Detailed information for compound 1077905

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.442 | Formula: C22H24FN3O4
  • H donors: 1 H acceptors: 2 LogP: 3.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1O[C@@H]([C@H](N1)CN1CCN(CC1)c1ccccc1)COC(=O)c1ccccc1F
  • InChi: 1S/C22H24FN3O4/c23-18-9-5-4-8-17(18)21(27)29-15-20-19(24-22(28)30-20)14-25-10-12-26(13-11-25)16-6-2-1-3-7-16/h1-9,19-20H,10-15H2,(H,24,28)/t19-,20-/m1/s1
  • InChiKey: LGWWLUYBKBHXDE-WOJBJXKFSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0082 0.0065
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0549 0.0549
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0018 0.0018
Trichomonas vaginalis tubulin alpha chain, putative 0.0584 0.5546 0.5538
Trypanosoma brucei beta tubulin 0.0584 0.5546 0.5546
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0793 0.0793
Brugia malayi SET domain containing protein 0.0012 0.0024 0.0024
Echinococcus granulosus Chromo domain 0.0011 0.0018 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0452 0.0452
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0304 0.0287
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0018 0.0018
Echinococcus granulosus tubulin alpha chain 0.0779 0.7428 0.7428
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0082 0.0065
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0549 0.0549
Trichomonas vaginalis tubulin, putative 0.0316 0.2964 0.2952
Echinococcus multilocularis tubulin alpha chain 0.0779 0.7428 0.7428
Schistosoma mansoni transient receptor potential channel 0.0206 0.19 0.19
Brugia malayi Tubulin beta chain 0.0267 0.2492 0.2492
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0048 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0793 0.0793
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0276 0.0931
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0018 0.0018
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1395 0.1395
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.008 0.008
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0009
Schistosoma mansoni tubulin subunit beta 0.0267 0.2492 0.2492
Giardia lamblia Gamma tubulin 0.0637 0.606 0.5679
Loa Loa (eye worm) alpha-tubulin 0.0779 0.7428 0.7428
Echinococcus multilocularis Tubulin alpha 1 chain 0.0779 0.7428 0.7428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Trypanosoma cruzi tubulin gamma chain 0.0637 0.606 0.606
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0549 0.0549
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0549 0.0533
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0047 0.0047
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Mycobacterium leprae cell division protein FtsZ 0.0267 0.2492 0.5
Trypanosoma cruzi epsilon tubulin, putative 0.0636 0.6053 0.6053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Trypanosoma brucei alpha tubulin 0.0779 0.7428 0.7428
Echinococcus granulosus tubulin alpha 3 chain 0.0779 0.7428 0.7428
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Echinococcus granulosus alpha tubulin 0.0779 0.7428 0.7428
Trichomonas vaginalis tubulin alpha chain, putative 0.0316 0.2964 0.2952
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0169 0.0152
Loa Loa (eye worm) alpha-tubulin 0.0779 0.7428 0.7428
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0101 0.0881 0.0881
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0463 0.4375 0.4375
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0597 0.567 0.567
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0047 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0793 0.0793
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Trypanosoma brucei alpha tubulin 0.0779 0.7428 0.7428
Plasmodium falciparum tubulin delta chain, putative 0.0267 0.2492 0.2479
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0009
Trypanosoma brucei tubulin gamma chain 0.0637 0.606 0.606
Trypanosoma brucei zeta tubulin 0.0818 0.7805 0.7805
Echinococcus multilocularis tubulin alpha chain 0.0779 0.7428 0.7428
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0009 0.0029
Brugia malayi Heterochromatin protein 1 0.0067 0.0562 0.0562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.008 0.008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0511 0.4847 0.4838
Brugia malayi Cytochrome P450 family protein 0.0024 0.0145 0.0145
Echinococcus multilocularis Chromo domain 0.0011 0.0018 0.0018
Echinococcus multilocularis mitogen activated protein kinase 3 0.0101 0.0881 0.0881
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0101 0.0881 0.0881
Loa Loa (eye worm) tubulin gamma chain 0.0637 0.606 0.606
Schistosoma mansoni cpg binding protein 0.003 0.0196 0.0196
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Echinococcus multilocularis peroxisome assembly protein 26 0.0779 0.7428 0.7428
Echinococcus multilocularis cpg binding protein 0.0031 0.0213 0.0213
Trypanosoma brucei alpha tubulin 0.0779 0.7428 0.7428
Brugia malayi alpha-tubulin 0.0779 0.7428 0.7428
Brugia malayi MAP kinase sur-1 0.0101 0.0881 0.0881
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0281 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0009
Onchocerca volvulus 0.003 0.0197 0.0665
Brugia malayi steroid hormone receptor 0.001 0.0009 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0793 0.0793
Echinococcus granulosus tubulin subunit TubB 0.0779 0.7428 0.7428
Brugia malayi CHD4 protein 0.0013 0.0034 0.0034
Echinococcus multilocularis chromobox protein 1 0.0067 0.0562 0.0562
Echinococcus multilocularis short transient receptor potential channel 6 0.0137 0.1234 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0009 0.0009
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0009
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0101 0.0881 0.0881
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0018 0.0018
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0333 0.0333
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0562 0.0562
Echinococcus multilocularis hypothetical protein 0.0779 0.7428 0.7428
Brugia malayi tubulin alpha-2 chain 0.0779 0.7428 0.7428
Loa Loa (eye worm) helicase 0.0011 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0009 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0881 0.0865
Plasmodium vivax tubulin epsilon chain, putative 0.0636 0.6053 0.6046
Loa Loa (eye worm) tubulin alpha-3 chain 0.0463 0.4375 0.4375
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0197 0.0197
Echinococcus multilocularis chromobox protein 1 0.0067 0.0562 0.0562
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0047 0.0047
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0034 0.0034
Echinococcus multilocularis tubulin alpha chain 0.0779 0.7428 0.7428
Trichomonas vaginalis tubulin gamma chain, putative 0.0267 0.2492 0.2479
Brugia malayi tubulin alpha chain - mouse 0.0779 0.7428 0.7428
Schistosoma mansoni chromobox protein 0.0011 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0881 0.0865
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0082 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0009
Leishmania major zeta tubulin, putative 0.0818 0.7805 0.7805
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0009
Echinococcus granulosus tubulin delta chain 0.0267 0.2492 0.2492
Brugia malayi nuclear hormone receptor 0.001 0.0009 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Trichomonas vaginalis tubulin alpha chain, putative 0.0316 0.2964 0.2952
Echinococcus granulosus dnaJ subfamily B 0.0421 0.3976 0.3976
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0018 0.0018
Echinococcus granulosus tubulin alpha 0.0584 0.5546 0.5546
Toxoplasma gondii alpha-tubulin I, putative 0.0779 0.7428 0.7428
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0009
Onchocerca volvulus 0.001 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0154 0.1395 0.1395
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0047 0.0047
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0009 0.0009
Echinococcus granulosus short transient receptor potential channel 6 0.0137 0.1234 0.1234
Giardia lamblia Alpha-tubulin 0.0779 0.7428 0.718
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.032 0.2999 0.2999
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0881 0.0881
Loa Loa (eye worm) tubulin alpha-2 chain 0.0779 0.7428 0.7428
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0052 0.0035
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0333 0.0333
Echinococcus granulosus tubulin gamma 1 chain 0.0637 0.606 0.606
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0511 0.4847 0.4847
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0082 0.0065
Schistosoma mansoni nuclear hormone receptor 0.001 0.0009 0.0009
Trypanosoma brucei protein kinase, putative 0.0101 0.0881 0.0881
Trypanosoma cruzi zeta tubulin, putative 0.0818 0.7805 0.7805
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0034 0.0034
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0145 0.0145
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0009 0.0009
Echinococcus granulosus chromobox protein 1 0.0067 0.0562 0.0562
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0047 0.0047
Plasmodium vivax tubulin gamma chain, putative 0.0637 0.606 0.6053
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0316 0.2964 0.2952
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0562 0.0546
Schistosoma mansoni tubulin subunit epsilon 0.0636 0.6053 0.6053
Giardia lamblia Epsilon tubulin 0.032 0.2999 0.2323
Trichomonas vaginalis tubulin beta chain, putative 0.0779 0.7428 0.7424
Trichomonas vaginalis tubulin beta chain, putative 0.0779 0.7428 0.7424
Brugia malayi Tubulin alpha-2 chain 0.0779 0.7428 0.7428
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0034 0.0034
Schistosoma mansoni chromobox protein 0.0067 0.0562 0.0562
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0881 0.0865
Echinococcus granulosus tubulin alpha chain 0.0779 0.7428 0.7428
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Leishmania major gamma-tubulin 0.0637 0.606 0.606
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0286
Echinococcus granulosus mitogen activated protein kinase 3 0.0101 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Brugia malayi Cell division protein ftsZ 0.0267 0.2492 0.2492
Trypanosoma cruzi tubulin delta chain 0.0597 0.567 0.567
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0018 0.0018
Schistosoma mansoni transient receptor potential channel 0.0137 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0047 0.003
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0009 0.0009
Echinococcus granulosus transient receptor potential ion channel A 0.0197 0.1811 0.1811
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0009 0.0009
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0034 0.0034
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0047 0.0047
Onchocerca volvulus 0.0011 0.0018 0.0059
Plasmodium vivax tubulin alpha chain, putative 0.0779 0.7428 0.7424
Schistosoma mansoni coup transcription factor 0.001 0.0009 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Brugia malayi chromobox protein homolog 3 0.0038 0.0276 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0009
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0196 0.0196
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0793 0.0793
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0304 0.1025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0881 0.0881
Brugia malayi Protein cec-1. 0.0011 0.0018 0.0018
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0145 0.0145
Echinococcus multilocularis Tubulin alpha 1 chain 0.0779 0.7428 0.7428
Leishmania major delta tubulin, putative 0.0597 0.567 0.567
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.008 0.008
Schistosoma mansoni tubulin subunit alpha 0.0779 0.7428 0.7428
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0082 0.0065
Trichomonas vaginalis tubulin alpha chain, putative 0.0316 0.2964 0.2952
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0078 0.0665 0.0665
Schistosoma mansoni chromobox protein 0.0067 0.0562 0.0562
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0145 0.0145
Echinococcus multilocularis tubulin alpha 1C chain 0.0779 0.7428 0.7428
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0052 0.0035
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0304 0.0287
Trypanosoma brucei epsilon tubulin 0.0636 0.6053 0.6053
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0549 0.0549
Echinococcus multilocularis tubulin alpha 0.0584 0.5546 0.5546
Echinococcus multilocularis calcium activated potassium channel 0.001 0.0009 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0009 0.0009
Onchocerca volvulus 0.0012 0.0024 0.008
Echinococcus multilocularis tubulin gamma 1 chain 0.0637 0.606 0.606
Entamoeba histolytica tubulin gamma chain 0.0637 0.606 0.6053
Schistosoma mansoni alpha tubulin 0.0779 0.7428 0.7428
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0047 0.0047
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0047 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0009
Echinococcus granulosus Tubulin alpha 1 chain 0.0779 0.7428 0.7428
Echinococcus granulosus cpg binding protein 0.0031 0.0213 0.0213
Echinococcus multilocularis muscleblind protein 0.0154 0.1395 0.1395
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0082 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0082 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0082 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0009
Trypanosoma cruzi tubulin delta chain 0.0597 0.567 0.567
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Loa Loa (eye worm) tubulin alpha 2 0.0511 0.4847 0.4847
Loa Loa (eye worm) hypothetical protein 0.0017 0.008 0.008
Brugia malayi Tubulin gamma chain 0.0637 0.606 0.606
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0031 0.0213 0.0213
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0549 0.0549
Echinococcus granulosus tubulin epsilon chain 0.0636 0.6053 0.6053
Toxoplasma gondii tubulin, putative 0.0053 0.0418 0.0418
Echinococcus granulosus chromobox protein 2 0.0011 0.0018 0.0018
Loa Loa (eye worm) tubulin alpha chain 0.0779 0.7428 0.7428
Echinococcus granulosus tubulin alpha 1C chain 0.0779 0.7428 0.7428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0047 0.0047
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0145 0.0145
Echinococcus granulosus Tubulin alpha 1 chain 0.0779 0.7428 0.7428
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Echinococcus multilocularis mitogen activated protein kinase 0.0101 0.0881 0.0881
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0009
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0281 0.0281
Brugia malayi Tubulin alpha chain 0.0779 0.7428 0.7428
Trypanosoma brucei alpha tubulin 0.0779 0.7428 0.7428
Schistosoma mansoni alpha tubulin 0.0779 0.7428 0.7428
Echinococcus multilocularis tubulin alpha 3 chain 0.0779 0.7428 0.7428
Echinococcus multilocularis Tubulin alpha 1 chain 0.0779 0.7428 0.7428
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0009
Schistosoma mansoni alpha tubulin 0.0779 0.7428 0.7428
Echinococcus multilocularis tubulin subunit TubB 0.0779 0.7428 0.7428
Trichomonas vaginalis tubulin epsilon chain, putative 0.0779 0.7428 0.7424
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0047 0.0047
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0018 0.0018
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0009 0.0009
Echinococcus granulosus tubulin alpha chain 0.0779 0.7428 0.7428
Mycobacterium ulcerans cell division protein FtsZ 0.0267 0.2492 1
Echinococcus granulosus Chromobox protein 3 0.0011 0.0018 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0009
Brugia malayi Tubulin alpha chain 0.0267 0.2492 0.2492
Trichomonas vaginalis tubulin epsilon chain, putative 0.0779 0.7428 0.7424
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0549 0.0549
Schistosoma mansoni tubulin subunit delta 0.0267 0.2492 0.2492
Plasmodium falciparum alpha tubulin 2 0.0779 0.7428 0.7424
Onchocerca volvulus 0.0316 0.2964 1
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0033 0.0033
Brugia malayi ecdysteroid receptor 0.001 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0009
Leishmania major epsilon tubulin, putative 0.0636 0.6053 0.6053
Echinococcus multilocularis transient receptor potential gamma protein 0.0206 0.19 0.19
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Echinococcus granulosus tubulin alpha chain 0.0779 0.7428 0.7428
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0366 0.0366
Trichomonas vaginalis tubulin, putative 0.0316 0.2964 0.2952
Giardia lamblia Alpha-tubulin 0.0779 0.7428 0.718
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0779 0.7428 0.7424
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0244 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0793 0.0793
Echinococcus granulosus mitogen activated protein kinase 0.0101 0.0881 0.0881
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0009 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0366 0.0366
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.2151 0.2151
Brugia malayi follicle stimulating hormone receptor 0.0232 0.2151 0.2151
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0549 0.0549
Brugia malayi Tubulin beta chain 0.0316 0.2964 0.2964
Schistosoma mansoni cpg binding protein 0.0031 0.0213 0.0213
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0101 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0047
Schistosoma mansoni tubulin subunit alpha 0.0779 0.7428 0.7428
Echinococcus multilocularis tubulin delta chain 0.0267 0.2492 0.2492
Trichomonas vaginalis conserved hypothetical protein 0.0267 0.2492 0.2479
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0101 0.0881 0.0881
Echinococcus multilocularis tubulin alpha chain 0.0779 0.7428 0.7428
Echinococcus granulosus transient receptor potential gamma protein 0.0206 0.19 0.19
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0009
Loa Loa (eye worm) tubulin alpha 2 0.0195 0.1794 0.1794
Loa Loa (eye worm) tubulin alpha 2 0.0511 0.4847 0.4847
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0463 0.4375 0.4365
Schistosoma mansoni 60S ribosomal protein L21 0.0013 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Brugia malayi hypothetical protein 0.0011 0.0018 0.0018
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0009 0.0009
Onchocerca volvulus 0.003 0.0196 0.0663
Trichomonas vaginalis tubulin beta chain, putative 0.0779 0.7428 0.7424
Trichomonas vaginalis tubulin beta chain, putative 0.0779 0.7428 0.7424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0793 0.0793
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0009 0.0029
Trypanosoma cruzi zeta tubulin, putative 0.0818 0.7805 0.7805
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0009
Brugia malayi Transient-receptor-potential like protein 0.0078 0.0665 0.0665
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0009
Plasmodium vivax delta tubulin, putative 0.0267 0.2492 0.2479
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0145 0.0145
Plasmodium falciparum tubulin gamma chain 0.0637 0.606 0.6053
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0018 0.0018
Echinococcus granulosus tubulin alpha 3 chain 0.0779 0.7428 0.7428
Trypanosoma brucei epsilon tubulin 0.0636 0.6053 0.6053
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0169 0.0152
Loa Loa (eye worm) hypothetical protein 0.0078 0.0665 0.0665
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0516 0.0516
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0793 0.0793
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0047 0.0047
Trypanosoma brucei zeta tubulin, putative 0.0818 0.7805 0.7805
Loa Loa (eye worm) hypothetical protein 0.0154 0.1395 0.1395
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.008 0.008
Schistosoma mansoni transient receptor potential channel 4 0.0206 0.19 0.19
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Entamoeba histolytica tubulin alpha-1 chain 0.0779 0.7428 0.7424
Trichomonas vaginalis tubulin beta chain, putative 0.0779 0.7428 0.7424
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0047 0.0047
Plasmodium falciparum alpha tubulin 1 0.0779 0.7428 0.7424
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0101 0.0881 0.0881
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.0009
Schistosoma mansoni tubulin subunit alpha 0.0779 0.7428 0.7428
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0009 0.0009
Echinococcus granulosus chromobox protein 1 0.0067 0.0562 0.0562
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0267 0.2492 0.5
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0078 0.0078
Echinococcus granulosus voltage gated potassium channel 0.0017 0.008 0.008
Treponema pallidum cell division protein FtsZ 0.0267 0.2492 0.5
Brugia malayi nuclear receptor NHR-88 0.001 0.0009 0.0009
Echinococcus multilocularis tubulin alpha 3 chain 0.0779 0.7428 0.7428
Trypanosoma cruzi epsilon tubulin, putative 0.0636 0.6053 0.6053
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0047 0.0047
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.008 0.008
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0562 0.0546
Schistosoma mansoni hypothetical protein 0.0421 0.3976 0.3976
Schistosoma mansoni transient receptor potential channel 0.0137 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.0038 0.0276 0.0276
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0881 0.0881
Onchocerca volvulus 0.0011 0.0018 0.0059
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0549 0.0549
Echinococcus multilocularis tubulin epsilon chain 0.0636 0.6053 0.6053
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0018 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0009
Mycobacterium tuberculosis Cell division protein FtsZ 0.0267 0.2492 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0779 0.7428 0.7424
Leishmania major cytochrome p450-like protein 0.0024 0.0145 0.0145
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0267 0.2492 0.2479
Echinococcus granulosus muscleblind protein 0.0154 0.1395 0.1395
Echinococcus granulosus tubulin alpha 1C chain 0.0779 0.7428 0.7428
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0009
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0018 0.0018
Schistosoma mansoni tubulin subunit gamma 0.0637 0.606 0.606
Echinococcus granulosus peroxisome assembly protein 26 0.0779 0.7428 0.7428
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.008 0.008
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0584 0.5546 0.5546
Echinococcus multilocularis tubulin alpha chain 0.0779 0.7428 0.7428
Echinococcus multilocularis tubulin alpha 1C chain 0.0779 0.7428 0.7428
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0047 0.0047
Brugia malayi CXXC zinc finger family protein 0.003 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0511 0.4847 0.4847
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0018 0.0018
Loa Loa (eye worm) tubulin beta chain 0.0267 0.2492 0.2492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0047 0.003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0333 0.0333
Entamoeba histolytica tubulin alpha chain, putative 0.0779 0.7428 0.7424
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0333 0.0333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0244 0.0227
Brugia malayi Muscleblind-like protein 0.0154 0.1395 0.1395
Plasmodium vivax tubulin alpha chain, putative 0.0779 0.7428 0.7424
Trichomonas vaginalis tubulin beta chain, putative 0.0316 0.2964 0.2952
Echinococcus granulosus calcium activated potassium channel 0.001 0.0009 0.0009
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0018 0.0018
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0047 0.0047
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0267 0.2492 0.2479
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0145 0.0145
Trypanosoma brucei alpha tubulin, putative 0.0316 0.2964 0.2964
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0018
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0549 0.0549
Trypanosoma brucei epsilon tubulin 0.0584 0.5546 0.5546
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0276 0.0259
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Echinococcus granulosus short transient receptor potential channel 6 0.0137 0.1234 0.1234
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0881 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Schistosoma mansoni chromobox protein 0.0011 0.0018 0.0018
Echinococcus multilocularis short transient receptor potential channel 6 0.0137 0.1234 0.1234
Trichomonas vaginalis tubulin, putative 0.0321 0.3007 0.2994
Trypanosoma brucei tubulin delta chain 0.0597 0.567 0.567
Echinococcus granulosus TRP transient receptor potential channel 0.0078 0.0665 0.0665
Trypanosoma cruzi alpha tubulin, putative 0.0779 0.7428 0.7428
Echinococcus granulosus tubulin alpha chain 0.0779 0.7428 0.7428
Loa Loa (eye worm) hypothetical protein 0.0069 0.0576 0.0576
Schistosoma mansoni tubulin subunit alpha 0.0267 0.2492 0.2492
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0101 0.0881 0.0881
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.3976 0.3976
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0047 0.0047
Echinococcus granulosus Tubulin alpha 1 chain 0.0779 0.7428 0.7428
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0276 0.0259
Plasmodium falciparum tubulin epsilon chain, putative 0.0636 0.6053 0.6046
Toxoplasma gondii alpha tubulin TUBA1 0.0779 0.7428 0.7428
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0047 0.0047
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0206 0.19 0.19
Giardia lamblia Delta tubulin 0.0267 0.2492 0.1767
Brugia malayi Cytochrome P450 family protein 0.0024 0.0145 0.0145
Trichomonas vaginalis tubulin gamma chain, putative 0.0636 0.6053 0.6046
Leishmania major alpha tubulin 0.0779 0.7428 0.7428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Echinococcus multilocularis chromobox protein 2 0.0011 0.0018 0.0018
Echinococcus multilocularis transient receptor potential ion channel A 0.0197 0.1811 0.1811
Loa Loa (eye worm) tubulin alpha chain 0.0779 0.7428 0.7428
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Trichomonas vaginalis tubulin epsilon chain, putative 0.0267 0.2492 0.2479
Trichomonas vaginalis tubulin gamma chain, putative 0.0637 0.606 0.6053
Loa Loa (eye worm) hypothetical protein 0.0128 0.1145 0.1145
Brugia malayi Tubulin alpha-2 chain 0.0779 0.7428 0.7428
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0779 0.7428 0.7428

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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