TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 189.017 | Formula: C7H16BNO4
H donors: 3 H acceptors: 4 LogP: -2.16 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OB(CCCCC(C(=O)[O-])([NH3+])C)O
InChi: 1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
InChiKey: VJCNFQNUKLFMMR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arginase 1	Starlite/ChEMBL	References
Homo sapiens	arginase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium vivax	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania mexicana	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma japonicum	ko:K01476 arginase [EC3.5.3.1], putative	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania major	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania braziliensis	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma mansoni	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania infantum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium berghei	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium falciparum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania donovani	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis	arginase 2, mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis		Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium knowlesi	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0041	0.0375	0.1624
Brugia malayi	hypothetical protein	0.0018	0.0059	0.0106
Echinococcus granulosus	lysosomal alpha glucosidase	0.0171	0.2173	0.2395
Loa Loa (eye worm)	hypothetical protein	0.0266	0.3494	0.6282
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0262	0.0473
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0099	0.1179	0.13
Echinococcus multilocularis	muscleblind protein	0.0266	0.3494	0.3494
Schistosoma mansoni	calpain (C02 family)	0.0017	0.0047	0.0052
Schistosoma mansoni	hypothetical protein	0.003	0.0216	0.0238
Echinococcus granulosus	lamin	0.0026	0.0171	0.0189
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0017	0.0047	0.0248
Mycobacterium tuberculosis	Probable reductase	0.0092	0.1086	0.1265
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0014	0.0001	0.0008
Toxoplasma gondii	ABC1 family protein	0.0099	0.1179	1
Leishmania major	agmatinase-like protein	0.0151	0.189	0.3415
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0092	0.1086	0.1265
Echinococcus multilocularis	calpain family protein 1, d	0.0041	0.0375	0.0375
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0103	0.1229	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0061	0.0657	0.0724
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0017	0.0047	0.0052
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0367	0.0663
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.2173	0.2173
Echinococcus granulosus	survival motor neuron protein 1	0.0416	0.5563	0.6132
Schistosoma mansoni	hypothetical protein	0.0068	0.0747	0.0824
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0367	0.066
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0331	0.0598
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0171	0.0189
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0367	0.0663
Echinococcus multilocularis	muscleblind protein 1	0.0266	0.3494	0.3494
Leishmania major	arginase	0.0414	0.5535	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0331	0.0598
Echinococcus granulosus	calpain	0.0017	0.0047	0.0052
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	0.0414	0.5535	0.6101
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0425	0.0764
Brugia malayi	Thioredoxin reductase	0.0041	0.0367	0.066
Mycobacterium ulcerans	hypothetical protein	0.0099	0.1179	1
Trypanosoma brucei	agmatinase, putative	0.0151	0.189	1
Brugia malayi	calpain 7	0.0017	0.0047	0.0084
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0108	0.13	0.13
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0001	0.0003
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0017	0.0047	0.0248
Mycobacterium tuberculosis	Probable hydrolase	0.0099	0.1179	0.1374
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0331	0.2807
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0044	0.0414	0.0414
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0018	0.0059	0.0059
Echinococcus multilocularis	calpain A	0.0061	0.0657	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0165	0.0296
Trichomonas vaginalis	D-aminoacylase, putative	0.0099	0.1179	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0266	0.3494	0.6282
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0262	0.0262
Trypanosoma brucei	glucosidase, putative	0.0038	0.0331	0.1751
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0014	0.0001	0.0003
Schistosoma mansoni	hypothetical protein	0.002	0.0084	0.0092
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0258	0.3378	0.6072
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0734	0.1319
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0367	0.0663
Brugia malayi	hypothetical protein	0.0416	0.5563	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0099	0.1179	0.1374
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0058	0.0616	0.0679
Plasmodium vivax	arginase, putative	0.0414	0.5535	1
Brugia malayi	MH2 domain containing protein	0.0116	0.1409	0.2533
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0258	0.3378	0.6072
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0099	0.1179	0.212
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0017	0.0047	0.0248
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0331	0.0598
Echinococcus granulosus	geminin	0.0307	0.4064	0.448
Brugia malayi	Doublecortin family protein	0.0018	0.0059	0.0106
Trypanosoma brucei	calpain-like protein, putative	0.0017	0.0047	0.0248
Echinococcus granulosus	peregrin	0.0033	0.0262	0.0289
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0017	0.0047	0.0085
Echinococcus multilocularis	hypothetical protein	0.0017	0.0047	0.0047
Schistosoma mansoni	calpain-7 (C02 family)	0.0017	0.0047	0.0052
Schistosoma mansoni	lipoxygenase	0.0018	0.0059	0.0065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0258	0.3378	0.3723
Trypanosoma brucei	calpain-like protein, putative	0.0017	0.0047	0.0248
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0099	0.1179	0.212
Trichomonas vaginalis	Arginase, putative	0.0414	0.5535	1
Schistosoma mansoni	transcription factor LCR-F1	0.0068	0.0747	0.0824
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.0367	0.0367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0248
Loa Loa (eye worm)	beta-lactamase	0.0099	0.1179	0.212
Giardia lamblia	PHD finger protein 15	0.0033	0.0262	1
Onchocerca volvulus		0.0099	0.1175	0.5104
Brugia malayi	calpain family protein 1	0.0058	0.0616	0.1107
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0103	0.1229	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0416	0.5563	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0216	0.0389
Schistosoma mansoni	peptidase Clp (S14 family)	0.0067	0.0734	0.0809
Trypanosoma brucei	kinesin, putative	0.0017	0.0047	0.0248
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0001	0.0003
Mycobacterium tuberculosis	Conserved protein	0.0099	0.1179	0.1374
Trypanosoma brucei	hypothetical protein, conserved	0.0099	0.1179	0.6239
Trypanosoma cruzi	kinesin, putative	0.0017	0.0047	0.0248
Schistosoma mansoni	microtubule-associated protein tau	0.0669	0.9071	1
Trypanosoma brucei	antigen, putative	0.0017	0.0047	0.0248
Mycobacterium leprae	conserved hypothetical protein	0.0099	0.1179	0.9553
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0099	0.1179	0.1374
Echinococcus granulosus	intermediate filament protein	0.0026	0.0171	0.0189
Echinococcus multilocularis	calpain	0.0017	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0059	0.0106
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0051	0.0514	0.0567
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	0.6222
Onchocerca volvulus		0.0099	0.1179	0.5124
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0099	0.1179	1
Trichomonas vaginalis	conserved hypothetical protein	0.0414	0.5535	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0367	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0059	0.0106
Plasmodium falciparum	glutathione reductase	0.0041	0.0367	0.0663
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0171	0.0308
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0248
Schistosoma mansoni	rab6-interacting	0.0018	0.0059	0.0065
Echinococcus granulosus	muscleblind protein	0.0266	0.3494	0.3852
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.212
Plasmodium vivax	hypothetical protein, conserved	0.0099	0.1179	0.2131
Schistosoma mansoni	hypothetical protein	0.0307	0.4064	0.448
Brugia malayi	calpain 5	0.0017	0.0047	0.0084
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0358	0.0395
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	1
Onchocerca volvulus	Alhambra homolog	0.0033	0.0262	0.1133
Entamoeba histolytica	hypothetical protein	0.0068	0.0747	0.135
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0017	0.0047	0.0248
Echinococcus multilocularis	arginase 2, mitochondrial	0.0414	0.5535	0.5535
Brugia malayi	hypothetical protein	0.0029	0.0206	0.037
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0367	0.3112
Loa Loa (eye worm)	calpain 5	0.0017	0.0047	0.0084
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0103	0.1229	0.1432
Trypanosoma cruzi	hypothetical protein, conserved	0.0099	0.1179	0.6239
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0331	0.0598
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0014	0.0001	0.0008
Echinococcus multilocularis	calpain 7 (C02 family)	0.0017	0.0047	0.0047
Mycobacterium tuberculosis	Probable esterase LipL	0.0099	0.1179	0.1374
Loa Loa (eye worm)	calpain	0.0017	0.0047	0.0084
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0358	0.0395
Onchocerca volvulus		0.0018	0.0059	0.0249
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0044	0.0414	0.0482
Trichomonas vaginalis	penicillin-binding protein, putative	0.0099	0.1179	0.2131
Echinococcus multilocularis		0.0414	0.5535	0.5535
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0367	0.1941
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0001	0.0003
Echinococcus granulosus	jumonji domain containing protein	0.0046	0.0441	0.0486
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0358	0.0643
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.0406	0.073
Trypanosoma cruzi	hypothetical protein, conserved	0.0099	0.1179	0.6239
Onchocerca volvulus		0.0018	0.0059	0.0249
Onchocerca volvulus		0.0099	0.1179	0.5124
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0067	0.0734	0.1326
Mycobacterium tuberculosis	Probable dehydrogenase	0.0092	0.1086	0.1265
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.212
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0023	0.0126	0.0227
Echinococcus multilocularis	survival motor neuron protein 1	0.0416	0.5563	0.5563
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0331	0.0598
Echinococcus granulosus	arginase 2 mitochondrial	0.0414	0.5535	0.6101
Schistosoma mansoni	alpha-glucosidase	0.0147	0.1843	0.2032
Mycobacterium leprae	Probable lipase LipE	0.0099	0.1179	0.9553
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.002	0.0084	0.0092
Trichomonas vaginalis	penicillin-binding protein, putative	0.0099	0.1179	0.2131
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	1
Trichomonas vaginalis	conserved hypothetical protein	0.0414	0.5535	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0262	0.0289
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0126	0.1708
Echinococcus multilocularis	geminin	0.0307	0.4064	0.4064
Onchocerca volvulus		0.0085	0.098	0.4258
Plasmodium falciparum	ataxin-2 like protein, putative	0.0045	0.0425	0.0768
Echinococcus granulosus	beta LACTamase domain containing family member	0.0099	0.1179	0.13
Loa Loa (eye worm)	hypothetical protein	0.018	0.23	0.4135
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0092	0.1086	0.1265
Schistosoma mansoni	survival motor neuron protein	0.0085	0.098	0.108
Plasmodium vivax	calpain, putative	0.0017	0.0047	0.0085
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0014	0.0001	0.0003
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0331	0.0598
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0331	0.0595
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0331	0.0598
Leishmania major	kinesin, putative	0.0017	0.0047	0.0085
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0001	0.0003
Brugia malayi	glutathione reductase	0.0041	0.0367	0.066
Plasmodium falciparum	LCCL domain-containing protein	0.0018	0.0059	0.0106
Schistosoma mansoni	hypothetical protein	0.0307	0.4064	0.448
Trichomonas vaginalis	D-aminoacylase, putative	0.0099	0.1179	0.2131
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0331	0.0595
Leishmania major	glycosyl hydrolase-like protein	0.0014	0.0001	0.0003
Trypanosoma cruzi	PAB1-binding protein , putative	0.0045	0.0425	0.225
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.212
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0001	0.0003
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0331	0.0365
Trypanosoma brucei	calpain-like protein, putative	0.0017	0.0047	0.0248
Schistosoma mansoni	lipoxygenase	0.0051	0.0514	0.0567
Brugia malayi	jmjC domain containing protein	0.0108	0.13	0.2336
Loa Loa (eye worm)	calpain family protein 1	0.0041	0.0375	0.0674
Trypanosoma cruzi	PAB1-binding protein , putative	0.0045	0.0425	0.225
Loa Loa (eye worm)	calpain family protein 1	0.0058	0.0616	0.1107
Echinococcus granulosus	calpain 5	0.0017	0.0047	0.0052
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0331	0.0598
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0258	0.3378	0.3723
Leishmania major	hypothetical protein, conserved	0.0099	0.1179	0.2131
Echinococcus granulosus	lipoxygenase domain containing protein	0.0018	0.0059	0.0065
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0171	0.0308
Echinococcus granulosus	microtubule associated protein 2	0.0669	0.9071	1
Echinococcus granulosus	calpain A	0.0017	0.0047	0.0052
Mycobacterium tuberculosis	Probable lipase LipD	0.0099	0.1179	0.1374
Schistosoma mansoni	lamin	0.0026	0.0171	0.0189
Mycobacterium tuberculosis	Conserved protein	0.0099	0.1179	0.1374
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0044	0.0414	0.0482
Loa Loa (eye worm)	doublecortin family protein	0.0018	0.0059	0.0106
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0262	0.0473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0258	0.3378	0.3723
Trypanosoma cruzi	agmatinase, putative	0.0151	0.189	1
Brugia malayi	jmjC domain containing protein	0.004	0.0358	0.0643
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0018	0.0059	0.0059
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0061	0.0657	0.0724
Brugia malayi	beta-lactamase	0.0099	0.1179	0.212
Schistosoma mansoni	calpain-7 (C02 family)	0.0017	0.0047	0.0052
Brugia malayi	Bromodomain containing protein	0.0033	0.0262	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0616	0.1107
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0331	0.0598
Echinococcus granulosus	Polycystic kidney disease protein	0.0018	0.0059	0.0065
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0262	0.2221
Echinococcus multilocularis	peregrin	0.0033	0.0262	0.0262
Trypanosoma cruzi	kinesin, putative	0.0017	0.0047	0.0248
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.0406	0.073
Mycobacterium ulcerans	esterase/lipase LipP	0.0099	0.1179	1
Schistosoma mansoni	arginase	0.0414	0.5535	0.6101
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0126	0.0227
Toxoplasma gondii	hypothetical protein	0.0023	0.0126	0.1065
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0017	0.0047	0.0248
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0061	0.0657	0.0657
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0092	0.1086	0.8705
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0017	0.0047	0.0248
Entamoeba histolytica	hypothetical protein	0.0068	0.0747	0.135
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0067	0.0734	0.0809
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0085	0.098	0.1762
Echinococcus granulosus	lipoxygenase domain containing protein	0.0018	0.0059	0.0065
Echinococcus multilocularis	RUN	0.0018	0.0059	0.0059
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	1
Echinococcus multilocularis	jumonji domain containing protein	0.0046	0.0441	0.0441
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.0358	0.0395
Toxoplasma gondii	LsmAD domain-containing protein	0.0045	0.0425	0.3606
Trypanosoma brucei	trypanothione reductase	0.0041	0.0367	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0588	0.1057
Echinococcus multilocularis	calpain 5	0.0017	0.0047	0.0047
Mycobacterium ulcerans	beta-lactamase	0.0099	0.1179	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0171	0.0308
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0171	0.2173	0.3906
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0258	0.3378	0.3723
Brugia malayi	intermediate filament protein	0.0026	0.0171	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0171	0.0308
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0099	0.1179	0.1374
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0331	0.0331
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0014	0.0001	0.0008
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0634	0.8581	1
Schistosoma mansoni	calpain C (C02 family)	0.0017	0.0047	0.0052
Onchocerca volvulus		0.0026	0.0171	0.0739
Schistosoma mansoni	alpha glucosidase	0.0038	0.0331	0.0365
Trypanosoma cruzi	agmatinase, putative	0.0151	0.189	1
Onchocerca volvulus		0.0099	0.1179	0.5124
Echinococcus multilocularis	microtubule associated protein 2	0.0669	0.9071	0.9071
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0616	0.1107
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0331	0.1751
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.212
Plasmodium falciparum	ataxin-2 like protein, putative	0.0045	0.0425	0.0768
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0068	0.0747	0.0747
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0258	0.3378	0.3723
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0171	0.2173	0.3906
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0367	0.066
Brugia malayi	Probable ClpP-like protease	0.0067	0.0734	0.1319
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0051	0.0514	0.0514
Plasmodium vivax	multidomain scavenger receptor, putative	0.0018	0.0059	0.0106
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0099	0.1179	0.1179
Brugia malayi	hypothetical protein	0.0045	0.0425	0.0764
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0002	0.0003
Schistosoma mansoni	loxhd1	0.0018	0.0059	0.0065
Trichomonas vaginalis	esterase, putative	0.0099	0.1179	0.2131
Leishmania major	trypanothione reductase	0.0041	0.0367	0.0663
Trypanosoma brucei	PAB1-binding protein , putative	0.0045	0.0425	0.225
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.212
Schistosoma mansoni	hypothetical protein	0.0085	0.098	0.108
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0067	0.0734	0.5514
Trichomonas vaginalis	D-aminoacylase, putative	0.0099	0.1179	0.2131
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0099	0.1179	0.13
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0085
Echinococcus multilocularis	musashi	0.0026	0.0171	0.0171
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.002	0.0084	0.0084
Entamoeba histolytica	hypothetical protein	0.0068	0.0747	0.135
Schistosoma mansoni	alpha-glucosidase	0.0147	0.1843	0.2032
Echinococcus granulosus	RUN	0.0018	0.0059	0.0065
Trypanosoma cruzi	arginase, putative	0.0151	0.189	1
Entamoeba histolytica	protein kinase, putative	0.0017	0.0047	0.0085
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0085
Brugia malayi	beta-lactamase family protein	0.0099	0.1179	0.212
Brugia malayi	N-terminal motif family protein	0.018	0.23	0.4135
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0331	0.0598
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0331	0.0598
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0085
Plasmodium falciparum	arginase	0.0414	0.5535	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0248
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0258	0.3378	0.3378
Brugia malayi	PHD-finger family protein	0.0033	0.0262	0.0471
Echinococcus multilocularis	lamin	0.0026	0.0171	0.0171
Trypanosoma cruzi	arginase, putative	0.0151	0.189	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0375	0.0674
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	0.1326
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.0406	0.073
Mycobacterium ulcerans	lipase LipD	0.0099	0.1179	1
Schistosoma mansoni	jumonji domain containing protein	0.0086	0.0993	0.1094
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0017	0.0047	0.0248
Echinococcus granulosus	calpain A	0.0061	0.0657	0.0724
Mycobacterium tuberculosis	Conserved protein	0.0099	0.1179	0.1374
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0258	0.3378	0.3378
Schistosoma mansoni	polycystin 1-related	0.0018	0.0059	0.0065
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0331	0.0598
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1409	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1179	0.212
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0262	0.0289
Schistosoma mansoni	rab6-interacting	0.0018	0.0059	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0262	0.0471
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0067	0.0734	0.6223
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0067	0.0734	0.0734
Schistosoma mansoni	hypothetical protein	0.0018	0.0059	0.0065
Echinococcus multilocularis	lamin dm0	0.0026	0.0171	0.0171
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0262	0.2221
Trypanosoma brucei	calpain-like protein, putative	0.0017	0.0047	0.0248
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0068	0.0747	0.0824
Schistosoma mansoni	lamin	0.0026	0.0171	0.0189
Brugia malayi	latrophilin 2 splice variant baaae	0.003	0.0216	0.0389
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0067	0.0734	0.6223
Echinococcus multilocularis	lysine specific demethylase 5A	0.004	0.0358	0.0358
Echinococcus granulosus	peptidase Clp S14 family	0.0044	0.0414	0.0457
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0044	0.0414	0.2616
Brugia malayi	beta-lactamase family protein	0.0099	0.1179	0.212
Echinococcus granulosus	lamin dm0	0.0026	0.0171	0.0189
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0262	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0406	0.073
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	0.23	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0099	0.1179	0.1374
Plasmodium vivax	ataxin-2 like protein, putative	0.0045	0.0425	0.0768
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0061	0.0657	0.0724
Onchocerca volvulus		0.0026	0.0171	0.0739
Leishmania major	hypothetical protein, conserved	0.0045	0.0425	0.0768
Brugia malayi	hypothetical protein	0.0068	0.0747	0.1343
Echinococcus granulosus	calpain 7 C02 family	0.0017	0.0047	0.0052
Brugia malayi	calpain family protein 1	0.0058	0.0616	0.1107
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.2173	0.2173
Entamoeba histolytica	hypothetical protein	0.0068	0.0747	0.135
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0017	0.0047	0.0248
Brugia malayi	hypothetical protein	0.0018	0.0059	0.0106
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0014	0.0001	0.0003
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.0367	0.0405
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0001	0.0003
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0092	0.1086	0.1265
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1409	0.2533
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0108	0.13	0.1433
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0331	0.1751
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0262	0.0289
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0067	0.0734	0.6222
Echinococcus multilocularis	Polycystic kidney disease protein	0.0018	0.0059	0.0059
Brugia malayi	Muscleblind-like protein	0.0266	0.3494	0.6282
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0002	0.0003
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0092	0.1086	0.1265
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.0748	0.1344
Mycobacterium tuberculosis	Probable oxidoreductase	0.0103	0.1229	0.1432
Entamoeba histolytica	Arginase, putative	0.0414	0.5535	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0375	0.0674

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3430 nM	Inhibition of human recombinant full length Arg1 using L-arginine as substrate assessed as urea level after 1 hr by colorimetric assay	ChEMBL.	23453840
IC50 (binding)	= 5070 nM	Inhibition of human Arg2 by colorimetric assay	ChEMBL.	23453840
Kd (binding)	= 0.88 uM	Binding affinity to human arginase 1 using L-arginine as substrate by surface plasmon resonance assay	ChEMBL.	21728378
Ki (binding)	= 260 uM	Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assay	ChEMBL.	21728378

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1812662

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1077917