Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0196 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0618 | 0.5814 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0618 | 0.5814 | 1 |
Giardia lamblia | Hypothetical protein | 0.0618 | 0.5814 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0618 | 0.5814 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.103 | 0.9828 | 0.9824 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.0583 | 0.0479 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0231 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0196 | 0.0196 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0196 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0196 | 0.3362 |
Loa Loa (eye worm) | hypothetical protein | 0.0601 | 0.5641 | 0.5641 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0259 | 0.4436 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0231 | 0.3965 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0196 | 0.0196 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0231 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0583 | 0.0583 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.103 | 0.9828 | 0.9824 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0583 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.0583 | 0.0583 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0583 | 0.0395 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0196 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0583 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0109 | 0.0109 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0196 | 0.0088 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0196 | 0.3362 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0196 | 0.0196 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.103 | 0.9828 | 0.9824 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0196 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0231 | 0.0036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0231 | 0.0124 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0196 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.103 | 0.9828 | 0.9824 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0196 | 0.0196 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0196 | 0.0088 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0259 | 0.4436 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.0583 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.103 | 0.9828 | 0.9828 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0618 | 0.5814 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0447 | 0.4144 | 0.4027 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0583 | 0.0583 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0447 | 0.4144 | 0.4027 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0269 | 0.241 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0109 | 0.1867 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0196 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0231 | 0.0036 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0583 | 0.0395 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0447 | 0.4144 | 0.4027 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0196 | 0.0196 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.0583 | 0.0395 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0196 | 0.3362 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0583 | 0.0395 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0196 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0231 | 0.0124 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0196 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0196 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.0583 | 0.0395 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0196 | 0.3362 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0583 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0447 | 0.4144 | 0.4027 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0231 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0259 | 0.0259 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0196 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0231 | 0.0124 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.446 microM | Inhibition of AChE from rat cortex by Ellman assay | ChEMBL. | 19954865 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.