TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.74 | Formula: C15H17ClN3O4P
H donors: 3 H acceptors: 4 LogP: 1.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(Cn1c(nc2c1ccc(c2N)Cl)c1ccc(o1)P(=O)(O)O)C
InChi: 1S/C15H17ClN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22)
InChiKey: NLMLWNQVPDVGOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fructose-1,6-bisphosphatase 1	Starlite/ChEMBL	References
Rattus norvegicus	Fructose-1,6-bisphosphatase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania braziliensis	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma japonicum	ko:K03841 fructose-1,6-bisphosphatase I, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania infantum	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Neospora caninum	Fructose-1 6-biphosphatase, related	Get druggable targets OG5_127400	All targets in OG5_127400
Toxoplasma gondii	fructose-bisphospatase II	Get druggable targets OG5_127400	All targets in OG5_127400
Candida albicans	similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania donovani	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania major		Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma mansoni	fructose-16-bisphosphatase-related	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei gambiense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma congolense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania mexicana	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus granulosus	fructose 16 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	fructose-bisphospatase I	Fructose-1,6-bisphosphatase	363 aa	326 aa	31.3 %
Neospora caninum	fructose-1,6-bisphosphatase, putative	Fructose-1,6-bisphosphatase	363 aa	298 aa	32.5 %
Onchocerca volvulus	CES-1 homolog	Fructose-1,6-bisphosphatase	363 aa	319 aa	60.5 %
Toxoplasma gondii	fructose-bisphospatase I	fructose-1,6-bisphosphatase 1	338 aa	326 aa	31.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0038	0.0219	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0135	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0153	0.0133
Toxoplasma gondii	fructose-bisphospatase I	0.0141	0.1304	0.3246
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0219	0.2295
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0219	0.0598
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0299	0.0279
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0034	0.0177	0.0133
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0242	0.2379	0.6141
Echinococcus multilocularis	isocitrate dehydrogenase	0.0037	0.0211	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0169	0.0332
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0353	0.0664
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	1
Echinococcus multilocularis	Smad4	0.0034	0.0177	0.0133
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0232	0.2533
Echinococcus granulosus	zinc finger protein	0.0026	0.0096	0.0051
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0219	0.0199
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0113	0.0069
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0378	0.3813	0.38
Schistosoma mansoni	cpg binding protein	0.0126	0.1151	0.1133
Brugia malayi	MH2 domain containing protein	0.0034	0.0177	0.0316
Brugia malayi	beta-lactamase family protein	0.0038	0.0219	0.0401
Echinococcus multilocularis	chromobox protein 1	0.0076	0.0616	0.0574
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0629	0.1431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0299	0.0279
Echinococcus granulosus	GPCR family 2	0.0034	0.0179	0.0135
Brugia malayi	CXXC zinc finger family protein	0.0126	0.1151	0.224
Leishmania major		0.0378	0.3813	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0037	0.0211	0.0168
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0219	0.0199
Echinococcus multilocularis	tumor protein p63	0.0354	0.3564	0.3535
Loa Loa (eye worm)	MH2 domain-containing protein	0.0498	0.5081	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0037	0.0211	0.2143
Loa Loa (eye worm)	hypothetical protein	0.004	0.0238	0.0467
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0232	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0629	0.1238
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0037	0.0211	0.0168
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0232	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0266	0.0808
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0179	0.0135
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0037	0.0211	0.2143
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0177	0.0348
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0232	0.0656
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0232	0.2533
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0034	0.0177	0.0133
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0299	0.0589
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.035	0.0307
Loa Loa (eye worm)	heterochromatin protein 1	0.0076	0.0616	0.1213
Onchocerca volvulus		0.0044	0.0284	0.0546
Schistosoma mansoni	hypothetical protein	0.0034	0.0179	0.0159
Brugia malayi	Probable ClpP-like protease	0.0077	0.0629	0.1209
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0041	0.0251	0.0741
Schistosoma mansoni	smad	0.0034	0.0177	0.0156
Echinococcus granulosus	cpg binding protein	0.0135	0.1247	0.1208
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0041	0.0251	0.0741
Schistosoma mansoni	Smad4	0.0034	0.0177	0.0156
Leishmania major	hypothetical protein, conserved	0.0038	0.0219	0.0022
Onchocerca volvulus		0.0126	0.1151	0.4661
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0219	0.0037
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0029	0.0126	0.0082
Schistosoma mansoni	chromobox protein	0.0076	0.0616	0.0597
Brugia malayi	Bromodomain containing protein	0.008	0.0666	0.1283
Brugia malayi	Isocitrate dehydrogenase	0.0037	0.0211	0.0385
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0232	0.0057
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0219	0.0598
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0065	0.0509	0.0466
Brugia malayi	MH1 domain containing protein	0.0034	0.0177	0.0316
Echinococcus granulosus	tumor protein p63	0.0354	0.3564	0.3535
Toxoplasma gondii	isocitrate dehydrogenase	0.0037	0.0211	0.0307
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.035	0.0637
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	1
Echinococcus multilocularis	dnaJ subfamily B	0.0963	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0179	0.0135
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0232	0.0308
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0378	0.3813	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0037	0.0211	0.0168
Brugia malayi	F/Y-rich N-terminus family protein	0.0041	0.0256	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0248	0.2439	0.4801
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0299	0.062
Schistosoma mansoni	cpg binding protein	0.0135	0.1247	0.1229
Echinococcus granulosus	chromobox protein 1	0.0076	0.0616	0.0574
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0034	0.0177	0.0156
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0243	0.2382	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0188	0.0144
Schistosoma mansoni	hypothetical protein	0.0034	0.0179	0.0159
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0219	0.0037
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0032	0.0161	0.014
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0029	0.0126	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0213	0.0419
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0378	0.3813	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0333	0.0656
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0219	0.0037
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0219	0.0037
Schistosoma mansoni	zinc finger protein	0.0026	0.0096	0.0075
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0219	0.0037
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0232	0.2533
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0219	0.0022
Loa Loa (eye worm)	Smad1	0.0034	0.0177	0.0348
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0177	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0598	0.1177
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0329	0.0286
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.0959	0.1887
Schistosoma mansoni	hypothetical protein	0.0034	0.0179	0.0159
Echinococcus multilocularis	chromobox protein 1	0.0076	0.0616	0.0574
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.0959	0.1861
Toxoplasma gondii	fructose-bisphospatase II	0.0378	0.3813	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0041	0.0251	0.0741
Schistosoma mansoni	bromodomain containing protein	0.0069	0.0546	0.0526
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0031	0.006
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0629	0.1431
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0219	0.0598
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	0.5
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0232	0.5
Echinococcus multilocularis	smad	0.0034	0.0177	0.0133
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0299	0.0964
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0041	0.0251	0.0741
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0299	0.0256
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0179	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0111	0.0101
Schistosoma mansoni	hypothetical protein	0.0051	0.0353	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0266	0.0523
Brugia malayi	Pre-SET motif family protein	0.0032	0.0153	0.027
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0021	0.0044	0.0024
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.035	0.0637
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0044	0.0284	0.0264
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0329	0.0309
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0135	0.0211
Onchocerca volvulus		0.0038	0.0219	0.024
Schistosoma mansoni	ap endonuclease	0.0039	0.0232	0.0212
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0598	0.1148
Brugia malayi	Bromodomain containing protein	0.0037	0.0212	0.0387
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0219	0.0037
Brugia malayi	fructose-1,6-bisphosphatase	0.0378	0.3813	0.7495
Brugia malayi	Pre-SET motif family protein	0.0205	0.1981	0.3879
Echinococcus multilocularis	survival motor neuron protein 1	0.0248	0.2439	0.2406
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0219	0.0037
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0177	0.0156
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0219	0.2295
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0232	0.0656
Loa Loa (eye worm)	transcription factor SMAD2	0.0498	0.5081	1
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.0616	0.2412
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0177	0.0156
Brugia malayi	isocitrate dehydrogenase	0.0037	0.0211	0.0385
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0629	0.0587
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0378	0.3813	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0219	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0219	0.0432
Brugia malayi	beta-lactamase family protein	0.0038	0.0219	0.0401
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0219	0.0022
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0219	0.0037
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0219	0.0037
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0219	0.2295
Brugia malayi	Heterochromatin protein 1	0.0076	0.0616	0.1184
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.004	0.0242	0.0198
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0851	0.8807	0.8801
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0219	0.0432
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0329	0.0286
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0065	0.0509	0.0466
Echinococcus granulosus	fetal alzheimer antigen falz	0.0029	0.0126	0.0082
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0041	0.0251	0.0741
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0141	0.1304	0.3033
Echinococcus multilocularis	cpg binding protein	0.0135	0.1247	0.1208
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0179	0.0135
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0299	0.0558
Brugia malayi	Smad1	0.0034	0.0177	0.0316
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.1981	0.3899
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0041	0.0251	0.0741
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.004	0.0242	0.0198
Loa Loa (eye worm)	histone methyltransferase	0.004	0.0242	0.0476
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0028	0.0111	0.0101
Onchocerca volvulus		0.0052	0.0366	0.0937
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0629	0.0587
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0366	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0219	0.0432
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0299	0.0256
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0032	0.0161	0.0117
Echinococcus granulosus	chromobox protein 1	0.0076	0.0616	0.0574
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.0616	0.2412
Schistosoma mansoni	ap endonuclease	0.0039	0.0232	0.0212
Brugia malayi	beta-lactamase	0.0038	0.0219	0.0401
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0219	0.0176
Onchocerca volvulus		0.0233	0.2276	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0032	0.0161	0.0117
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Echinococcus granulosus	Smad4	0.0034	0.0177	0.0133
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0219	0.0022
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0141	0.1304	0.3033
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0266	0.0808
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0232	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0179	0.0352
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0219	0.0176
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0299	0.0256
Loa Loa (eye worm)	nuclear factor I	0.0019	0.0016	0.0032
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0232	0.0057
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0269	0.2657	0.2642
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0179	0.0321
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0037	0.0211	0.0416
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0032	0.0161	0.0117
Schistosoma mansoni	hypothetical protein	0.0963	1	1
Brugia malayi	chromobox protein homolog 3	0.0042	0.0266	0.0492
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0179	0.0352
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0219	0.0432
Brugia malayi	hypothetical protein	0.0248	0.2439	0.4784
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.0299	0.0964
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0041	0.0251	0.0741
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0141	0.1304	0.3033
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0232	0.0457
Loa Loa (eye worm)	CHromoDomain protein family member	0.0021	0.0044	0.0087
Schistosoma mansoni	hypothetical protein	0.0034	0.0179	0.0159
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0179	0.0321
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0378	0.3813	0.7504
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0299	0.0256
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0219	0.0432
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0232	0.5
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0232	0.0189
Brugia malayi	MH2 domain containing protein	0.0034	0.0177	0.0316
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.035	0.4744
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0219	0.0432
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0037	0.0211	0.0168
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0378	0.3813	0.3785
Echinococcus granulosus	survival motor neuron protein 1	0.0248	0.2439	0.2406
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0629	1
Toxoplasma gondii	exonuclease III APE	0.0039	0.0232	0.0362
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	0.5
Schistosoma mansoni	hypothetical protein	0.002	0.0031	0.001
Trichomonas vaginalis	esterase, putative	0.0038	0.0219	0.0598
Toxoplasma gondii	isocitrate dehydrogenase	0.0037	0.0211	0.0307
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0219	0.0037
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0366	0.0347
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0177	0.0348
Toxoplasma gondii	ABC1 family protein	0.0038	0.0219	0.0328
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0378	0.3813	0.3785
Schistosoma mansoni	hypothetical protein	0.0074	0.0598	0.0579
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0188	0.0144
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.2276	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.012	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0219	0.0432
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.0959	0.1861
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0266	0.0459
Brugia malayi	PHD-finger family protein	0.0031	0.0151	0.0265
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0037	0.0211	0.0191
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0034	0.0177	0.0133
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0629	1
Brugia malayi	CHD4 protein	0.0021	0.0044	0.0055
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0629	0.061
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0141	0.1304	0.3246
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0041	0.0251	0.0741
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0032	0.0161	0.0117
Trichomonas vaginalis	helicase, putative	0.0029	0.012	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0329	0.0647
Schistosoma mansoni	chromobox protein	0.0076	0.0616	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0959	0.1887
Onchocerca volvulus		0.0051	0.0353	0.0873
Plasmodium vivax	SET domain protein, putative	0.0032	0.0153	0.105
Brugia malayi	MH2 domain containing protein	0.0498	0.5081	1
Echinococcus granulosus	smad	0.0034	0.0177	0.0133
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.035	0.0307
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0179	0.0135
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0329	0.0309
Echinococcus granulosus	mothers against decapentaplegic 5	0.0034	0.0177	0.0133
Schistosoma mansoni	cpg binding protein	0.0135	0.1247	0.1229
Brugia malayi	MH1 domain containing protein	0.0034	0.0177	0.0316
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0232	0.0057
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0126	0.1151	0.2265
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0153	0.0109
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0037	0.0211	0.0168
Onchocerca volvulus		0.0038	0.0219	0.024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0299	0.0279
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0353	0.0333
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0232	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0546	0.1075
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0219	0.0598
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0629	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0219	0.0401
Echinococcus multilocularis	zinc finger protein	0.0026	0.0096	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0219	0.0432
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0153	0.015

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.2 uM	Inhibition of human liver FBPase 1	ChEMBL.	20055427
IC50 (binding)	= 2 uM	Inhibition of rat liver FBPase 1	ChEMBL.	20055427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL583346

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1080460