Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.012 | 0.1545 | 0.1502 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.04 | 0.0577 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0018 | 0.0051 | 0.0007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.0281 | 0.0394 |
Brugia malayi | RNA binding protein | 0.0266 | 0.3651 | 0.5988 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.3651 | 0.3643 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0079 | 0.0028 |
Onchocerca volvulus | 0.0061 | 0.0688 | 0.0888 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0074 | 0.0874 | 0.0827 |
Leishmania major | cathepsin L-like protease | 0.0074 | 0.0874 | 0.0827 |
Leishmania major | cathepsin L-like protease | 0.0074 | 0.0874 | 0.0827 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0052 | 0.0555 | 0.0849 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.042 | 0.0625 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.042 | 0.0371 |
Brugia malayi | intermediate filament protein | 0.0061 | 0.0688 | 0.1069 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0079 | 0.0028 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0079 | 0.0036 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.0059 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.0079 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0333 | 0.4625 | 0.4598 |
Loa Loa (eye worm) | TAR-binding protein | 0.0266 | 0.3651 | 0.5988 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.042 | 0.7161 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0058 | 0.0643 | 0.0595 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.0059 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0296 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.0846 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0052 | 0.0555 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0061 | 0.0688 | 0.1069 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.003 | 0.0227 | 0.0184 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0052 | 0.0555 | 0.0507 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0042 | 0.0401 | 0.0352 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0061 | 0.0688 | 0.1069 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0052 | 0.0555 | 0.0507 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.025 | 0.036 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.003 | 0.0227 | 0.0184 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.097 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.5451 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1276 | 0.2045 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.042 | 0.038 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 0.0874 | 0.0827 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.0079 | 0.0036 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0699 | 0.9946 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0062 | 0.0696 | 0.0658 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.042 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0025 | 0.0155 | 0.0105 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0079 | 0.0036 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.025 | 0.343 | 0.5621 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0052 | 0.0555 | 0.0517 |
Onchocerca volvulus | 0.0061 | 0.0688 | 0.0888 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Schistosoma mansoni | intermediate filament proteins | 0.0061 | 0.0688 | 0.065 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0079 | 0.0028 |
Schistosoma mansoni | rotamase | 0.0033 | 0.0281 | 0.024 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0296 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0019 | 0.0079 | 0.0028 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0296 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0052 | 0.0555 | 0.0517 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.0281 | 0.0406 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0033 | 0.027 | 0.022 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Schistosoma mansoni | lamin | 0.0061 | 0.0688 | 0.065 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.042 | 0.038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0022 | 0.0112 | 0.0061 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.0274 | 0.0382 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0051 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.021 | 0.0276 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0068 | 0.078 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0227 | 0.0303 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.3651 | 0.3643 |
Onchocerca volvulus | 0.0062 | 0.0696 | 0.09 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Brugia malayi | TAR-binding protein | 0.0266 | 0.3651 | 0.5988 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0245 | 0.0354 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0289 | 0.0417 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0052 | 0.0555 | 0.0517 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.042 | 0.0606 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0079 | 0.0036 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Brugia malayi | MH2 domain containing protein | 0.025 | 0.343 | 0.5621 |
Leishmania major | cathepsin L-like protease | 0.0074 | 0.0874 | 0.0827 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.0281 | 0.024 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 0.0874 | 0.0827 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0051 | 0.0073 |
Onchocerca volvulus | 0.0102 | 0.1276 | 0.1745 | |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.0059 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0079 | 0.0036 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.0079 | 0.5 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.027 | 0.0389 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0079 | 0.0036 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0297 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.0786 |
Giardia lamblia | GTOR | 0.0052 | 0.0555 | 0.5 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0042 | 0.0401 | 0.0352 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.3651 | 0.3643 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.0079 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.042 | 0.038 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.042 | 0.0371 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0051 | 0.0073 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.027 | 0.022 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.025 | 0.036 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.0846 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0051 | 0.0073 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.0059 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.0079 | 0.0059 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0062 | 0.0696 | 0.0658 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.0059 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.042 | 0.0606 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0555 | 0.0801 |
Echinococcus multilocularis | lamin dm0 | 0.0061 | 0.0688 | 0.065 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Echinococcus granulosus | tumor protein p63 | 0.0696 | 0.9902 | 0.9956 |
Trichomonas vaginalis | set domain proteins, putative | 0.0492 | 0.6934 | 1 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0079 | 0.0028 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.025 | 0.343 | 0.5621 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.04 | 0.0577 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0281 | 0.0406 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.042 | 0.0606 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0444 | 0.0641 |
Toxoplasma gondii | hypothetical protein | 0.0113 | 0.1442 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.04 | 0.0577 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0033 | 0.027 | 0.4002 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0051 | 0.0012 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0696 | 0.0658 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0062 | 0.0696 | 0.4525 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.025 | 0.036 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 0.0874 | 0.0827 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0671 | 0.1042 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0052 | 0.0555 | 0.0507 |
Plasmodium vivax | SET domain protein, putative | 0.0062 | 0.0696 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.0786 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.0079 | 0.0036 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Brugia malayi | Inositol-1 | 0.0043 | 0.042 | 0.0625 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0699 | 0.9946 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0297 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0297 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0245 | 0.0354 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0306 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0688 | 0.1069 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0052 | 0.0555 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0061 | 0.0688 | 0.065 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0555 | 0.0801 |
Loa Loa (eye worm) | intermediate filament protein | 0.0061 | 0.0688 | 0.1069 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0333 | 0.4625 | 0.4598 |
Echinococcus granulosus | expressed protein | 0.0033 | 0.0281 | 0.024 |
Echinococcus granulosus | tar DNA binding protein | 0.0266 | 0.3651 | 0.3643 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0079 | 0.0059 |
Brugia malayi | Pre-SET motif family protein | 0.0062 | 0.0696 | 0.1082 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.04 | 0.0577 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.04 | 0.0577 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0033 | 0.027 | 0.022 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0555 | 0.0801 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0042 | 0.0401 | 0.0352 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Schistosoma mansoni | lamin | 0.0061 | 0.0688 | 0.065 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.0079 | 0.0059 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0039 | 0.0361 | 0.2067 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0102 | 0.1276 | 0.1244 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0079 | 0.0059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0033 | 0.027 | 0.1399 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.042 | 0.2503 |
Brugia malayi | Pre-SET motif family protein | 0.0432 | 0.6068 | 1 |
Brugia malayi | hypothetical protein | 0.0355 | 0.4949 | 0.8142 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.0079 | 0.0036 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0079 | 0.0036 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.0079 | 0.0036 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.027 | 0.022 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0099 | 0.1231 | 0.1186 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0033 | 0.0274 | 0.0382 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0696 | 0.0658 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.0079 | 0.0059 |
Echinococcus granulosus | lamin | 0.0061 | 0.0688 | 0.065 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.0822 | 0.0775 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.0079 | 0.0059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0052 | 0.0555 | 0.0507 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0266 | 0.3651 | 0.5988 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0099 | 0.1231 | 0.1186 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.0079 | 0.0036 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0822 | 0.0786 |
Onchocerca volvulus | 0.0355 | 0.4949 | 0.7104 | |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.4949 | 0.8142 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0333 | 0.4625 | 0.4598 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0822 | 0.0846 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.042 | 0.038 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.0079 | 0.0059 |
Echinococcus granulosus | intermediate filament protein | 0.0061 | 0.0688 | 0.065 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0699 | 0.9946 | 1 |
Echinococcus multilocularis | lamin | 0.0061 | 0.0688 | 0.065 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0266 | 0.3651 | 0.5988 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.037 | 0.5171 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0099 | 0.1231 | 0.1186 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0052 | 0.0555 | 0.0507 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 0.0874 | 0.0827 |
Echinococcus multilocularis | tumor protein p63 | 0.0696 | 0.9902 | 0.9956 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.0281 | 0.0394 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.042 | 0.0371 |
Echinococcus multilocularis | tar DNA binding protein | 0.0266 | 0.3651 | 0.3643 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.3651 | 0.3643 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0822 | 0.0786 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0.0355 | 0.5 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0052 | 0.0555 | 0.0849 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0051 | 0.0073 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0062 | 0.0696 | 0.0658 |
Leishmania major | cathepsin L-like protease | 0.0019 | 0.0079 | 0.0028 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0099 | 0.1231 | 0.1186 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.3651 | 0.3643 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0062 | 0.0696 | 0.0658 |
Echinococcus multilocularis | musashi | 0.0061 | 0.0688 | 0.065 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0051 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0206 | 0.0297 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0361 | 0.052 |
Mycobacterium ulcerans | hypothetical protein | 0.037 | 0.5171 | 1 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0051 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0696 | 0.1082 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.006 | 0.0663 | 0.0625 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.042 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.021 | 0.0276 |
Loa Loa (eye worm) | RNA binding protein | 0.0266 | 0.3651 | 0.5988 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0052 | 0.0555 | 0.0507 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.0079 | 0.0114 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0696 | 0.0658 |
Leishmania major | cysteine peptidase A (CPA) | 0.0019 | 0.0079 | 0.0028 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.0079 | 0.0059 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0432 | 0.6068 | 1 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0051 | 0.0007 |
Onchocerca volvulus | 0.0492 | 0.6934 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.12 uM | Growth inhibition of human MCF7 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.15 uM | Growth inhibition of human KB cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.15 uM | Growth inhibition of human A2780 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.16 uM | Growth inhibition of human ZR-75-1 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human A549 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human HOP62 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human COLO205 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human PC3 cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
GI50 (functional) | = 0.18 uM | Growth inhibition of human SiHa cells after 48 hrs by SRB assay | ChEMBL. | 20031423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.