 0.5
Schistosoma mansoni DNA helicase recq1 0.002 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0017 0.0047 0.0047
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0014 0.0025 0.0025
Brugia malayi Carboxylesterase family protein 0.0539 0.362 0.362
Loa Loa (eye worm) carboxylesterase 0.0091 0.0554 0.0554
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0554 0.0554
Onchocerca volvulus 0.0037 0.0186 0.0877
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0186 0.0186
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0186 0.0186
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0037 0.0186 0.0186
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0067 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0247 0.0247
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0067 0.0166
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0067 0.0166
Echinococcus granulosus carboxylesterase 5A 0.0539 0.362 0.362
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0185 0.029
Echinococcus multilocularis RUN 0.002 0.0066 0.0066
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0037 0.0186 0.0186
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0131 0.0827 0.1453
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0037 0.0186 0.0186
Entamoeba histolytica hypothetical protein 0.0035 0.0171 0.0805
Loa Loa (eye worm) carboxylesterase 0.0539 0.362 0.362
Echinococcus granulosus sterol regulatory element binding protein 0.0338 0.2242 0.2242
Echinococcus granulosus RUN 0.002 0.0066 0.0066
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0067 0.0067
Schistosoma mansoni microsomal glutathione s-transferase 0.0233 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0185 0.0629
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0287 0.0475
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0025 0.0116
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0738 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0185 0.0629
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0025 0.0025
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1471 1 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0185 0.0185
Echinococcus granulosus glycogen phosphorylase 0.032 0.212 0.212
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0067 0.0166
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.006 0.5
Schistosoma mansoni transcription factor btf3 0.0035 0.0171 0.0171
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Leishmania major basic transcription factor 3a, putative 0.0035 0.0171 0.0265
Schistosoma mansoni hypothetical protein 0.002 0.0066 0.0066
Echinococcus multilocularis glycogen phosphorylase 0.032 0.212 0.212
Brugia malayi carbohydrate phosphorylase 0.032 0.212 0.212
Giardia lamblia Protein tyrosine phosphatase 0.0037 0.0186 0.0635
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0064
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0025 0.0025
Echinococcus multilocularis BC026374 protein (S09 family) 0.0091 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0066
Trypanosoma brucei prolyl endopeptidase 0.0131 0.0827 0.1453
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0037 0.0186 0.0186
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.006 0.006
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0037 0.0186 0.0186
Echinococcus granulosus prolyl endopeptidase 0.0131 0.0827 0.0827
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0171 0.1117
Trichomonas vaginalis spcc417.12 protein, putative 0.0091 0.0554 0.2084
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.006 0.0064
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.0287 0.0414
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0037 0.0186 0.0877
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0091 0.0554 0.6048
Echinococcus multilocularis hypothetical protein 0.0037 0.0186 0.0186
Mycobacterium tuberculosis Carboxylesterase LipT 0.0091 0.0554 0.6048
Trichomonas vaginalis pten, drome, putative 0.0037 0.0186 0.0635
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0066 0.0066
Onchocerca volvulus 0.0091 0.0554 0.2614
Trypanosoma cruzi oligopeptidase b 0.0052 0.0287 0.0475
Onchocerca volvulus 0.0037 0.0186 0.0877
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0037 0.0186 0.0877
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0037 0.0186 0.0186
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0067 0.0076
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.006 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0037 0.0186 0.0877
Schistosoma mansoni protein tyrosine phosphatase 0.0037 0.0186 0.0186
Leishmania major hypothetical protein, conserved 0.0017 0.0047 0.0041
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Echinococcus multilocularis para nitrobenzyl esterase 0.0091 0.0554 0.0554
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0185 0.029
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.082 0.5546 1
Echinococcus granulosus death domain containing protein 0.0046 0.0247 0.0247
Schistosoma mansoni netrin receptor unc5 0.0046 0.0247 0.0247
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.082 0.5546 1
Loa Loa (eye worm) hypothetical protein 0.0338 0.2242 0.2242
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0185 0.0185
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0186 0.0186
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0067 0.0067
Schistosoma mansoni neuroligin 3 (S09 family) 0.0091 0.0554 0.0554
Schistosoma mansoni glycogen phosphorylase 0.0138 0.0877 0.0877
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0037 0.0186 0.0186
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0233 0.1528 0.1528
Brugia malayi CHE-14 protein 0.0338 0.2242 0.2242
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0171 0.0171
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0171 0.0265

Activities

Activity type Activity value Assay description Source Reference
-Log IC50 (binding) = 4.12 Inhibition of dopamine beta hydroxylase ChEMBL. 7783140
-Log IC50 (binding) = 4.12 Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally ChEMBL. 2296023
IC50 (binding) = 4.12 Inhibition of dopamine beta hydroxylase ChEMBL. 7783140
IC50 (binding) = 4.12 Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally ChEMBL. 2296023
IC50 (binding) = 4.12 Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme ChEMBL. 9435905
IC50 (binding) = 75 uM Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (36-102) ChEMBL. 3820219
IC50 (binding) = 75 uM Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (36-102) ChEMBL. 3820219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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