TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 329.252 | Formula: C17H14O2Se
H donors: 0 H acceptors: 1 LogP: 3.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1[se]c2c(c1c1ccccc1)cccc2
InChi: 1S/C17H14O2Se/c1-2-19-17(18)16-15(12-8-4-3-5-9-12)13-10-6-7-11-14(13)20-16/h3-11H,2H2,1H3
InChiKey: IRDIVODOVVBPAI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0016	0.0016
Brugia malayi	Peptidase family M1 containing protein	0.0122	0.0459	0.1008
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0122	0.0459	0.0459
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0122	0.0459	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0016	0.0035
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0122	0.0459	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0016	0.0016
Echinococcus granulosus	Niemann Pick C1 protein	0.0298	0.1229	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0165	0.0165
Brugia malayi	TAR-binding protein	0.0126	0.0476	0.1045
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0122	0.0459	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0014	0.0096
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0038	0.0554
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0122	0.0459	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0088	0.0088
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.002	0.0009	0.0009
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0038	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0459	0.0459
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0122	0.0459	0.0459
Entamoeba histolytica	hypothetical protein	0.004	0.0098	0.1019
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0016	0.0016
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0016	0.0016
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0122	0.0459	1
Brugia malayi	TATA binding protein associated factor	0.0122	0.0459	0.1008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0336	0.0336
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0016	0.0035
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0151	0.0588	0.0588
Echinococcus multilocularis	snurportin 1	0.0297	0.1228	0.1228
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0016	0.0016
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0038	0.0644
Toxoplasma gondii	aminopeptidase n, putative	0.0122	0.0459	1
Plasmodium falciparum	importin beta, putative	0.0028	0.0046	0.0813
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0088	0.0088
Schistosoma mansoni	hypothetical protein	0.004	0.0098	0.0098
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0336	0.0336
Echinococcus granulosus	expressed conserved protein	0.0196	0.0782	0.0782
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0038	0.0299
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0038	0.0644
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0016	0.0016
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0122	0.0459	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0009	0.0009
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0038	0.0299
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0476	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0016	0.0035
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0016	0.0016
Onchocerca volvulus		0.0122	0.0459	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0086	0.0302	0.0302
Onchocerca volvulus		0.0122	0.0459	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0016	0.0016
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0122	0.0459	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0046	0.0724
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0016	0.0035
Entamoeba histolytica	aminopeptidase, putative	0.0122	0.0459	0.5408
Brugia malayi	hypothetical protein	0.0122	0.0459	0.1008
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0212	0.0851	0.0851
Leishmania major	hypothetical protein, conserved	0.0024	0.0031	0.0379
Schistosoma mansoni	coup transcription factor	0.0021	0.0016	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0016	0.0035
Brugia malayi	RNA binding protein	0.0126	0.0476	0.1045
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0016	0.0016
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0031	0.0379
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0038	0.0644
Trichomonas vaginalis	conserved hypothetical protein	0.0089	0.0316	0.6783
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.0476	0.0476
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0038	0.5
Brugia malayi	steroid hormone receptor	0.0021	0.0016	0.0035
Echinococcus multilocularis	protein patched	0.0089	0.0316	0.0316
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0038	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0108	0.2193
Onchocerca volvulus		0.0122	0.0459	1
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0459	0.0459
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.0476	0.0476
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.0086	0.0302	0.0302
Brugia malayi	CHE-14 protein	0.0089	0.0316	0.0693
Brugia malayi	acetyltransferase, GNAT family protein	0.0156	0.0607	0.1332
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0023	0.0205
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0108	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0336	0.0336
Brugia malayi	hypothetical protein	0.0024	0.0031	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0016	0.0035
Entamoeba histolytica	hypothetical protein	0.004	0.0098	0.1019
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0016	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0016	0.0035
Schistosoma mansoni	patched 1	0.0089	0.0316	0.0316
Brugia malayi	hypothetical protein	0.1056	0.4556	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0016	0.0035
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0156	0.0607	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0038
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0476	0.0476
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0016	0.0016
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0476	0.0476
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0208	0.0837	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0038	0.0299
Trypanosoma cruzi	aminopeptidase, putative	0.0122	0.0459	1
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0023	0.0205
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0031	0.0471
Echinococcus multilocularis	Niemann Pick C1 protein	0.0208	0.0837	0.0837
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0122	0.0459	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0014	0.0014
Brugia malayi	nuclear hormone receptor	0.0021	0.0016	0.0035
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0122	0.0459	1
Schistosoma mansoni	hypothetical protein	0.0297	0.1228	0.1228
Entamoeba histolytica	hypothetical protein	0.004	0.0098	0.1019
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0023	0.0205
Loa Loa (eye worm)	hypothetical protein	0.011	0.0404	0.0404
Trypanosoma brucei	aminopeptidase, putative	0.0122	0.0459	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0089	0.0316	0.0316
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0046	0.0813
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0038	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0016	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0316	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0016	0.0035
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.0476	0.0476
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0165	0.0361
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0009	0.139
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0122	0.0459	1
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0122	0.0459	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0122	0.0459	1
Brugia malayi	ecdysteroid receptor	0.0021	0.0016	0.0035
Brugia malayi	hypothetical protein	0.0122	0.0459	0.1008
Loa Loa (eye worm)	hypothetical protein	0.002	0.0009	0.0009
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0125	0.2493
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0125	0.2493
Brugia malayi	RNA, U transporter 1	0.0079	0.0271	0.0595
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0476	0.0476
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0031	0.0379
Onchocerca volvulus		0.0026	0.0038	0.0508
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0038	0.0644
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0038	0.0554
Trypanosoma brucei	Aminopeptidase M1, putative	0.0122	0.0459	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0038	0.0084
Echinococcus multilocularis	Niemann Pick C1 protein	0.0298	0.1229	0.1229
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0125	0.2493
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0038	0.5
Mycobacterium ulcerans	aminopeptidase N PepN	0.0122	0.0459	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0038	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0122	0.0459	0.0459
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0016	0.0016
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0122	0.0459	0.0459
Echinococcus multilocularis	protein dispatched 1	0.0102	0.0371	0.0371
Trypanosoma cruzi	aminopeptidase, putative	0.0122	0.0459	1
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0016	0.0016
Schistosoma mansoni	ran	0.0021	0.0014	0.0014
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0016	0.0016
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0016	0.0016
Echinococcus granulosus	Niemann Pick C1 protein	0.0208	0.0837	0.0837
Brugia malayi	Peptidase family M1 containing protein	0.0122	0.0459	0.1008
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0046	0.0046
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0046	0.0724
Brugia malayi	Peptidase family M1 containing protein	0.0122	0.0459	0.1008
Echinococcus granulosus	snurportin 1	0.0297	0.1228	0.1228
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0016	0.0035
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0031	0.0379
Entamoeba histolytica	hypothetical protein	0.004	0.0098	0.1019
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0031	0.0471
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0016	0.0035
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0336	0.0336
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0165	0.0361
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0336	0.0336
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0016	0.0016
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0098	0.0098
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0016	0.0016
Echinococcus multilocularis	sterol regulatory element binding protein	0.0089	0.0316	0.0316
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0122	0.0459	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0009	0.5
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0122	0.0459	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0125	0.2565
Echinococcus granulosus	aminopeptidase N	0.0122	0.0459	0.0459
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0038	0.0084
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0122	0.0459	0.0459
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0459	0.0459
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0894	0.3843	0.3843
Trypanosoma brucei	Aminopeptidase M1, putative	0.0122	0.0459	1
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0031	0.0031
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0014	0.0096
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0098	0.0098
Toxoplasma gondii	aminopeptidase N protein	0.0122	0.0459	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0122	0.0459	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0156	0.0607	0.0607
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0016	0.0035
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0122	0.0459	1
Echinococcus granulosus	tar DNA binding protein	0.0126	0.0476	0.0476
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0016	0.0035
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0046	0.0724
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0016	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0016	0.0016
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0016	0.0035
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0016	0.0016
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.0336	0.0736
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.0476	0.0476
Schistosoma mansoni	hypothetical protein	0.0086	0.0302	0.0302
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0016	0.0016
Brugia malayi	Niemann-Pick C1 protein precursor	0.0208	0.0837	0.1838
Brugia malayi	hypothetical protein	0.004	0.0098	0.0214
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Loa Loa (eye worm)	aminopeptidase N	0.0122	0.0459	0.0459
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0122	0.0459	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0336	0.0336
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0016	0.0016
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0016	0.0035
Echinococcus granulosus	Protein patched homolog 1	0.0089	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0046	0.0046
Entamoeba histolytica	hypothetical protein	0.0023	0.0023	0.0111
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0098	0.0098
Schistosoma mansoni	ran	0.0021	0.0014	0.0014
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0108	0.1145
Loa Loa (eye worm)	TATA binding protein associated factor	0.0122	0.0459	0.0459
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0016	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0038
Echinococcus multilocularis	aminopeptidase N	0.0122	0.0459	0.0459
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0038	0.0644
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0016	0.0016
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0014	0.003
Schistosoma mansoni	hypothetical protein	0.0086	0.0302	0.0302
Toxoplasma gondii	aminopeptidase N, putative	0.0122	0.0459	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0014	0.0014
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0089	0.0316	0.0316
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0165	0.0165
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0016	0.0016
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0023	0.0205
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.0476	0.1045
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0016	0.0016
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.0336	0.0336
Brugia malayi	Importin beta-1 subunit	0.0028	0.0046	0.0101
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0014	0.0014
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0122	0.0459	0.0459
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0122	0.0459	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0016	0.0016
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0016	0.0016
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0016	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0016	0.0016
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0038	0.0644
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0031	0.0471
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0031	0.0379
Loa Loa (eye worm)	RNA binding protein	0.0126	0.0476	0.0476
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0016	0.0016
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	0.1228	0.1228
Loa Loa (eye worm)	acetyltransferase	0.0156	0.0607	0.0607
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0038	0.0644
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0023	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0208	0.0837	0.0837
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0122	0.0459	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0016	0.0016
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0125	0.2493
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0088	0.0194
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Echinococcus multilocularis	expressed conserved protein	0.0196	0.0782	0.0782
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0038	0.0644
Loa Loa (eye worm)	hypothetical protein	0.002	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.002	0.0009	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0336	0.0336
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0122	0.0459	0.0459
Schistosoma mansoni	importin beta-1	0.0028	0.0046	0.0046
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0016	0.0016

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 23 %	Cytotoxicity against mouse MG-22A cells assessed as nitric oxide concentration at 100 ug/ml after 72 hrs by crystal violet coloration assay (Rvb = 100%)	ChEMBL.	21621884
Activity (functional)	= 25 %	Cytotoxicity against human HT1080 cells assessed as nitric oxide concentration at 100 ug/ml after 72 hrs by crystal violet coloration assay (Rvb = 100%)	ChEMBL.	21621884
LD50 (ADMET)	= 362 ug ml-1	Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by MTT assay	ChEMBL.	21621884
TD50 (ADMET)	= 16 ug ml-1	Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by MTT assay	ChEMBL.	21621884
TD50 (functional)	= 65 ug ml-1	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	ChEMBL.	21621884

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1812627

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1078900