TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.517 | Formula: C25H31NO5
H donors: 2 H acceptors: 4 LogP: 6.01 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCn1c2ccccc2c2c1cc(OCC(=O)O)c(c2)CCC(=O)O
InChi: 1S/C25H31NO5/c1-2-3-4-5-6-9-14-26-21-11-8-7-10-19(21)20-15-18(12-13-24(27)28)23(16-22(20)26)31-17-25(29)30/h7-8,10-11,15-16H,2-6,9,12-14,17H2,1H3,(H,27,28)(H,29,30)
InChiKey: ZVEJTPACEWXXBQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	cathepsin CPC2	0.0062	0.0085	0.0332
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0062	0.0085	0.0332
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Schistosoma mansoni	lamin	0.0173	0.0859	0.0859
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Onchocerca volvulus	Cathepsin L homolog	0.0337	0.2007	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0197	0.5
Loa Loa (eye worm)	hypothetical protein	0.0119	0.048	0.2048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Echinococcus multilocularis	cysteine protease	0.0337	0.2007	0.2007
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0119	0.048	0.048
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Loa Loa (eye worm)	cysteine protease	0.0337	0.2007	0.8561
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0059	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0119	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Giardia lamblia	Cathepsin L-like protease	0.0062	0.0085	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.1228	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Echinococcus granulosus	geminin	0.0387	0.2352	0.2352
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0107	0.0396	0.169
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0024	0.0101
Brugia malayi	jmjC domain containing protein	0.0071	0.0146	0.0624
Loa Loa (eye worm)	ctsf protein	0.0337	0.2007	0.8561
Giardia lamblia	Cysteine protease	0.0062	0.0085	1
Brugia malayi	Cathepsin L-like precursor	0.0112	0.0429	0.183
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0187	0.0959	0.4092
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0008	0.0008
Mycobacterium tuberculosis	Probable dehydrogenase	0.0122	0.0503	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0008	0.0008
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.0024	0.0019
Mycobacterium tuberculosis	Probable lipase LipD	0.0187	0.0959	0.1187
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0187	0.0959	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0187	0.0959	0.1187
Giardia lamblia	Encystation-specific protease	0.0062	0.0085	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0187	0.0959	0.1187
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0062	0.0085	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Brugia malayi	Cathepsin L-like precursor	0.0337	0.2007	0.8561
Echinococcus multilocularis	cathepsin L cysteine protease	0.0337	0.2007	0.2007
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0062	0.0085	0.0085
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0122	0.0503	0.0617
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0136	0.0598	0.0736
Brugia malayi	Cathepsin L-like precursor	0.0337	0.2007	0.8561
Trichomonas vaginalis	penicillin-binding protein, putative	0.0187	0.0959	0.4549
Giardia lamblia	Cathepsin L precursor	0.0062	0.0085	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0233	0.0995
Brugia malayi	Papain family cysteine protease containing protein	0.0337	0.2007	0.8561
Loa Loa (eye worm)	hypothetical protein	0.0376	0.2274	0.9701
Echinococcus multilocularis	lamin dm0	0.0173	0.0859	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.0085	0.0361
Plasmodium vivax	vivapain-3	0.0174	0.0864	0.4251
Toxoplasma gondii	cathepsin CPL	0.0337	0.2007	1
Onchocerca volvulus		0.0187	0.0959	0.4619
Brugia malayi	beta-lactamase	0.0187	0.0959	0.4092
Entamoeba histolytica	hypothetical protein	0.0107	0.0396	0.162
Schistosoma mansoni	hypothetical protein	0.0119	0.048	0.048
Entamoeba histolytica	cysteine proteinase, putative	0.0337	0.2007	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0008	0.0008
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1197	0.8016	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.006	0.0256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0062	0.0085	0.0085
Plasmodium vivax	unspecified product	0.0062	0.0085	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0959	0.4092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0864	0.4054
Onchocerca volvulus		0.0337	0.2007	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0062	0.0085	0.0332
Brugia malayi	PHD-finger family protein	0.0059	0.006	0.0256
Trypanosoma cruzi	cruzipain precursor, putative	0.0112	0.0429	0.0497
Giardia lamblia	Cathepsin L precursor	0.0062	0.0085	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0187	0.0959	0.4549
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0062	0.0085	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0777	0.3314
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0019	0.008
Leishmania major	cathepsin L-like protease	0.0337	0.2007	0.2325
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.0864	0.3686
Leishmania major	cathepsin L-like protease	0.1285	0.8631	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0187	0.0959	0.0959
Loa Loa (eye worm)	fibroinase	0.0337	0.2007	0.8561
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Plasmodium falciparum	serine repeat antigen 9	0.0062	0.0085	0.0332
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0119	0.048	0.048
Trypanosoma cruzi	major cysteine proteinase, putative	0.0062	0.0085	0.0098
Brugia malayi	Cathepsin L-like precursor	0.0226	0.1228	0.5237
Loa Loa (eye worm)	hypothetical protein	0.0337	0.2007	0.8561
Plasmodium vivax	vivapain-1	0.0174	0.0864	0.4251
Leishmania major	hypothetical protein, conserved	0.0053	0.0019	0.0022
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0085	0.0361
Trypanosoma cruzi	hypothetical protein, conserved	0.0187	0.0959	0.1111
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0429	0.183
Echinococcus granulosus	FTZ F1 alpha	0.0442	0.2738	0.2738
Plasmodium falciparum	serine repeat antigen 3	0.0062	0.0085	0.0332
Schistosoma mansoni	cathepsin B (C01 family)	0.0062	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Echinococcus multilocularis	cathepsin L	0.0174	0.0864	0.0864
Toxoplasma gondii	cathepsin CPC1	0.0062	0.0085	0.0332
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0337	0.2007	1
Plasmodium falciparum	serine repeat antigen 5	0.0062	0.0085	0.0332
Mycobacterium tuberculosis	Probable oxidoreductase	0.0136	0.0598	0.0736
Giardia lamblia	Hypothetical protein	0.0062	0.0085	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0187	0.0959	0.4092
Brugia malayi	latrophilin 2 splice variant baaae	0.0257	0.1444	0.6159
Leishmania major	trypanothione reductase	0.0053	0.0024	0.0027
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0376	0.2274	0.9701
Mycobacterium ulcerans	beta-lactamase	0.0187	0.0959	1
Brugia malayi	Probable ClpP-like protease	0.0078	0.0197	0.0841
Echinococcus multilocularis	musashi	0.0173	0.0859	0.0859
Schistosoma mansoni	hypothetical protein	0.0119	0.048	0.048
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0019	0.0022
Mycobacterium ulcerans	hypothetical protein	0.0187	0.0959	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0008	0.0008
Echinococcus granulosus	cathepsin b	0.0062	0.0085	0.0085
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.0864	0.0864
Loa Loa (eye worm)	jmjC domain-containing protein	0.0121	0.0497	0.2119
Schistosoma mansoni	hypothetical protein	0.0387	0.2352	0.2352
Trypanosoma brucei	hypothetical protein, conserved	0.0187	0.0959	0.1111
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0093	0.0297	0.1269
Plasmodium vivax	vivapain-2	0.0337	0.2007	1
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Onchocerca volvulus	Cathepsin F homolog	0.0337	0.2007	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0122	0.0503	0.0617
Loa Loa (eye worm)	PHD-finger family protein	0.0059	0.006	0.0256
Echinococcus multilocularis	peregrin	0.0059	0.006	0.006
Echinococcus granulosus	peregrin	0.0059	0.006	0.006
Trichomonas vaginalis	D-aminoacylase, putative	0.0187	0.0959	0.4549
Loa Loa (eye worm)	hypothetical protein	0.008	0.0211	0.0901
Schistosoma mansoni	cellular tumor antigen P53	0.0161	0.0777	0.0777
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Schistosoma mansoni	cathepsin s	0.0112	0.0429	0.0429
Brugia malayi	fibroinase precursor	0.0062	0.0085	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0226	0.1228	0.5237
Onchocerca volvulus		0.0337	0.2007	1
Brugia malayi	MH2 domain containing protein	0.0386	0.2344	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0192	0.0993	0.0993
Toxoplasma gondii	PHD-finger domain-containing protein	0.0059	0.006	0.0207
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0008	0.0032
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0062	0.0085	0.0332
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0024	0.0024
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0009	0.0009
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0062	0.0085	0.0332
Brugia malayi	cytoplasmic intermediate filament protein	0.0093	0.0297	0.1269
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0174	0.0864	0.4251
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Loa Loa (eye worm)	cathepsin B	0.0062	0.0085	0.0361
Onchocerca volvulus		0.0161	0.0777	0.3683
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0122	0.0503	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0226	0.1228	0.5237
Schistosoma mansoni	microtubule-associated protein tau	0.1481	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0174	0.0864	0.1001
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Trypanosoma cruzi	cysteine peptidase, putative	0.1285	0.8631	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0673	0.2872
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0197	0.0841
Echinococcus multilocularis	cysteine protease	0.0337	0.2007	0.2007
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.0864	0.4054
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0107	0.0396	0.0396
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0024	0.0024
Trichomonas vaginalis	penicillin-binding protein, putative	0.0187	0.0959	0.4549
Mycobacterium tuberculosis	Conserved protein	0.0187	0.0959	0.1187
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0353	0.1506
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0024	0.0024
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0136	0.0598	0.0736
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0197	0.1984
Leishmania major	cathepsin L-like protease	0.1285	0.8631	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.0864	0.0864
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0197	0.0897
Echinococcus granulosus	cathepsin b	0.0062	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Echinococcus granulosus	lamin	0.0173	0.0859	0.0859
Mycobacterium tuberculosis	Probable hydrolase	0.0187	0.0959	0.1187
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0337	0.2007	0.2007
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.0864	0.3686
Echinococcus granulosus	tumor protein p63	0.1102	0.7351	0.7351
Echinococcus multilocularis	lamin	0.0173	0.0859	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0959	0.4092
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0062	0.0085	0.0332
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0008	0.0008
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0959	0.4092
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Echinococcus multilocularis	geminin	0.0387	0.2352	0.2352
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0024	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Plasmodium falciparum	phd finger protein, putative	0.0059	0.006	0.0207
Onchocerca volvulus		0.0187	0.0959	0.4619
Mycobacterium ulcerans	esterase/lipase LipP	0.0187	0.0959	1
Brugia malayi	Latrophilin receptor protein 2	0.0119	0.048	0.2048
Onchocerca volvulus		0.0337	0.2007	1
Onchocerca volvulus		0.0337	0.2007	1
Leishmania major	cysteine peptidase A (CPA)	0.0337	0.2007	0.2325
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0146	0.0146
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0053	0.0019	0.008
Entamoeba histolytica	hypothetical protein	0.0107	0.0396	0.162
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0062	0.0085	0.0085
Echinococcus granulosus	cathepsin l1	0.0226	0.1228	0.1228
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0429	0.183
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0119	0.048	0.048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Echinococcus multilocularis	cathepsin L	0.0062	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.008	0.0211	0.0901
Schistosoma mansoni	hypothetical protein	0.0387	0.2352	0.2352
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0192	0.0993	0.0993
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0226	0.1228	0.5237
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0376	0.2274	0.9701
Loa Loa (eye worm)	transcription factor SMAD2	0.0386	0.2344	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.1228	0.5237
Leishmania major	cathepsin L-like protease	0.0337	0.2007	0.2325
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Schistosoma mansoni	lamin	0.0173	0.0859	0.0859
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0062	0.0085	0.0332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.0085	0.0361
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0429	0.0497
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0062	0.0085	0.0098
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0024	0.0101
Giardia lamblia	Cathepsin L precursor	0.0062	0.0085	1
Plasmodium vivax	hypothetical protein, conserved	0.0059	0.006	0.0207
Onchocerca volvulus	Cathepsin L homolog	0.0337	0.2007	1
Leishmania major	hypothetical protein, conserved	0.0187	0.0959	0.1111
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Mycobacterium leprae	conserved hypothetical protein	0.0187	0.0959	1
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0085	0.0361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Trichomonas vaginalis	esterase, putative	0.0187	0.0959	0.4549
Brugia malayi	jmjC domain containing protein	0.0192	0.0993	0.4237
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Entamoeba histolytica	hypothetical protein	0.0107	0.0396	0.162
Trypanosoma cruzi	hypothetical protein, conserved	0.0187	0.0959	0.1111
Toxoplasma gondii	ABC1 family protein	0.0187	0.0959	0.473
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Mycobacterium leprae	Probable lipase LipE	0.0187	0.0959	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0062	0.0085	0.0332
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0119	0.048	0.2048
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0429	0.183
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0337	0.2007	0.8561
Leishmania major	cathepsin L-like protease	0.0337	0.2007	0.2325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0337	0.2007	0.2007
Loa Loa (eye worm)	intermediate filament protein	0.0173	0.0859	0.3664
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0062	0.0085	0.0098
Giardia lamblia	Cysteine protease	0.0062	0.0085	1
Brugia malayi	hypothetical protein	0.0146	0.0673	0.2872
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0173	0.0859	0.3664
Giardia lamblia	Cathepsin L precursor	0.0062	0.0085	1
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.0864	0.4054
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0197	0.0197
Toxoplasma gondii	PHD-finger domain-containing protein	0.0059	0.006	0.0207
Plasmodium vivax	serine-repeat antigen (SERA)	0.0062	0.0085	0.0332
Schistosoma mansoni	transcription factor LCR-F1	0.0107	0.0396	0.0396
Mycobacterium tuberculosis	Probable lipase LipE	0.0187	0.0959	0.1187
Brugia malayi	cathepsin F-like cysteine proteinase	0.0112	0.0429	0.183
Plasmodium vivax	unspecified product	0.0174	0.0864	0.4251
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0337	0.2007	0.2007
Echinococcus multilocularis	cathepsin b	0.0062	0.0085	0.0085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0959	0.4092
Onchocerca volvulus		0.0187	0.0959	0.4619
Plasmodium falciparum	serine repeat antigen 6	0.0062	0.0085	0.0332
Trypanosoma cruzi	cysteine proteinase, putative	0.0174	0.0864	0.1001
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0197	0.5
Plasmodium falciparum	glutathione reductase	0.0053	0.0024	0.0024
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0257	0.1444	0.6159
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0122	0.0503	0.0617
Plasmodium falciparum	serine repeat antigen 8	0.0062	0.0085	0.0332
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0112	0.0429	0.183
Trypanosoma cruzi	cysteine peptidase, putative	0.0337	0.2007	0.2325
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0062	0.0085	0.0332
Entamoeba histolytica	cysteine proteinase, putative	0.0226	0.1228	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Giardia lamblia	Cysteine protease	0.0062	0.0085	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0337	0.2007	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0187	0.0959	0.1187
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0146	0.0146
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0337	0.2007	1
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.0864	0.4054
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0008	0.0008
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0337	0.2007	0.2007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0085	0.0085
Loa Loa (eye worm)	beta-lactamase	0.0187	0.0959	0.4092
Onchocerca volvulus		0.0226	0.1228	0.5998
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.0085	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0107	0.0396	0.0396
Schistosoma mansoni	hypothetical protein	0.0059	0.006	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Echinococcus multilocularis	microtubule associated protein 2	0.1481	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0174	0.0864	0.4054
Onchocerca volvulus		0.0337	0.2007	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0864	0.1001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0008	0.0008
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0019	0.0022
Giardia lamblia	Cathepsin L precursor	0.0062	0.0085	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.0019	0.0022
Giardia lamblia	Cysteine protease	0.0062	0.0085	1
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0062	0.0085	0.0361
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0062	0.0085	0.0332
Loa Loa (eye worm)	hypothetical protein	0.017	0.0837	0.3569
Trypanosoma cruzi	cruzipain precursor, putative	0.1285	0.8631	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0062	0.0085	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.0197	0.0897
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.0085	0.0361
Plasmodium vivax	vivapain-2	0.0337	0.2007	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0062	0.0085	0.0332
Brugia malayi	Cathepsin L-like precursor	0.0337	0.2007	0.8561
Giardia lamblia	Cathepsin L precursor	0.0062	0.0085	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0337	0.2007	1
Echinococcus granulosus	cathepsin L	0.0174	0.0864	0.0864
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0864	0.1001
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0187	0.0959	0.0959
Echinococcus granulosus	cathepsin L	0.0062	0.0085	0.0085
Mycobacterium tuberculosis	Conserved protein	0.0187	0.0959	0.1187
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0119	0.048	0.048
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0122	0.0503	0.5196
Echinococcus granulosus	intermediate filament protein	0.0173	0.0859	0.0859
Plasmodium falciparum	serine repeat antigen 7	0.0062	0.0085	0.0332
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.0085	0.0085
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.0864	0.4054
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0197	0.0197
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0062	0.0085	0.0098
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0062	0.0085	1
Plasmodium falciparum	serine repeat antigen 4	0.0062	0.0085	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0859	0.3664
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0062	0.0085	0.0085
Echinococcus multilocularis	tumor protein p63	0.1102	0.7351	0.7351
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0024	0.0024
Schistosoma mansoni	cathepsin F (C01 family)	0.0337	0.2007	0.2007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Brugia malayi	cathepsin L precursor	0.0062	0.0085	0.0361
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0062	0.0085	0.0332
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0083	0.0233	0.0233
Echinococcus multilocularis	jumonji domain containing protein	0.0082	0.0221	0.0221
Trypanosoma brucei	trypanothione reductase	0.0053	0.0024	0.0027
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1174	0.7852	0.9097
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0107	0.0396	0.0396
Brugia malayi	cathepsin L-like precursor	0.0226	0.1228	0.5237
Echinococcus multilocularis	cathepsin L cysteine protease	0.0337	0.2007	0.2007
Leishmania major	cathepsin L-like protease	0.1285	0.8631	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0174	0.0864	0.1001
Toxoplasma gondii	cathepsin B	0.0062	0.0085	0.0332
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0187	0.0959	0.0959
Echinococcus granulosus	jumonji domain containing protein	0.0082	0.0221	0.0221
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.0085	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Brugia malayi	Thioredoxin reductase	0.0053	0.0024	0.0101
Brugia malayi	cathepsin F-like cysteine proteinase	0.0062	0.0085	0.0361
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0337	0.2007	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0197	0.5
Onchocerca volvulus		0.0337	0.2007	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0337	0.2007	0.2007
Schistosoma mansoni	intermediate filament proteins	0.0173	0.0859	0.0859
Entamoeba histolytica	hypothetical protein	0.0107	0.0396	0.162
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0187	0.0959	0.0959
Schistosoma mansoni	jumonji domain containing protein	0.0153	0.0717	0.0717
Giardia lamblia	Cathepsin L-like protease	0.0062	0.0085	1
Mycobacterium tuberculosis	Conserved protein	0.0187	0.0959	0.1187
Brugia malayi	Bromodomain containing protein	0.0059	0.006	0.0256
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0024	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0864	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0146	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Brugia malayi	intermediate filament protein	0.0173	0.0859	0.3664
Trypanosoma cruzi	cysteine protease, putative	0.0174	0.0864	0.1001
Schistosoma mansoni	hypothetical protein	0.0257	0.1444	0.1444
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0187	0.0959	0.1187
Echinococcus granulosus	GPCR family 2	0.0119	0.048	0.048
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0197	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0008	0.0032
Echinococcus granulosus	lamin dm0	0.0173	0.0859	0.0859
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0959	0.4092
Brugia malayi	Cathepsin L-like precursor	0.0337	0.2007	0.8561
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.0864	0.1001
Brugia malayi	Cathepsin L-like precursor	0.0226	0.1228	0.5237
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.0197	0.0197
Onchocerca volvulus		0.0173	0.0859	0.4103
Echinococcus multilocularis	cathepsin b	0.0062	0.0085	0.0085
Plasmodium falciparum	serine repeat antigen 1	0.0062	0.0085	0.0332
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0376	0.2274	0.9701
Entamoeba histolytica	cysteine protease, putative	0.0337	0.2007	1
Onchocerca volvulus		0.0173	0.0859	0.4103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0226	0.1228	0.5946
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.0085	0.0361
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0062	0.0085	0.0332
Giardia lamblia	Hypothetical protein	0.0062	0.0085	1
Onchocerca volvulus		0.0337	0.2007	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0062	0.0085	0.0361
Plasmodium vivax	hypothetical protein, conserved	0.0187	0.0959	0.473
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0197	0.0897
Leishmania major	cathepsin L-like protease	0.0337	0.2007	0.2325
Brugia malayi	cathepsin L-like cysteine proteinase	0.0062	0.0085	0.0361
Schistosoma mansoni	cathepsin C	0.0062	0.0085	0.0085
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0136	0.0598	0.6197
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0337	0.2007	0.8561
Entamoeba histolytica	cysteine proteinase 2	0.0174	0.0864	0.4054
Trypanosoma cruzi	major cysteine proteinase, putative	0.101	0.6709	0.7773
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0062	0.0085	0.0332
Brugia malayi	Intermediate filament tail domain containing protein	0.0173	0.0859	0.3664
Leishmania major	cathepsin L-like protease	0.0337	0.2007	0.2325
Brugia malayi	cathepsin B-like cysteine proteinase	0.0062	0.0085	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0085	0.0361
Echinococcus granulosus	cysteine protease	0.0174	0.0864	0.0864
Plasmodium falciparum	serine repeat antigen 2	0.0062	0.0085	0.0332
Echinococcus granulosus	cathepsin L cysteine protease	0.0174	0.0864	0.0864
Loa Loa (eye worm)	MH2 domain-containing protein	0.0386	0.2344	1
Mycobacterium tuberculosis	Probable reductase	0.0122	0.0503	0.0617
Onchocerca volvulus	Cathepsin L homolog	0.0062	0.0085	0.0127
Brugia malayi	glutathione reductase	0.0053	0.0024	0.0101
Brugia malayi	beta-lactamase family protein	0.0187	0.0959	0.4092
Schistosoma mansoni	hypothetical protein	0.0119	0.048	0.048
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0119	0.048	0.2048
Echinococcus multilocularis	GPCR, family 2	0.0119	0.048	0.048
Echinococcus granulosus	cathepsin l1	0.0337	0.2007	0.2007
Echinococcus granulosus	PHD finger protein rhinoceros	0.0059	0.006	0.006
Trichomonas vaginalis	D-aminoacylase, putative	0.0187	0.0959	0.4549
Schistosoma mansoni	cathepsin F (C01 family)	0.0226	0.1228	0.1228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1285	0.8631	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1285	0.8631	1
Brugia malayi	beta-lactamase family protein	0.0187	0.0959	0.4092
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0337	0.2007	0.8561
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0174	0.0864	0.0864
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.0197	0.0897
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0062	0.0085	0.0098
Giardia lamblia	Cathepsin B precursor	0.0062	0.0085	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0059	0.006	0.006
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0864	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0337	0.2007	1
Brugia malayi	Cathepsin L-like precursor	0.0337	0.2007	0.8561
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0062	0.0085	0.0332
Onchocerca volvulus		0.0062	0.0085	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0959	0.4092
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0083	0.0233	0.0233
Onchocerca volvulus		0.0146	0.0673	0.315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0337	0.2007	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0062	0.0085	1
Entamoeba histolytica	cysteine proteinase, putative	0.0337	0.2007	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0112	0.0429	0.183
Trypanosoma cruzi	cysteine peptidase, putative	0.1285	0.8631	1
Plasmodium vivax	unspecified product	0.0112	0.0429	0.2063
Mycobacterium ulcerans	lipase LipD	0.0187	0.0959	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 80 uM	Modulation of gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in amyloid beta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay	ChEMBL.	21763147

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1812417

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1080603