Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 0.6678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0408 | 0.0408 |
Echinococcus multilocularis | geminin | 0.0173 | 0.5918 | 0.5918 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0261 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0408 | 0.061 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0546 | 0.0546 |
Echinococcus granulosus | geminin | 0.0173 | 0.5918 | 0.5918 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.6678 | 1 |
Onchocerca volvulus | 0.0053 | 0.0408 | 0.5 | |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.007 | 0.1195 | 0.1059 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0546 | 0.5 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.1195 | 0.1059 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.1195 | 0.1059 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0546 | 0.0546 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0408 | 0.061 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0546 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0546 | 0.0546 |
Leishmania major | 0.0189 | 0.6678 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5918 | 0.8861 |
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.8331 | 0.8331 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0546 | 0.0818 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 0.0546 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5918 | 0.8861 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 0.6678 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0546 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 0.6678 | 0.6678 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.8331 | 0.8331 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 0.6678 | 0.6678 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 0.6678 | 0.6678 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0261 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.6678 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0189 | 0.6678 | 0.6678 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0546 | 0.0546 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0546 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 0.6678 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.007 | 0.1195 | 0.1059 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0546 | 0.0546 |
Toxoplasma gondii | fructose-bisphospatase I | 0.007 | 0.1195 | 0.1059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.