Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0221 | 0.1426 | 0.1426 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0221 | 0.1426 | 0.1469 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0135 | 0.0777 | 0.0777 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0438 | 0.3057 | 0.3358 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0221 | 0.1426 | 0.1469 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0061 | 0.0218 | 0.0353 |
Onchocerca volvulus | 0.0221 | 0.1426 | 0.5189 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0221 | 0.1426 | 0.1426 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0135 | 0.0777 | 0.0717 |
Echinococcus multilocularis | muscleblind protein | 0.013 | 0.0737 | 0.0671 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0264 | 0.1748 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0264 | 0.1748 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0264 | 0.1748 | 0.1842 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0074 | 0.0314 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0737 | 0.2156 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0221 | 0.1426 | 0.5189 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0221 | 0.1426 | 0.1289 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0221 | 0.1426 | 0.1426 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0438 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0234 | 0.0069 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0264 | 0.1748 | 0.6475 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0221 | 0.1426 | 0.1426 |
Brugia malayi | conserved hypotetical protein | 0.0061 | 0.0218 | 0.0353 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0221 | 0.1426 | 0.5189 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0221 | 0.1426 | 0.1469 |
Schistosoma mansoni | nuclear hormone receptor | 0.0221 | 0.1426 | 0.1426 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0135 | 0.0777 | 0.0629 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 0.1572 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0221 | 0.1426 | 0.5189 |
Brugia malayi | nuclear receptor NHR-67 | 0.0061 | 0.0218 | 0.0353 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0221 | 0.1426 | 0.1289 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0221 | 0.1426 | 0.1289 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0221 | 0.1426 | 0.1289 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0061 | 0.0218 | 0.0218 |
Onchocerca volvulus | 0.0061 | 0.0218 | 0.0353 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0221 | 0.1426 | 0.5013 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0129 | 0.0129 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0264 | 0.1748 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0061 | 0.0218 | 0.0353 |
Brugia malayi | nuclear receptor NHR-88 | 0.0221 | 0.1426 | 0.5189 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.0218 | 0.0061 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0074 | 0.0314 | 0.0159 |
Schistosoma mansoni | nuclear receptor | 0.0061 | 0.0218 | 0.0218 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0221 | 0.1426 | 0.1289 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0686 | 0.2229 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0221 | 0.1426 | 0.5189 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0221 | 0.1426 | 0.1469 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0053 | 0.0158 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0061 | 0.0218 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0161 | 0.0969 | 0.3359 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.1569 | 0.1434 |
Brugia malayi | ecdysone receptor | 0.0061 | 0.0218 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0737 | 0.2156 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0674 | 0.1892 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0969 | 0.3117 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.1353 | 0.4708 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0053 | 0.0158 | 0.0158 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0264 | 0.1748 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0381 | 0.2628 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0381 | 0.2628 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0438 | 0.3057 | 0.2946 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0221 | 0.1426 | 0.5189 |
Schistosoma mansoni | nuclear receptor | 0.0061 | 0.0218 | 0.0218 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.0218 | 0.007 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0221 | 0.1426 | 0.5189 |
Schistosoma mansoni | gabp alpha | 0.0074 | 0.0314 | 0.0314 |
Brugia malayi | nuclear receptor RXR | 0.0061 | 0.0218 | 0.0353 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0221 | 0.1426 | 0.5013 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0264 | 0.1748 | 0.1748 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0221 | 0.1426 | 0.5189 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0969 | 0.3117 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.0869 | 0.0869 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0221 | 0.1426 | 0.5013 |
Onchocerca volvulus | 0.0061 | 0.0218 | 0.0353 | |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0084 | 0.0389 | 0.0268 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.1569 | 0.1635 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0221 | 0.1426 | 0.1289 |
Echinococcus multilocularis | muscleblind protein 1 | 0.013 | 0.0737 | 0.0671 |
Brugia malayi | hypothetical protein | 0.0241 | 0.1569 | 0.5763 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0135 | 0.0777 | 0.259 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0537 | 0.1325 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0061 | 0.0218 | 0.007 |
Brugia malayi | Fli-1 protein | 0.0224 | 0.1442 | 0.5254 |
Echinococcus granulosus | FTZ F1 alpha | 0.0221 | 0.1426 | 0.1289 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0218 | 0.0353 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0061 | 0.0218 | 0.007 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0161 | 0.0969 | 0.0969 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0221 | 0.1426 | 0.5189 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0061 | 0.0218 | 0.0353 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0161 | 0.0969 | 0.0969 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0061 | 0.0218 | 0.0353 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0969 | 0.3117 |
Brugia malayi | Muscleblind-like protein | 0.013 | 0.0737 | 0.2433 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0221 | 0.1426 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1201 | 0.8792 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0061 | 0.0218 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0969 | 0.3117 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0061 | 0.0218 | 0.0218 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0061 | 0.0218 | 0.0061 |
Schistosoma mansoni | nuclear hormone receptor | 0.0061 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0674 | 0.1892 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | fli-1 protein | 0.0224 | 0.1442 | 0.508 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0061 | 0.0218 | 0.0218 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0161 | 0.0969 | 0.0824 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0221 | 0.1426 | 0.1289 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0161 | 0.0969 | 0.3359 |
Schistosoma mansoni | ets-related | 0.0224 | 0.1442 | 0.1442 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0135 | 0.0777 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0971 | 0.3125 |
Schistosoma mansoni | thyroid hormone receptor | 0.0221 | 0.1426 | 0.1426 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0537 | 0.1631 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0221 | 0.1426 | 0.1426 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0053 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0686 | 0.1945 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0061 | 0.0218 | 0.0353 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0674 | 0.2178 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0135 | 0.0777 | 0.2319 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0264 | 0.1748 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0053 | 0.0158 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0074 | 0.0314 | 0.0182 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0221 | 0.1426 | 0.1426 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0053 | 0.0158 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0221 | 0.1426 | 0.1426 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0084 | 0.0389 | 0.0389 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0221 | 0.1426 | 0.1469 |
Brugia malayi | tailless protein | 0.0061 | 0.0218 | 0.0353 |
Onchocerca volvulus | 0.0241 | 0.1572 | 0.5775 | |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0314 | 0.074 |
Echinococcus granulosus | muscleblind protein | 0.013 | 0.0737 | 0.0589 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0061 | 0.0218 | 0.0353 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0061 | 0.0218 | 0.0353 |
Schistosoma mansoni | nuclear hormone receptor | 0.0061 | 0.0218 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0129 | 0.0129 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0061 | 0.0218 | 0.0353 |
Schistosoma mansoni | coup transcription factor | 0.0221 | 0.1426 | 0.1426 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0061 | 0.0218 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0218 | 0.0353 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0061 | 0.0218 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.2628 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0135 | 0.0777 | 0.259 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0686 | 0.1945 |
Onchocerca volvulus | 0.0084 | 0.0389 | 0.1038 | |
Brugia malayi | steroid hormone receptor | 0.0221 | 0.1426 | 0.5189 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.0869 | 0.0869 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0221 | 0.1426 | 0.1426 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0161 | 0.0969 | 0.3359 |
Schistosoma mansoni | zinc finger protein | 0.0061 | 0.0218 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0389 | 0.071 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0084 | 0.0389 | 0.1038 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0221 | 0.1426 | 0.1469 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0221 | 0.1426 | 0.1469 |
Brugia malayi | nuclear receptor RXR | 0.0161 | 0.0969 | 0.3359 |
Brugia malayi | nuclear hormone receptor | 0.0221 | 0.1426 | 0.5189 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0264 | 0.1748 | 0.1615 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0061 | 0.0218 | 0.0353 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0061 | 0.0218 | 0.007 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0221 | 0.1426 | 0.5189 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1569 | 0.5608 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0221 | 0.1426 | 0.5013 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0314 | 0.074 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0221 | 0.1426 | 0.1426 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0221 | 0.1426 | 0.1469 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0686 | 0.2229 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1362 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0221 | 0.1426 | 0.5189 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0686 | 0.2229 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0053 | 0.0158 | 0.0158 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0221 | 0.1426 | 0.5189 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0084 | 0.0389 | 0.0235 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0161 | 0.0969 | 0.3117 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0061 | 0.0218 | 0.007 |
Echinococcus granulosus | geminin | 0.0147 | 0.0869 | 0.0722 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0221 | 0.1426 | 0.5189 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.1353 | 0.4895 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0161 | 0.0969 | 0.094 |
Echinococcus multilocularis | geminin | 0.0147 | 0.0869 | 0.0823 |
Brugia malayi | hypothetical protein | 0.0161 | 0.0969 | 0.3359 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0061 | 0.0218 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0969 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 21 % | Percentage inhibition of murine protein phosphatase 2A at 1 mM. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.