Detailed information for compound 1079194

Basic information

Technical information
  • TDR Targets ID: 1079194
  • Name: STK098200
  • MW: 286.455 | Formula: C19H30N2
  • H donors: 0 H acceptors: 0 LogP: 5.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCn1c2CCCc2c(=N)c2c1CCC2
  • InChi: 1S/C19H30N2/c1-2-3-4-5-6-7-14-21-17-12-8-10-15(17)19(20)16-11-9-13-18(16)21/h20H,2-14H2,1H3
  • InChiKey: NKYJDOLHVMIKGE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0066 0.0066
Schistosoma mansoni metabotropic glutamate receptor 0.0036 0.0038 0.0038
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0008 0.0008
Echinococcus granulosus g protein coupled receptor 0.0057 0.0066 0.0066
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0008 0.0008
Plasmodium falciparum glutathione reductase 0.0054 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi putative neuropeptide receptor 0.0057 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0066 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0066 0.0066
Schistosoma mansoni sodium-bile acid cotransporter 0.4518 0.5941 0.5941
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0028 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0066 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0061 0.0061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.003 0.003 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0061 1
Schistosoma mansoni amine GPCR 0.0057 0.0066 0.0066
Echinococcus granulosus cpg binding protein 0.003 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0015 0.2428
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0066 0.0066
Echinococcus granulosus dnaJ subfamily B 0.0403 0.0521 0.0521
Schistosoma mansoni biogenic amine receptor 0.0057 0.0066 0.0066
Schistosoma mansoni neuropeptide receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Echinococcus multilocularis somatostatin receptor 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0066 0.0066
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0015 0.6463
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0061 1
Echinococcus multilocularis cpg binding protein 0.003 0.003 0.003
Onchocerca volvulus 0.0057 0.0066 0.0039
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni opsin-like receptor 0.0057 0.0066 0.0066
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0066 0.0066
Schistosoma mansoni amine GPCR 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni amine GPCR 0.0057 0.0066 0.0066
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0015 0.2428
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0015 0.0863
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0066 0.0066
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Echinococcus granulosus tm gpcr rhodopsin 0.1652 0.2166 0.2166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1652 0.2166 0.2166
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0015 0.6386
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis sex peptide receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0066 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0066 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0066 0.0066
Echinococcus granulosus metabotropic glutamate receptor 2 0.0036 0.0038 0.0038
Brugia malayi Serotonin receptor 0.0057 0.0066 0.0066
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.2399
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0015 0.6463
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0002 0.0002
Echinococcus granulosus orexin receptor type 2 0.0057 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0066 0.0066
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0066 0.0066
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0023 1
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0053 0.0061 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0066 0.0066
Brugia malayi larval opioid receptor 0.0057 0.0066 0.0066
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0066 0.0066
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0023 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.017 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0057 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0025 0.0023 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0061 0.9975
Onchocerca volvulus 0.0057 0.0066 0.0039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0066 0.0066
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0023 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi Metabotropic glutamate receptor precursor. 0.0043 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi metabotropic glutamate receptor type 2 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus somatostatin receptor 0.0057 0.0066 0.0066
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0061 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Echinococcus granulosus neuropeptide receptor 0.0057 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0066 0.0066
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0066 0.0066
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0066 0.0066
Echinococcus granulosus metabotropic glutamate receptor 5 0.0053 0.0061 0.0061
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0039 0.0042 0.0042
Schistosoma mansoni opsin-like receptor 0.0057 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0066 0.0066
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi neuropeptide F receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0066 0.0066
Echinococcus granulosus sex peptide receptor 0.0057 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0015
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0023 1
Onchocerca volvulus 0.0057 0.0066 0.0039
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0066 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0066 0.0066
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0066 0.0066
Treponema pallidum NADH oxidase 0.0019 0.0015 0.0214
Schistosoma mansoni amine GPCR 0.0057 0.0066 0.0066
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0015 1
Onchocerca volvulus 0.0057 0.0066 0.0039
Brugia malayi CXXC zinc finger family protein 0.0028 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0066 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0066 0.0066
Brugia malayi glutathione reductase 0.0054 0.0061 0.0061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.2428
Onchocerca volvulus 0.0057 0.0066 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Brugia malayi Thioredoxin reductase 0.0054 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0088 0.0106 0.0106
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0015 0.0015
Brugia malayi Serotonin receptor 0.0057 0.0066 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0015 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.017 1
Onchocerca volvulus 0.0057 0.0066 0.0039
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0015 0.2399
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0015 0.2399
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Schistosoma mansoni neuropeptide receptor 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0088 0.0106 0.0079
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0015 0.2428
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0106 0.0106
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0066 0.0066
Plasmodium vivax glutathione reductase, putative 0.0054 0.0061 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0015 0.2399
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0015 0.0015
Schistosoma mansoni histamine h1 receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0997 0.1303 0.1303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0066 0.0066
Brugia malayi Dopamine receptor 0.0057 0.0066 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0066 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0066 0.0066
Brugia malayi Melatonin receptor type 1A 0.0057 0.0066 0.0066
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0066 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0015 0.0214
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni myosin xvIII 0.0057 0.0066 0.0066
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0152 0.8939
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0011 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0066 0.0066
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0066 0.0039
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.003 0.003 0.003
Brugia malayi Dopamine receptor protein 2 0.0057 0.0066 0.0066
Brugia malayi GnHR receptor homolog 0.0978 0.1278 0.1278
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi RE15519p 0.0057 0.0066 0.0066
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Leishmania major trypanothione reductase 0.0054 0.0061 1
Echinococcus granulosus g protein coupled receptor 0.0057 0.0066 0.0066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0152 0.8939
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.2428
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0066 0.0066
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0015 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0015 0.6463
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0023 0.3757
Echinococcus granulosus fmrfamide receptor 0.0057 0.0066 0.0066
Brugia malayi follicle stimulating hormone receptor 0.0301 0.0387 0.0387
Mycobacterium tuberculosis Probable reductase 0.0122 0.0152 0.8939
Brugia malayi neuropeptide F receptor 0.0057 0.0066 0.0066
Trypanosoma brucei trypanothione reductase 0.0054 0.0061 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Schistosoma mansoni neuropeptide receptor 0.0997 0.1303 0.1303
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0069 0.0069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.2428
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.2428
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0015 0.0214
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0053 0.0061 0.0061
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0036 0.0038 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Brugia malayi ORL1-like opioid receptor 0.0057 0.0066 0.0066
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0023 1
Echinococcus multilocularis G protein coupled receptor 139 0.0997 0.1303 0.1303
Schistosoma mansoni adenoreceptor 0.0057 0.0066 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0066 0.0066
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0057 0.0066 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0023 0.1352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0066 0.0066
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0023 0.3757
Onchocerca volvulus 0.0057 0.0066 0.0039
Schistosoma mansoni amine GPCR 0.0057 0.0066 0.0066
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0301 0.0387 0.0387
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0066 0.0066
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0023 0.3757
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0015 0.0015
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0066 0.0066
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0066 0.0066
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0066 0.0066
Schistosoma mansoni sodium-bile acid cotransporter related 0.3082 0.4049 0.4049
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0015 0.2428
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0066 0.0066
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.0018 0.0018
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0049 0.0055 0.0055
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0106 0.0106
Echinococcus granulosus g protein coupled receptor 0.0057 0.0066 0.0066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0152 0.8939
Echinococcus granulosus hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0066 0.0066
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0066 0.0066
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0066 0.0066
Loa Loa (eye worm) glutamate receptor 0.0043 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0057 0.0066 0.0066
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.017 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0011 0.0005 0.0005
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0066 0.0066
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0015 0.0874
Toxoplasma gondii exonuclease III APE 0.0018 0.0015 0.2399
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Brugia malayi sulfakinin receptor protein 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0015 0.2428
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0066 0.0066
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0152 0.8939
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0023 0.3757
Schistosoma mansoni neuropeptide receptor 0.0057 0.0066 0.0066
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0066 0.0039
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0015 0.2428
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0023 0.1786
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0005 0.0005
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.0066 0.0066
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0061 0.3598
Schistosoma mansoni biogenic amine receptor 0.0057 0.0066 0.0066
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0066 0.0066
Schistosoma mansoni cpg binding protein 0.0028 0.0028 0.0028
Brugia malayi G-protein coupled receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0066 0.0066
Loa Loa (eye worm) glutathione reductase 0.0054 0.0061 0.0061
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0066 0.0066
Echinococcus multilocularis serotonin receptor 0.0057 0.0066 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.0521 0.0521
Loa Loa (eye worm) glutamate receptor 0.0017 0.0013 0.0013
Schistosoma mansoni opsin-like receptor 0.0057 0.0066 0.0066
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Brugia malayi AKH receptor 0.0057 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0403 0.0521 0.0521
Echinococcus granulosus serotonin receptor 0.0057 0.0066 0.0066
Toxoplasma gondii thioredoxin reductase 0.0054 0.0061 1
Onchocerca volvulus 0.0057 0.0066 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus neuropeptide receptor 0.0997 0.1303 0.1303
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0066 0.0066
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0015 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0066 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0066 0.0066
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0015 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0066 0.0066
Onchocerca volvulus 0.0057 0.0066 0.0039
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0152 0.8939
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0066 0.0066
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0005
Schistosoma mansoni biogenic amine receptor 0.0057 0.0066 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0015 0.0038
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0152 0.8939
Echinococcus granulosus allatostatin A receptor 0.0057 0.0066 0.0066
Plasmodium falciparum thioredoxin reductase 0.0054 0.0061 1
Plasmodium falciparum thioredoxin reductase 0.0019 0.0015 0.0038
Brugia malayi Dopamine receptor protein 1 0.0057 0.0066 0.0066
Brugia malayi G-protein coupled receptor 0.0057 0.0066 0.0066
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0023 0.1352
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Schistosoma mansoni ap endonuclease 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis serotonin receptor 0.0057 0.0066 0.0066
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.2428
Brugia malayi G protein-coupled receptor 0.0057 0.0066 0.0066
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0015 0.2428
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0066 0.0066
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0066 0.0066
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0023 0.1786
Brugia malayi hypothetical protein 0.0057 0.0066 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0066 0.0066
Plasmodium falciparum glutathione reductase 0.0019 0.0015 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0066 0.0066

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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