Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0164 | 0.077 | 0.5 |
Brugia malayi | bHLH-PAS transcription factor | 0.0072 | 0.0195 | 0.1082 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0154 | 0.0707 | 0.0707 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0164 | 0.077 | 0.1072 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase I subunit F | 0.0164 | 0.077 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0097 | 0.0539 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0303 | 0.1646 | 0.9114 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1631 | 1 | 1 |
Schistosoma mansoni | single-minded | 0.0098 | 0.0356 | 0.4615 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0088 | 0.0292 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0097 | 0.0539 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.0707 | 0.9176 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0098 | 0.0356 | 0.4615 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0164 | 0.077 | 1 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0154 | 0.0707 | 0.0707 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0164 | 0.077 | 0.077 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0164 | 0.077 | 0.4266 |
Brugia malayi | PAS domain containing protein | 0.0098 | 0.0356 | 0.1969 |
Brugia malayi | hypothetical protein | 0.0328 | 0.1806 | 1 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0164 | 0.077 | 0.5 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0164 | 0.077 | 0.4266 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0164 | 0.077 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0164 | 0.077 | 0.077 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0097 | 0.0539 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0164 | 0.077 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.0195 | 0.6692 | |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0164 | 0.077 | 0.5 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0164 | 0.077 | 0.5 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0154 | 0.0707 | 0.8896 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0925 | 0.5557 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0072 | 0.0195 | 0.0195 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0097 | 0.0539 |
Mycobacterium ulcerans | proteasome PrcA | 0.1631 | 1 | 1 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0164 | 0.077 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0303 | 0.1646 | 0.9114 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0164 | 0.077 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.1806 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 76 uM | Inhibition of mitochondrial protein synthesis (MPS) in rat heart mitochondria | ChEMBL. | 12127518 |
IC50 (binding) | > 150 uM | Inhibition of Monoamine oxidase B in rat primary hepatocytes | ChEMBL. | 12127518 |
IC50 (binding) | > 150 uM | Inhibition of Monoamine oxidase B in rat primary hepatocytes | ChEMBL. | 12127518 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration measured against Streptococcus pneumoniae | ChEMBL. | 12127518 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration measured against S. epidermidis | ChEMBL. | 12127518 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration measured against E. faecium | ChEMBL. | 12127518 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration measured against S. aureus | ChEMBL. | 12127518 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration measured against Moraxella catarrhalis | ChEMBL. | 12127518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.