Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.0015 | 0.006 |
Plasmodium falciparum | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.006 | 0.109 | 0.1109 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.2532 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0042 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0042 | 0.0027 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0248 | 0.024 |
Brugia malayi | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.006 | 0.109 | 0.4304 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1414 | 0.0376 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.006 | 0.109 | 0.6064 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.015 | 0.4327 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0042 | 0.0105 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0015 | 0.006 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0448 | 0.1721 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0359 | 0.1417 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.006 | 0.109 | 0.4304 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0308 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.1414 | 0.1443 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1414 | 0.0376 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.2532 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Brugia malayi | Fatty acid elongation protein 3 | 0.03 | 0.9708 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Brugia malayi | GNS1/SUR4 family protein | 0.006 | 0.109 | 0.1109 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.03 | 0.9708 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0042 | 0.0027 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0042 | 0.0149 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0448 | 0.1771 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0042 | 0.0149 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0248 | 0.0925 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0042 | 0.0165 |
Toxoplasma gondii | fatty acid elongase | 0.006 | 0.109 | 0.1109 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0219 | 0.6807 | 0.7006 |
Leishmania major | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.1788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.109 | 0.1109 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0042 | 0.0149 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0308 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1414 | 0.5583 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.006 | 0.109 | 0.6064 |
Loa Loa (eye worm) | ELO-9 protein | 0.006 | 0.109 | 0.1109 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Plasmodium vivax | elongation of very long chain fatty acids protein 3, putative | 0.006 | 0.109 | 0.1109 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0359 | 0.1365 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.006 | 0.109 | 0.1364 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1414 | 0.5557 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0042 | 0.0027 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0308 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0248 | 0.024 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.1414 | 0.0376 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0248 | 0.1313 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.015 | 0.4327 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0042 | 0.0027 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.006 | 0.109 | 0.1109 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1414 | 0.7891 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0806 | 0.0815 |
Plasmodium vivax | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.006 | 0.109 | 0.1109 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.03 | 0.9708 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.03 | 0.9708 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.03 | 0.9708 | 1 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.03 | 0.9708 | 1 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.006 | 0.109 | 0.6064 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.006 | 0.109 | 0.6064 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.03 | 0.9708 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0248 | 0.1313 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.03 | 0.9708 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.1414 | 0.0376 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.006 | 0.109 | 0.427 |
Onchocerca volvulus | 0.0249 | 0.7898 | 1 | |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.03 | 0.9708 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.006 | 0.109 | 0.1364 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.006 | 0.109 | 0.1109 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.2532 | 0.2597 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.006 | 0.109 | 0.427 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.006 | 0.109 | 0.6064 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.1193 | 0.1215 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0248 | 0.0979 |
Brugia malayi | fatty acid elongation protein 3 | 0.006 | 0.109 | 0.1109 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0042 | 0.0149 |
Leishmania major | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Leishmania major | fatty acid elongase, putative | 0.03 | 0.9708 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.006 | 0.109 | 0.1364 |
Onchocerca volvulus | 0.006 | 0.109 | 0.1364 | |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1414 | 0.1443 |
Onchocerca volvulus | 0.0031 | 0.0042 | 0.0034 | |
Onchocerca volvulus | 0.006 | 0.109 | 0.1364 | |
Brugia malayi | Pre-SET motif family protein | 0.0219 | 0.6807 | 0.7006 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.015 | 0.4327 | 0.5 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.03 | 0.9708 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30 % | Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate at 10 uM after 20 mins | ChEMBL. | 21788139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.