Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase | 0.0074 | 0.1073 | 0.213 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.1073 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.1073 | 0.213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.2516 | 1 |
Schistosoma mansoni | lamin | 0.0056 | 0.0673 | 0.0178 |
Echinococcus granulosus | tumor protein p63 | 0.0375 | 0.7771 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.1073 | 0.5 |
Brugia malayi | RNA binding protein | 0.0139 | 0.2516 | 0.5256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.2516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1073 | 0.228 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0139 | 0.2516 | 0.5346 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.0673 | 0.1263 |
Brugia malayi | Peptidase family M28 containing protein | 0.0136 | 0.2456 | 0.5125 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.1073 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.1073 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 0.2456 | 0.9678 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.064 | 0.1359 |
Onchocerca volvulus | 0.0074 | 0.1073 | 0.2387 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0139 | 0.2516 | 0.5256 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.2516 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.0673 | 0.1263 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.1073 | 0.231 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1073 | 0.228 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0074 | 0.1073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0023 | 0.0049 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.1073 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.009 | 0.0191 |
Toxoplasma gondii | ABC1 family protein | 0.0074 | 0.1073 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.1073 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 0.2456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.065 | 0.1381 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.1073 | 0.228 |
Onchocerca volvulus | 0.0074 | 0.1073 | 0.2387 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.1073 | 0.1355 |
Loa Loa (eye worm) | RNA binding protein | 0.0139 | 0.2516 | 0.5346 |
Brugia malayi | TAR-binding protein | 0.0139 | 0.2516 | 0.5256 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.1073 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0238 | 0.4707 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.2516 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0238 | 0.4707 | 1 |
Schistosoma mansoni | lamin | 0.0056 | 0.0673 | 0.0178 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.0673 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0673 | 0.143 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.1073 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.0673 | 0.0839 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.1073 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.1073 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0139 | 0.2516 | 0.5346 |
Echinococcus multilocularis | tar DNA binding protein | 0.0139 | 0.2516 | 0.3218 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1073 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.2456 | 0.5218 |
Onchocerca volvulus | 0.0074 | 0.1073 | 0.2387 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.1073 | 0.231 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0238 | 0.4707 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.2516 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.0673 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1073 | 0.228 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.1073 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.1073 | 0.1355 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.0673 | 0.143 |
Onchocerca volvulus | 0.0056 | 0.0673 | 0.0184 | |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.0673 | 0.0178 |
Echinococcus granulosus | lamin | 0.0056 | 0.0673 | 0.0839 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.1073 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.0673 | 0.0184 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.1073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1073 | 0.228 |
Echinococcus granulosus | tar DNA binding protein | 0.0139 | 0.2516 | 0.3218 |
Echinococcus multilocularis | musashi | 0.0056 | 0.0673 | 0.0839 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 0.2456 | 0.314 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.0673 | 0.143 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.1073 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1073 | 0.228 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.1073 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.1073 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 0.2456 | 0.314 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.1073 | 0.213 |
Echinococcus multilocularis | tumor protein p63 | 0.0375 | 0.7771 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.1073 | 0.5 |
Echinococcus multilocularis | lamin | 0.0056 | 0.0673 | 0.0839 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.1073 | 0.213 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.1073 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1090 nM | Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assay | ChEMBL. | 19863057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.