Detailed information for compound 1081001

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 513.03 | Formula: C30H29ClN4O2
  • H donors: 0 H acceptors: 2 LogP: 5.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)n1cccc1CN1CCC(CC1)N1CC(OC1=O)(c1ccccc1)c1ccccn1
  • InChi: 1S/C30H29ClN4O2/c31-24-11-13-25(14-12-24)34-18-6-9-27(34)21-33-19-15-26(16-20-33)35-22-30(37-29(35)36,23-7-2-1-3-8-23)28-10-4-5-17-32-28/h1-14,17-18,26H,15-16,19-22H2
  • InChiKey: VNQUMICVOTUFIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0067 0.0384 0.077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.049 0.0448
Onchocerca volvulus 0.0061 0.0315 0.04
Mycobacterium ulcerans hypothetical protein 0.0076 0.049 1
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.049 1
Brugia malayi Pre-SET motif family protein 0.0423 0.4461 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0389 0.4073 0.4047
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0097 0.0104
Schistosoma mansoni hypothetical protein 0.0907 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0315 0.0272
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0115 0.0071
Toxoplasma gondii ABC1 family protein 0.0076 0.049 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0315 0.0272
Brugia malayi AMP-binding enzyme family protein 0.005 0.0193 0.0338
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.049 0.0947
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.049 0.0947
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0115 0.0071
Loa Loa (eye worm) hypothetical protein 0.005 0.0193 0.0338
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0193 0.3343
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0115 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.031 0.3166 0.707
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0139
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0193 0.3343
Echinococcus multilocularis geminin 0.0907 1 1
Onchocerca volvulus 0.0076 0.049 0.0749
Echinococcus granulosus tar DNA binding protein 0.0067 0.0384 0.0342
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1768 0.1731
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0116 0.0072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0389 0.4073 0.4047
Schistosoma mansoni patched 1 0.0043 0.0116 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0115 0.0071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0115 0.0071
Echinococcus granulosus GPCR family 2 0.005 0.0191 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0389 0.4073 0.4047
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.049 0.0877
Echinococcus multilocularis protein patched 0.0043 0.0116 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0115 0.0159
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0097 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0115 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0115 0.0159
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.4461 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0315 0.0272
Loa Loa (eye worm) hypothetical protein 0.0043 0.0116 0.0163
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0193 0.3945
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0384 0.0342
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0384 0.0342
Brugia malayi RNA binding protein 0.0067 0.0384 0.077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0049 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0193 0.3343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.049 0.0448
Schistosoma mansoni hypothetical protein 0.005 0.0191 0.0147
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0115 0.0071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0049 0.001
Schistosoma mansoni alpha-glucosidase 0.0161 0.1469 0.1431
Brugia malayi beta-lactamase 0.0076 0.049 0.101
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0191 0.0147
Brugia malayi nuclear hormone receptor 0.0043 0.0115 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0115 0.0159
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0097 0.0725
Schistosoma mansoni hypothetical protein 0.005 0.0191 0.0147
Brugia malayi hypothetical protein 0.0038 0.0055 0.0023
Schistosoma mansoni hypothetical protein 0.0108 0.0853 0.0812
Mycobacterium tuberculosis Conserved protein 0.0076 0.049 0.0947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0115 0.0159
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0115 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0115 0.0159
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0384 0.077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0191 0.0332
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0485 0.5176 1
Echinococcus multilocularis protein dispatched 1 0.0049 0.0186 0.0143
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0115 0.0071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0115 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.049 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0191 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0115 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0135 0.1162 0.253
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0116 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0384 0.0342
Loa Loa (eye worm) hypothetical protein 0.0053 0.0228 0.0415
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0384 0.0342
Mycobacterium tuberculosis Conserved protein 0.0076 0.049 0.0947
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0115 0.0159
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0116 0.0072
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0097 0.012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.1768 0.3903
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0054
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0775 0.1655
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0135 0.1162 0.1122
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0315 0.0272
Brugia malayi Pre-SET motif family protein 0.0061 0.0315 0.0613
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.049 0.0877
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0193 0.3343
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1768 0.1731
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0193 0.3343
Loa Loa (eye worm) hypothetical protein 0.005 0.0193 0.0338
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0097 0.0104
Loa Loa (eye worm) RNA binding protein 0.0067 0.0384 0.077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0115 0.0071
Loa Loa (eye worm) hypothetical protein 0.0076 0.049 0.101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0193 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0389 0.4073 0.9122
Brugia malayi beta-lactamase family protein 0.0076 0.049 0.101
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0115 0.0071
Mycobacterium ulcerans hypothetical protein 0.005 0.0193 0.3343
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0055 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.049 0.0877
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0793 0.0752
Loa Loa (eye worm) hypothetical protein 0.0076 0.049 0.101
Loa Loa (eye worm) hypothetical protein 0.005 0.0191 0.0332
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1271 0.1232
Schistosoma mansoni hypothetical protein 0.005 0.0191 0.0147
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0389 0.4073 0.9122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.029 0.0246
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0315 0.6071
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1271 0.1232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0115 0.0071
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0193 0.0149
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.0076 0.049 0.101
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0193 0.3945
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.8723 0.8717
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0139
Trypanosoma brucei glucosidase, putative 0.0042 0.0097 0.1188
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0097 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0115 0.0071
Loa Loa (eye worm) hypothetical protein 0.005 0.0193 0.0338
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0049
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0775 0.0734
Brugia malayi hypothetical protein 0.031 0.3166 0.707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0315 0.0272
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.049 0.0947
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0315 0.0272
Brugia malayi beta-lactamase family protein 0.0076 0.049 0.101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0135 0.1162 0.253
Onchocerca volvulus 0.0108 0.0863 0.1492
Echinococcus multilocularis tumor protein p63 0.0341 0.3526 0.3497
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0115 0.0071
Plasmodium vivax SET domain protein, putative 0.0061 0.0315 0.6032
Brugia malayi CHE-14 protein 0.0043 0.0116 0.0163
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0193 0.3343
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0115 0.0071
Schistosoma mansoni hypothetical protein 0.005 0.0191 0.0147
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.049 0.101
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0135 0.1162 0.1122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0049 0.001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0049 0.0094
Echinococcus granulosus expressed conserved protein 0.0095 0.0705 0.0664
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0115 0.0071
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0193 0.0374
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0055 0.001
Schistosoma mansoni hypothetical protein 0.0907 1 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0097 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0384 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0115 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0115 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0115 0.0159
Echinococcus multilocularis GPCR, family 2 0.005 0.0191 0.0147
Echinococcus granulosus tumor protein p63 0.0341 0.3526 0.3497
Plasmodium vivax hypothetical protein, conserved 0.0076 0.049 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.049 0.0947
Loa Loa (eye worm) hypothetical protein 0.005 0.0193 0.0336
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0139
Loa Loa (eye worm) hypothetical protein 0.0076 0.049 0.101
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0097 0.1188
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.1768 0.1731
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0135 0.1162 0.1122
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0193 0.3343
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0115 0.0071
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0115 0.0071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0384 0.077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0115 0.0071
Brugia malayi Latrophilin receptor protein 2 0.005 0.0191 0.0332
Echinococcus multilocularis expressed conserved protein 0.0095 0.0705 0.0664
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0097 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0097 0.1188
Loa Loa (eye worm) hypothetical protein 0.0076 0.049 0.101
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0853 0.1831
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.049 0.0448
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.049 0.0877
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.1423 0.3122
Onchocerca volvulus 0.0076 0.049 0.0749
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.049 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0115 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0049
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0193 0.2039
Mycobacterium ulcerans lipase LipD 0.0076 0.049 1
Brugia malayi nuclear receptor NHR-88 0.0043 0.0115 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0389 0.4073 0.4047
Brugia malayi ecdysteroid receptor 0.0043 0.0115 0.0159
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0115 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0049
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0193 0.2039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0191 0.0147
Mycobacterium ulcerans beta-lactamase 0.0076 0.049 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.1423 0.3122
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.049 0.0877
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0315 0.0272
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0115 0.0159
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0384 0.077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0389 0.4073 0.4047
Loa Loa (eye worm) hypothetical protein 0.0101 0.0775 0.1655
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0097 0.0104
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0115 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0116 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.0061 0.0315 0.0613
Loa Loa (eye worm) hypothetical protein 0.0135 0.1162 0.253
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0049 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0135 0.1162 0.1122
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.049 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0191 0.0332
Brugia malayi AMP-binding enzyme family protein 0.005 0.0193 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0097 0.1188
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0097 0.1188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0097 0.0725
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0049 0.0098
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0193 0.3343
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0097 0.0104
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0115 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0097 0.0104
Onchocerca volvulus 0.0481 0.5129 1
Loa Loa (eye worm) beta-lactamase 0.0076 0.049 0.101
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.049 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0115 0.0159
Onchocerca volvulus 0.0076 0.049 0.0749
Trichomonas vaginalis set domain proteins, putative 0.0481 0.5129 1
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0115 0.0071
Schistosoma mansoni alpha-glucosidase 0.0161 0.1469 0.1431
Loa Loa (eye worm) hypothetical protein 0.0157 0.1423 0.3122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0389 0.4073 0.4047
Schistosoma mansoni hypothetical protein 0.0038 0.0055 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0115 0.0159
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0775 0.0734
Schistosoma mansoni alpha glucosidase 0.0042 0.0097 0.0053
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0044 0.5
Onchocerca volvulus 0.005 0.0193 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0076 0.049 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.0108 0.0853 0.1831
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0049 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0115 0.0159
Schistosoma mansoni hypothetical protein 0.0091 0.0668 0.0626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0115 0.0159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0049 0.001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.049 0.0947
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0193 0.3343
Onchocerca volvulus 0.031 0.3166 0.6086
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.049 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.1423 0.3122
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0193 0.3343
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.049 0.101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0115 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0191 0.0147
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0116 0.0163
Echinococcus granulosus FTZ F1 alpha 0.0474 0.5044 0.5022
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.049 0.0448
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0389 0.4073 0.4047
Schistosoma mansoni coup transcription factor 0.0043 0.0115 0.0071
Schistosoma mansoni hypothetical protein 0.0042 0.0098 0.0054
Onchocerca volvulus 0.005 0.0193 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0384 0.0342
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0097 0.0104
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.049 0.101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0115 0.0159
Mycobacterium leprae Probable lipase LipE 0.0076 0.049 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0115 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0055 0.001
Mycobacterium tuberculosis Conserved protein 0.0076 0.049 0.0947
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0097 0.0104
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.1768 0.3903
Leishmania major hypothetical protein, conserved 0.0076 0.049 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.0193 0.0338
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0097 0.012
Trichomonas vaginalis esterase, putative 0.0076 0.049 0.0877
Loa Loa (eye worm) hypothetical protein 0.0037 0.0049 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.049 0.0947
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0193 0.2039
Brugia malayi steroid hormone receptor 0.0043 0.0115 0.0159

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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