Detailed information for compound 107879

Basic information

Technical information
  • TDR Targets ID: 107879
  • Name: (E)-N-hydroxy-N-methyl-3-naphthalen-2-ylprop- 2-enamide
  • MW: 227.259 | Formula: C14H13NO2
  • H donors: 1 H acceptors: 2 LogP: 2.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(O)C)/C=C/c1ccc2c(c1)cccc2
  • InChi: 1S/C14H13NO2/c1-15(17)14(16)9-7-11-6-8-12-4-2-3-5-13(12)10-11/h2-10,17H,1H3/b9-7+
  • InChiKey: CORKVTFWNIPMDF-VQHVLOKHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-N-hydroxy-N-methyl-3-(2-naphthyl)prop-2-enamide
  • (E)-N-hydroxy-N-methyl-3-(2-naphthalenyl)-2-propenamide
  • (E)-N-hydroxy-N-methyl-3-naphthalen-2-yl-prop-2-enamide
  • (E)-N-hydroxy-N-methyl-3-(2-naphthyl)acrylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0192 0.0251
Leishmania major alpha tubulin 0.021 0.2543 1
Plasmodium vivax delta tubulin, putative 0.0091 0.1038 0.3757
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0119 0.1388 0.5457
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0091 0.1038 0.3757
Schistosoma mansoni hypothetical protein 0.0427 0.5301 0.622
Leishmania major alpha tubulin 0.021 0.2543 1
Brugia malayi hypothetical protein 0.0024 0.0185 0.0643
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Mycobacterium leprae cell division protein FtsZ 0.0091 0.1038 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0984 0.0984
Schistosoma mansoni bromodomain containing protein 0.0064 0.0694 0.0764
Mycobacterium tuberculosis Cell division protein FtsZ 0.0091 0.1038 1
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Schistosoma mansoni tubulin subunit alpha 0.021 0.2543 0.2954
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.158 0.6181
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0518 0.1801
Schistosoma mansoni tubulin subunit alpha 0.021 0.2543 0.2954
Loa Loa (eye worm) tubulin gamma chain 0.021 0.2543 1
Echinococcus multilocularis acetylcholinesterase 0.0078 0.0867 0.0867
Echinococcus multilocularis peroxisome assembly protein 26 0.021 0.2543 0.2543
Plasmodium falciparum alpha tubulin 1 0.021 0.2543 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0131 0.0837
Brugia malayi CXXC zinc finger family protein 0.003 0.0263 0.0954
Echinococcus granulosus tubulin beta 4A class IVa 0.021 0.2543 0.2995
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0185 0.0726
Echinococcus granulosus carboxylesterase 5A 0.0078 0.0867 0.1021
Trypanosoma cruzi zeta tubulin, putative 0.0091 0.1038 0.3905
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0518 0.1603
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.1038 0.3965
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.2543 0.2995
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2543 0.2995
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Schistosoma mansoni tubulin subunit alpha 0.0091 0.1038 0.1171
Echinococcus granulosus tubulin gamma 1 chain 0.021 0.2543 0.2995
Echinococcus granulosus cpg binding protein 0.0034 0.0308 0.0363
Trichomonas vaginalis tubulin alpha chain, putative 0.0119 0.1388 0.5369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0065
Schistosoma mansoni alpha tubulin 0.021 0.2543 0.2954
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Plasmodium falciparum tubulin beta chain 0.021 0.2543 1
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0263 0.1033
Echinococcus granulosus zinc finger protein 0.0021 0.0148 0.0175
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin epsilon chain 0.021 0.2543 0.2543
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.2543 0.2543
Brugia malayi Tubulin alpha chain 0.021 0.2543 1
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Entamoeba histolytica tubulin alpha chain, putative 0.021 0.2543 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0185 0.0185
Echinococcus multilocularis BC026374 protein (S09 family) 0.0013 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0361 0.142
Schistosoma mansoni rab6-interacting 0.0024 0.0185 0.0161
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2543 0.2543
Trypanosoma brucei epsilon tubulin 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Giardia lamblia Delta tubulin 0.0091 0.1038 0.3757
Echinococcus granulosus tubulin subunit TubB 0.021 0.2543 0.2995
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.0865 0.0865
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0518 0.061
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0131 0.0155
Loa Loa (eye worm) hypothetical protein 0.0078 0.0867 0.3408
Brugia malayi hypothetical protein 0.0013 0.0049 0.0104
Plasmodium vivax tubulin beta chain, putative 0.021 0.2543 1
Trypanosoma brucei zeta tubulin, putative 0.0091 0.1038 0.3905
Echinococcus multilocularis tubulin gamma 1 chain 0.021 0.2543 0.2543
Brugia malayi Bromodomain containing protein 0.0075 0.084 0.3243
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Echinococcus multilocularis tubulin beta 1 chain 0.021 0.2543 0.2543
Leishmania major alpha tubulin 0.021 0.2543 1
Onchocerca volvulus 0.0087 0.0984 0.6982
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Trichomonas vaginalis tubulin, putative 0.0119 0.1388 0.5369
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0185 0.0217
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0192 0.0481
Leishmania major beta tubulin 0.021 0.2543 1
Toxoplasma gondii alpha-tubulin I, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Trypanosoma cruzi tubulin delta chain 0.0091 0.1038 0.3905
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Plasmodium falciparum tubulin gamma chain 0.021 0.2543 1
Brugia malayi Carboxylesterase family protein 0.0078 0.0867 0.335
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0518 0.0518
Trichomonas vaginalis tubulin beta chain, putative 0.0119 0.1388 0.5369
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0984 0.1107
Schistosoma mansoni tubulin subunit beta 0.0091 0.1038 0.1171
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0332
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Brugia malayi beta-tubulin, identical 0.021 0.2543 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0185 0.0217
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Echinococcus multilocularis carboxylesterase 5A 0.0078 0.0867 0.0867
Echinococcus granulosus microtubule associated protein 2 0.0678 0.8492 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.021 0.2543 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0091 0.1038 0.3965
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0518 0.1801
Brugia malayi Tubulin alpha chain 0.0091 0.1038 0.4028
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0518 0.1801
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0185 0.022
Echinococcus granulosus beta tubulin 0.021 0.2543 0.2995
Brugia malayi tubulin alpha chain - mouse 0.021 0.2543 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0192 0.0251
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0518 0.1801
Leishmania major delta tubulin, putative 0.0091 0.1038 0.3905
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Schistosoma mansoni loxhd1 0.0024 0.0185 0.0161
Trypanosoma brucei tubulin delta chain 0.0091 0.1038 0.3905
Plasmodium falciparum alpha tubulin 2 0.021 0.2543 1
Loa Loa (eye worm) carboxylesterase 0.0078 0.0867 0.3408
Loa Loa (eye worm) hypothetical protein 0.007 0.0765 0.3007
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Giardia lamblia Beta tubulin 0.021 0.2543 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0185 0.022
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0192 0.145
Echinococcus multilocularis neuroligin 0.0013 0.0049 0.0049
Leishmania major beta tubulin 0.021 0.2543 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0518 0.0556
Loa Loa (eye worm) tubulin beta chain 0.0091 0.1038 0.408
Loa Loa (eye worm) hypothetical protein 0.004 0.0391 0.1536
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.169 0.199
Giardia lamblia Beta tubulin 0.021 0.2543 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.158 0.6102
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0331 0.0389
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Leishmania major beta tubulin 0.021 0.2543 1
Brugia malayi Tubulin beta chain 0.0119 0.1388 0.5417
Echinococcus multilocularis tubulin delta chain 0.0091 0.1038 0.1038
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0185 0.0218
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0633 0.2078
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0055
Brugia malayi hypothetical protein 0.0024 0.0185 0.0643
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.158 0.6102
Trichomonas vaginalis tubulin alpha chain, putative 0.021 0.2543 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0518 0.1801
Schistosoma mansoni alpha tubulin 0.021 0.2543 0.2954
Leishmania major alpha tubulin 0.021 0.2543 1
Brugia malayi Tubulin alpha-2 chain 0.021 0.2543 1
Echinococcus multilocularis tubulin alpha 1C chain 0.021 0.2543 0.2543
Leishmania major beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0867 0.3408
Trichomonas vaginalis tubulin, putative 0.0091 0.1038 0.3965
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Brugia malayi Tubulin alpha-2 chain 0.021 0.2543 1
Leishmania major alpha tubulin 0.021 0.2543 1
Trypanosoma brucei zeta tubulin 0.0091 0.1038 0.3905
Toxoplasma gondii beta-1 tubulin, putative 0.021 0.2543 1
Echinococcus multilocularis cpg binding protein 0.0034 0.0308 0.0308
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0764
Schistosoma mansoni lipoxygenase 0.0142 0.169 0.1944
Echinococcus multilocularis tubulin subunit beta 0.021 0.2543 0.2543
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2543 0.2995
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0236
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0192 0.0251
Leishmania major alpha tubulin 0.021 0.2543 1
Loa Loa (eye worm) carboxylesterase 0.0013 0.0049 0.0191
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.2543 0.2543
Loa Loa (eye worm) BEN-1 protein 0.021 0.2543 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0984 0.3814
Echinococcus granulosus RUN 0.0024 0.0185 0.0217
Echinococcus multilocularis hypothetical protein 0.021 0.2543 0.2543
Plasmodium vivax tubulin alpha chain, putative 0.021 0.2543 1
Echinococcus granulosus Tubulin alpha 1 chain 0.021 0.2543 0.2995
Brugia malayi Doublecortin family protein 0.0024 0.0185 0.0643
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0726
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Echinococcus multilocularis tubulin alpha 3 chain 0.021 0.2543 0.2543
Brugia malayi MAP kinase sur-1 0.005 0.0518 0.1967
Schistosoma mansoni cpg binding protein 0.0034 0.0308 0.0307
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0091 0.1038 0.3757
Echinococcus multilocularis acetylcholinesterase 0.0078 0.0867 0.0867
Leishmania major zeta tubulin, putative 0.0091 0.1038 0.3905
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0098
Trypanosoma cruzi zeta tubulin, putative 0.0091 0.1038 0.3905
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0091 0.1038 0.3965
Echinococcus multilocularis RUN 0.0024 0.0185 0.0185
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Loa Loa (eye worm) alpha-tubulin 0.021 0.2543 1
Schistosoma mansoni lipoxygenase 0.01 0.1146 0.13
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0236
Loa Loa (eye worm) BEN-1 protein 0.021 0.2543 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0185 0.0217
Onchocerca volvulus 0.0024 0.0185 0.1015
Echinococcus granulosus beta tubulin 0.021 0.2543 0.2995
Echinococcus granulosus tubulin alpha chain 0.021 0.2543 0.2995
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0518 0.1801
Schistosoma mansoni tubulin subunit alpha 0.021 0.2543 0.2954
Echinococcus multilocularis zinc finger protein 0.0021 0.0148 0.0148
Leishmania major alpha tubulin 0.021 0.2543 1
Loa Loa (eye worm) beta-tubulin 0.021 0.2543 1
Leishmania major epsilon tubulin, putative 0.021 0.2543 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0331 0.0331
Giardia lamblia Epsilon tubulin 0.0091 0.1038 0.3757
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0098
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0192 0.0669
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Schistosoma mansoni hypothetical protein 0.0015 0.0073 0.0029
Trypanosoma brucei protein kinase, putative 0.005 0.0518 0.1801
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0119 0.1388 0.5369
Onchocerca volvulus 0.0119 0.1388 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0185 0.0185
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0095 0.0055
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2543 0.2543
Leishmania major beta tubulin 0.021 0.2543 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0192 0.145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0131 0.0236
Giardia lamblia Beta tubulin 0.021 0.2543 1
Giardia lamblia Gamma tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.1388 0.5457
Loa Loa (eye worm) hypothetical protein 0.0119 0.1388 0.5457
Brugia malayi Tubulin gamma chain 0.021 0.2543 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0013 0.0049 0.0049
Trypanosoma cruzi epsilon tubulin, putative 0.021 0.2543 1
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.1038 0.3965
Plasmodium vivax tubulin epsilon chain, putative 0.021 0.2543 1
Leishmania major gamma-tubulin 0.021 0.2543 1
Loa Loa (eye worm) tubulin beta-1 chain 0.021 0.2543 1
Echinococcus granulosus tubulin beta 1 chain 0.021 0.2543 0.2995
Trichomonas vaginalis tubulin, putative 0.021 0.2543 1
Loa Loa (eye worm) tubulin beta chain 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0192 0.0669
Leishmania major beta tubulin 0.021 0.2543 1
Brugia malayi Cell division protein ftsZ 0.0091 0.1038 0.4028
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0095 0.0095
Plasmodium falciparum tubulin epsilon chain, putative 0.021 0.2543 1
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Schistosoma mansoni tubulin subunit beta 0.021 0.2543 0.2954
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin subunit TubB 0.021 0.2543 0.2543
Loa Loa (eye worm) tubulin alpha chain 0.021 0.2543 1
Leishmania major alpha tubulin 0.021 0.2543 1
Entamoeba histolytica tubulin alpha-1 chain 0.021 0.2543 1
Schistosoma mansoni tubulin subunit delta 0.0091 0.1038 0.1171
Brugia malayi Tubulin beta chain 0.0091 0.1038 0.4028
Entamoeba histolytica tubulin family protein 0.021 0.2543 1
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Toxoplasma gondii beta tubulin 0.021 0.2543 1
Mycobacterium ulcerans cell division protein FtsZ 0.0091 0.1038 1
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus granulosus dnaJ subfamily B 0.0427 0.5301 0.6242
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0131 0.0837
Echinococcus multilocularis beta tubulin 0.021 0.2543 0.2543
Trypanosoma cruzi epsilon tubulin, putative 0.021 0.2543 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0518 0.061
Trichomonas vaginalis tubulin gamma chain, putative 0.021 0.2543 1
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0518 0.1603
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0065
Brugia malayi Tubulin beta-1 chain 0.021 0.2543 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0192 0.0251
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0013 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0044 0.0436 0.1715
Entamoeba histolytica hypothetical protein 0.0024 0.0192 0.0251
Toxoplasma gondii alpha tubulin TUBA1 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus granulosus alpha tubulin 0.021 0.2543 0.2995
Echinococcus granulosus tubulin alpha 0.021 0.2543 0.2995
Brugia malayi tubulin alpha-2 chain 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.158 0.6214
Echinococcus granulosus acetylcholinesterase 0.0078 0.0867 0.1021
Echinococcus multilocularis tubulin alpha chain 0.021 0.2543 0.2543
Leishmania major beta tubulin 0.021 0.2543 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0131 0.0517
Toxoplasma gondii beta-tubulin, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin gamma chain, putative 0.021 0.2543 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0013 0.0049 0.0049
Plasmodium vivax tubulin gamma chain, putative 0.021 0.2543 1
Schistosoma mansoni tubulin subunit epsilon 0.021 0.2543 0.2954
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.021 0.2543 0.2543
Schistosoma mansoni cpg binding protein 0.003 0.0263 0.0254
Echinococcus granulosus tubulin subunit beta 0.021 0.2543 0.2995
Schistosoma mansoni cpg binding protein 0.0034 0.0308 0.0307
Entamoeba histolytica tubulin gamma chain 0.021 0.2543 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0078 0.0867 0.3408
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0726
Schistosoma mansoni zinc finger protein 0.0015 0.0073 0.0029
Leishmania major beta tubulin 0.021 0.2543 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.169 0.169
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0518 0.2037
Schistosoma mansoni hypothetical protein 0.002 0.014 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0192 0.0481
Echinococcus granulosus acetylcholinesterase 0.0078 0.0867 0.1021
Plasmodium falciparum tubulin delta chain, putative 0.0091 0.1038 0.3757
Treponema pallidum cell division protein FtsZ 0.0091 0.1038 1
Echinococcus granulosus neuroligin 0.0013 0.0049 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0131 0.0131
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0332
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.021 0.2543 1
Echinococcus multilocularis beta tubulin 0.021 0.2543 0.2543
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.158 0.1861
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.8492 1
Loa Loa (eye worm) tubulin beta-2A chain 0.021 0.2543 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0103 0.0103
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Schistosoma mansoni tubulin subunit gamma 0.021 0.2543 0.2954
Schistosoma mansoni rab6-interacting 0.0024 0.0185 0.0161
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus granulosus tubulin epsilon chain 0.021 0.2543 0.2995
Loa Loa (eye worm) carboxylesterase 0.0013 0.0049 0.0191
Echinococcus granulosus Tubulin beta 2C chain 0.021 0.2543 0.2995
Loa Loa (eye worm) hypothetical protein 0.0087 0.0984 0.3868
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0185 0.0185
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.021 0.2543 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0192 0.145
Trypanosoma brucei epsilon tubulin 0.021 0.2543 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0518 0.1801
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.158 0.6102
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.1388 0.5457
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.158 0.158
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0131 0.0236
Leishmania major beta tubulin 0.021 0.2543 1
Entamoeba histolytica tubulin family protein 0.021 0.2543 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.158 0.1814
Schistosoma mansoni polycystin 1-related 0.0024 0.0185 0.0161
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.2543 0.2995
Giardia lamblia Alpha-tubulin 0.021 0.2543 1
Brugia malayi Carboxylesterase family protein 0.0078 0.0867 0.335
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Schistosoma mansoni hypothetical protein 0.0024 0.0185 0.0161
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.8492 0.8492
Trichomonas vaginalis tubulin gamma chain, putative 0.021 0.2543 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.021 0.2543 0.2543
Loa Loa (eye worm) tubulin beta-4 chain 0.021 0.2543 1
Trichomonas vaginalis tubulin, putative 0.0119 0.1388 0.5369
Loa Loa (eye worm) tubulin alpha-3 chain 0.0091 0.1038 0.408
Brugia malayi alpha-tubulin 0.021 0.2543 1
Leishmania major beta tubulin 0.021 0.2543 1
Trypanosoma brucei alpha tubulin, putative 0.0119 0.1388 0.5323
Onchocerca volvulus 0.0024 0.0185 0.1015
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0103 0.0122
Trichomonas vaginalis tubulin gamma chain, putative 0.0091 0.1038 0.3965
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0407
Loa Loa (eye worm) PHD-finger family protein 0.002 0.014 0.0549
Schistosoma mansoni alpha tubulin 0.021 0.2543 0.2954
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus granulosus transcription factor Dp 1 0.0077 0.0865 0.1019
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Leishmania major alpha tubulin 0.021 0.2543 1
Echinococcus granulosus BC026374 protein S09 family 0.0013 0.0049 0.0057
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0192 0.5
Loa Loa (eye worm) alpha-tubulin 0.021 0.2543 1
Giardia lamblia Alpha-tubulin 0.021 0.2543 1
Trypanosoma brucei alpha tubulin 0.021 0.2543 1
Trichomonas vaginalis tubulin beta chain, putative 0.021 0.2543 1
Trypanosoma cruzi alpha tubulin, putative 0.021 0.2543 1
Trichomonas vaginalis tubulin alpha chain, putative 0.021 0.2543 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.021 0.2543 1
Echinococcus multilocularis Tubulin beta 2C chain 0.021 0.2543 0.2543
Trichomonas vaginalis tubulin alpha chain, putative 0.0119 0.1388 0.5369
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0095 0.0112
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0185 0.0162
Echinococcus granulosus tubulin alpha 1C chain 0.021 0.2543 0.2995
Brugia malayi Bromodomain containing protein 0.0038 0.036 0.134
Echinococcus granulosus tubulin alpha 3 chain 0.021 0.2543 0.2995
Schistosoma mansoni zinc finger protein 0.0021 0.0148 0.0118
Echinococcus granulosus tubulin delta chain 0.0091 0.1038 0.1222
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0119 0.1388 0.5369
Trichomonas vaginalis tubulin alpha chain, putative 0.0119 0.1388 0.5369
Trichomonas vaginalis tubulin epsilon chain, putative 0.021 0.2543 1
Trypanosoma brucei tubulin gamma chain 0.021 0.2543 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.158 0.6102
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.5301 0.5301
Trypanosoma brucei epsilon tubulin 0.021 0.2543 1
Plasmodium vivax tubulin alpha chain, putative 0.021 0.2543 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0867 0.0969
Onchocerca volvulus 0.003 0.0263 0.1599
Brugia malayi PHD-finger family protein 0.0026 0.0215 0.0764
Loa Loa (eye worm) hypothetical protein 0.0091 0.1038 0.408
Trypanosoma cruzi tubulin delta chain 0.0091 0.1038 0.3905
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0518 0.1882
Echinococcus multilocularis tubulin alpha 0.021 0.2543 0.2543
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0185 0.0185
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0091 0.1038 0.3965
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0103 0.0404
Trypanosoma cruzi tubulin gamma chain 0.021 0.2543 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0518 0.0518
Brugia malayi Carboxylesterase family protein 0.0013 0.0049 0.0104
Trypanosoma brucei beta tubulin 0.021 0.2543 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0984 0.1158
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.158 0.6008
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0131 0.0433
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0689 0.0759
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0091 0.1038 1
Loa Loa (eye worm) tubulin alpha chain 0.021 0.2543 1
Trypanosoma cruzi beta tubulin, putative 0.021 0.2543 1
Echinococcus granulosus para nitrobenzyl esterase 0.0013 0.0049 0.0057
Echinococcus granulosus peroxisome assembly protein 26 0.021 0.2543 0.2995

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) ChEMBL. 2308149
IC50 (binding) = 0.1 uM In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) ChEMBL. 2308149
IC50 (binding) = 0.1 uM In vitro inhibitory activity against 5-lipoxygenase in rat RBL-1 cells ChEMBL. 3669019
IC50 (binding) = 0.1 uM In vitro inhibitory activity against RBL-1 5-LO ChEMBL. 3820229
IC50 (binding) = 0.1 uM In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) ChEMBL. 2308149
IC50 (binding) = 0.1 uM In vitro inhibitory activity against 5-lipoxygenase in rat RBL-1 cells ChEMBL. 3669019
IC50 (binding) = 0.1 uM In vitro inhibitory activity against RBL-1 5-LO ChEMBL. 3820229
Inhibition (functional) = 66 % Inhibition of leukotriene biosynthesis was determined in vivo with the rat peritoneal anaphylaxis model administered perorally at 100 mg/kg *p > 0.05 ChEMBL. 3669019
Log 1/IC50 (binding) = 7 Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) ChEMBL. 2308149

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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