Detailed information for compound 1081156

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 309.341 | Formula: C13H15N3O4S
  • H donors: 3 H acceptors: 4 LogP: -1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](Cn1c(=O)[nH]c(=O)c2c1sc1c2CCCC1)N
  • InChi: 1S/C13H15N3O4S/c14-7(12(18)19)5-16-11-9(10(17)15-13(16)20)6-3-1-2-4-8(6)21-11/h7H,1-5,14H2,(H,18,19)(H,15,17,20)/t7-/m0/s1
  • InChiKey: XUGDTWLLDWSJQZ-ZETCQYMHSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate receptor ionotropic kainate 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis NMDA receptor Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum expressed protein Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum Glutamate receptor, ionotropic kainate 1 precursor, putative Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum expressed protein Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis glutamate receptor ionotropic kainate Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus glutamate receptor ionotropic kainate 3 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum Glutamate receptor, ionotropic kainate 3 precursor, putative Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma mansoni glutamate receptor kainate Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus glutamate receptor ionotropic kainate Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma mansoni glutamate receptor kainate Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum Glutamate receptor delta-2 subunit precursor, putative Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster Glutamate receptor IA Glutamate receptor ionotropic kainate 1   949 aa 913 aa 34.5 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis lysine specific demethylase 5A 0.0144 0.1536 0.1493
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.1848
Loa Loa (eye worm) hypothetical protein 0.0119 0.1226 0.2097
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0408
Echinococcus multilocularis dna polymerase kappa 0.0247 0.2827 0.279
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0039 0.023 0.0179
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0039 0.023 0.0179
Echinococcus granulosus dna polymerase eta 0.0473 0.5633 0.561
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0574 0.1881
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.038 0.0675
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0389 0.4585 0.4557
Brugia malayi hypothetical protein 0.0029 0.0106 0.0096
Mycobacterium ulcerans beta-lactamase 0.0107 0.1084 0.3483
Plasmodium falciparum pantothenate kinase 2, putative 0.0034 0.0167 0.0982
Mycobacterium ulcerans hypothetical protein 0.0107 0.1084 0.3483
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.016 0.0284
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0247 0.2827 1
Schistosoma mansoni pantothenate kinase 0.0079 0.0737 0.069
Brugia malayi hypothetical protein 0.0107 0.1078 0.1807
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0051 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.038 0.0852
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0119 0.1226 0.118
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0532 0.0483
Echinococcus granulosus dna polymerase kappa 0.0247 0.2827 0.279
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0126 0.0075
Brugia malayi polk-prov protein 0.0077 0.0705 0.115
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0226 0.0401
Leishmania major hypothetical protein, conserved 0.0038 0.0226 0.0401
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0039 0.023 0.0408
Giardia lamblia Pantothenate kinase 4 0.0079 0.0737 0.2471
Trichomonas vaginalis pantothenate kinase, putative 0.0079 0.0737 0.2471
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1084 0.1147
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.257 0.4454
Entamoeba histolytica phosphoinositide kinase, putative 0.0039 0.023 0.0712
Loa Loa (eye worm) pantothenate kinase 0.0079 0.0737 0.124
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0705 0.1251
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0039 0.023 0.0314
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0039 0.023 0.0642
Echinococcus granulosus glutamate receptor 2 0.0025 0.0058 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.5523 0.55
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0152 0.027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0073 0.0662 0.0613
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0 0.5
Echinococcus granulosus GPCR family 2 0.0063 0.0532 0.0483
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.257 0.2532
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0104 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.1872 0.3323
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0554 0.0984
Mycobacterium ulcerans hypothetical protein 0.0077 0.0705 0.2065
Mycobacterium leprae Probable lipase LipE 0.0107 0.1084 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0247 0.2827 0.3293
Entamoeba histolytica hypothetical protein 0.0107 0.1078 0.3747
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.2222 0.3821
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.038 0.2447
Loa Loa (eye worm) hypothetical protein 0.0032 0.0152 0.0214
Schistosoma mansoni DNA polymerase IV / kappa 0.0077 0.0705 0.0657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0117 0.0066
Leishmania major DNA polymerase eta, putative 0.0473 0.5633 1
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0226 0.0175
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0039 0.023 0.0408
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1191 0.2035
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2667 0.9422
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1084 0.3719
Echinococcus granulosus importin subunit beta 1 0.0033 0.016 0.0109
Plasmodium vivax pantothenate kinase, putative 0.0079 0.0737 0.5841
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0389 0.4585 0.4557
Brugia malayi jmjC domain containing protein 0.0389 0.4585 0.7981
Onchocerca volvulus Fumble homolog 0.0079 0.0737 0.1105
Toxoplasma gondii ABC1 family protein 0.0107 0.1084 0.3087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0053
Brugia malayi AF-10 protein 0.0039 0.0232 0.0318
Mycobacterium tuberculosis Conserved protein 0.0107 0.1084 0.1147
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0039 0.023 0.0642
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.016 0.0284
Echinococcus granulosus neuropeptide s receptor 0.0464 0.5523 0.55
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0039 0.023 0.0408
Echinococcus multilocularis expressed protein 0.0066 0.0574 0.0525
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0039 0.023 0.0654
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.1848
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0039 0.023 0.0179
Trypanosoma cruzi DNA polymerase eta, putative 0.0473 0.5633 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0152 0.0063
Schistosoma mansoni hypothetical protein 0.0119 0.1226 0.118
Echinococcus granulosus lysine specific demethylase 5A 0.0144 0.1536 0.1493
Entamoeba histolytica hypothetical protein 0.0027 0.0082 0.0185
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0039 0.023 0.0408
Brugia malayi beta-lactamase family protein 0.0107 0.1084 0.1817
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0302 0.3511 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0334
Schistosoma mansoni DNA polymerase eta 0.0473 0.5633 0.561
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Leishmania major DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0247 0.2827 0.279
Loa Loa (eye worm) PHD-finger family protein 0.0119 0.1226 0.2097
Brugia malayi MH2 domain containing protein 0.0116 0.1191 0.2006
Echinococcus granulosus expressed protein 0.0066 0.0574 0.0525
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.257 0.2532
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0226 0.0175
Trypanosoma brucei chrX additional, unordered contigs 0.0077 0.0705 0.1251
Onchocerca volvulus 0.0107 0.1084 0.1722
Trichomonas vaginalis pantothenate kinase, putative 0.0079 0.0737 0.2471
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0152 0.0434
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0198 0.0147
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0053
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1084 0.3719
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0532 0.0846
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0106 0.0465
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0073 0.0662 0.0613
Schistosoma mansoni ATP-binding cassette transporter 0.003 0.0126 0.0075
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0039 0.023 0.0179
Brugia malayi photoreceptor-specific nuclear receptor 0.0249 0.2843 0.4914
Leishmania major DNA damage repair protein, putative 0.0077 0.0705 0.1251
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0065 0.0554 0.0984
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0039 0.023 0.0408
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0247 0.2827 0.279
Loa Loa (eye worm) hypothetical protein 0.0051 0.038 0.0614
Loa Loa (eye worm) hypothetical protein 0.0051 0.038 0.0614
Schistosoma mansoni pyruvate kinase 0.0032 0.0152 0.0101
Onchocerca volvulus 0.0299 0.3471 0.5974
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1084 0.1038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0117 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.257 0.2532
Onchocerca volvulus 0.0038 0.0224 0.0191
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0226 0.0175
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0481 0.5732 0.571
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1084 0.3719
Trypanosoma brucei unspecified product 0.0171 0.1872 0.3323
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1084 0.3483
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1084 0.1147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0334
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.1517
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0066 0.0574 0.0953
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1078 0.1032
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0073 0.0662 0.0613
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.003 0.0126 0.0075
Mycobacterium tuberculosis Conserved protein 0.0107 0.1084 0.1147
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0152 0.0214
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0247 0.2827 0.4905
Onchocerca volvulus 0.0107 0.1084 0.1722
Echinococcus granulosus phd:f box containing protein 0.0038 0.0226 0.0175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0117 0.0066
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0077 0.0705 0.2007
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.1872 0.3323
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0106 0.0465
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0058 0.0007
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0226 0.0644
Schistosoma mansoni jumonji domain containing protein 0.0309 0.3591 0.3558
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0051 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0247 0.2827 0.5019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0532 0.0483
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.038 0.0675
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0077 0.0705 0.2007
Trypanosoma brucei unspecified product 0.0171 0.1872 0.3323
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0039 0.023 0.0408
Mycobacterium tuberculosis Conserved protein 0.0107 0.1084 0.1147
Brugia malayi Pip kinase protein 2 0.0481 0.5732 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0246 0.0195
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0039 0.023 0.1517
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.2222 0.3821
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0082 0.0111
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.038 0.0852
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0152 0.0063
Mycobacterium ulcerans hypothetical protein 0.0051 0.038 0.0852
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0195 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0144 0.1536 0.1493
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.038 0.0852
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0226 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0051 0.038 0.0579
Echinococcus granulosus jumonji domain containing protein 0.0165 0.1804 0.1762
Schistosoma mansoni hypothetical protein 0.0824 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.038 0.0852
Echinococcus multilocularis NMDA receptor 0.0049 0.0353 0.0303
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0246 0.0342
Loa Loa (eye worm) pip kinase 1 0.0039 0.023 0.0349
Giardia lamblia DNA damage repair protein 0.0077 0.0705 0.2353
Echinococcus granulosus single minded 2 0.0038 0.0224 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0167 0.0982
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0152 0.027
Onchocerca volvulus 0.0051 0.038 0.0469
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0049 0.0353 0.0303
Mycobacterium ulcerans lipase LipD 0.0107 0.1084 0.3483
Loa Loa (eye worm) hypothetical protein 0.0038 0.0226 0.0343
Giardia lamblia PHD finger protein 15 0.0119 0.1226 0.4231
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0226 0.0175
Entamoeba histolytica pantothenate kinase 1, putative 0.0079 0.0737 0.2528
Entamoeba histolytica hypothetical protein 0.0107 0.1078 0.3747
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.257 0.4434
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0051 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0705 0.1251
Brugia malayi beta-lactamase 0.0107 0.1084 0.1817
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.5523 0.55
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1084 0.1924
Trypanosoma cruzi DNA damage repair protein, putative 0.0077 0.0705 0.1251
Echinococcus multilocularis pyruvate kinase 0.0032 0.0152 0.0101
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0221 0.0084
Leishmania major hypothetical protein, conserved 0.0107 0.1084 0.1924
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0039 0.023 0.0408
Echinococcus granulosus pyruvate kinase 0.0032 0.0152 0.0101
Trichomonas vaginalis DNA polymerase eta, putative 0.0247 0.2827 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0036 0.0198 0.0147
Plasmodium falciparum pyruvate kinase 0.0032 0.0152 0.0859
Trypanosoma brucei pantothenate kinase subunit, putative 0.0082 0.0763 0.1355
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0082 0.0763 0.1355
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0152 0.0859
Loa Loa (eye worm) hypothetical protein 0.0299 0.3471 0.6035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1084 0.1038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0284 0.0445
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.038 0.0281
Schistosoma mansoni hypothetical protein 0.0039 0.0232 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0106 0.0188
Brugia malayi hypoxia-induced factor 1 0.016 0.1735 0.2963
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0117 0.0333
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0226 0.0343
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1084 0.8791
Trypanosoma brucei DNA polymerase eta, putative 0.0473 0.5633 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0082 0.0111
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0408
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0226 0.0401
Echinococcus granulosus pantothenate kinase 4 0.0079 0.0737 0.069
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.1848
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0039 0.023 0.0179
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0408
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1084 0.1147
Trypanosoma brucei DNA damage repair protein, putative 0.0077 0.0705 0.1251
Brugia malayi RNA, U transporter 1 0.0094 0.0916 0.1523
Schistosoma mansoni terminal deoxycytidyl transferase 0.0247 0.2827 0.279
Trichomonas vaginalis rotamase, putative 0.0065 0.0554 0.1811
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0712
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.038 0.0852
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0232 0.1537
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0685 0.8275 1
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0226 0.0175
Schistosoma mansoni pyruvate kinase 0.0032 0.0152 0.0101
Plasmodium falciparum importin beta, putative 0.0033 0.016 0.0923
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0039 0.023 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.1226 0.3492
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0221 0.1442
Brugia malayi jmjC domain containing protein 0.0038 0.0226 0.0307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.257 0.2532
Plasmodium vivax hypothetical protein, conserved 0.0119 0.1226 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Echinococcus multilocularis jumonji domain containing protein 0.0165 0.1804 0.1762
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0082 0.0146
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0232 0.0412
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.4131 0.7191
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0232 0.0661
Loa Loa (eye worm) jmjC domain-containing protein 0.0245 0.2798 0.4854
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0152 0.027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.038 0.1251
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0066 0.0574 0.0919
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0221 0.1442
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0051 0.0147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1084 0.1848
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2313 0.4003
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0232 0.0412
Loa Loa (eye worm) hypothetical protein 0.0077 0.0705 0.1182
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.0554 0.1873
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0705 0.1251
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0227
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0039 0.023 0.0654
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0106 0.0465
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0532 0.0879
Echinococcus granulosus glutamate NMDA receptor subunit 0.003 0.0126 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0144 0.1536 0.2641
Brugia malayi jmjC domain containing protein 0.0038 0.0226 0.0307
Entamoeba histolytica Ran family GTPase 0.0024 0.0051 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0133
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.038 0.1251
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0705 0.1251
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Loa Loa (eye worm) glutamate receptor 2 0.003 0.0126 0.0168
Loa Loa (eye worm) hypothetical protein 0.0039 0.0232 0.0353
Loa Loa (eye worm) hypothetical protein 0.0051 0.038 0.0614
Brugia malayi PHD-finger family protein 0.0039 0.0232 0.0318
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0039 0.023 0.0408
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0152 0.0363
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1084 0.1147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0082 0.0111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1084 0.1817
Loa Loa (eye worm) hypothetical protein 0.0204 0.2281 0.3947
Toxoplasma gondii peptidylprolyl isomerase 0.0065 0.0554 0.1578
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.0152
Echinococcus multilocularis pyruvate kinase 0.0026 0.0067 0.0016
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.038 0.0852
Loa Loa (eye worm) hypothetical protein 0.0043 0.0284 0.0445
Mycobacterium tuberculosis Conserved hypothetical protein 0.0247 0.2827 0.3293
Brugia malayi Glutamate receptor 2 precursor 0.003 0.0126 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.257 0.2532
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0247 0.2827 0.279
Schistosoma mansoni glutamate receptor kainate 0.003 0.0126 0.0075
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0224 0.0174
Leishmania major pantothenate kinase subunit, putative 0.0082 0.0763 0.1355
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0039 0.023 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Trypanosoma cruzi DNA polymerase eta, putative 0.0302 0.3511 0.6232
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1084 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0481 0.5732 0.571
Brugia malayi hypothetical protein 0.0043 0.0284 0.041
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0117 0.0066
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0152 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0171 0.1872 0.3323
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0483
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0408
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0705 0.1251
Leishmania major hypothetical protein, conserved 0.0029 0.0106 0.0188
Giardia lamblia Pyruvate kinase 0.0032 0.0152 0.0363
Trichomonas vaginalis rotamase, putative 0.0066 0.0574 0.1881
Brugia malayi hypothetical protein 0.0043 0.0284 0.041
Plasmodium vivax SET domain protein, putative 0.003 0.0117 0.0559
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1084 0.1924
Brugia malayi AMP-binding enzyme family protein 0.0051 0.038 0.0579
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.1848
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0039 0.023 0.0349
Echinococcus multilocularis snurportin 1 0.0352 0.4131 0.41
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.2222 0.3844
Brugia malayi Pip kinase protein 1 0.0039 0.023 0.0314
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0391 0.0341
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0039 0.023 0.0408
Plasmodium vivax JmjC domain containing protein 0.0038 0.0226 0.1486
Brugia malayi Glutamate receptor 1 precursor 0.003 0.0126 0.0132
Brugia malayi Pre-SET motif family protein 0.0206 0.2313 0.398
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0073 0.0662 0.0613
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0065 0.0554 0.0984
Trichomonas vaginalis pantothenate kinase, putative 0.0079 0.0737 0.2471
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0483
Echinococcus multilocularis peregrin 0.0119 0.1226 0.118
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0198 0.0147
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0221 0.0256
Schistosoma mansoni glutamate receptor kainate 0.0068 0.059 0.0542
Echinococcus granulosus peregrin 0.0119 0.1226 0.118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.038 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0117 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0334
Brugia malayi hypothetical protein 0.0299 0.3471 0.602
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.954 0.9538
Echinococcus multilocularis expressed conserved protein 0.0043 0.0284 0.0234
Brugia malayi jmjC domain containing protein 0.0144 0.1536 0.2614
Brugia malayi AMP-binding enzyme family protein 0.0051 0.038 0.0579
Mycobacterium ulcerans DNA polymerase IV 0.0247 0.2827 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0532 0.0879
Echinococcus granulosus expressed conserved protein 0.0043 0.0284 0.0234
Onchocerca volvulus 0.0235 0.2667 0.4541
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1084 0.1038
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0226 0.0175
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0226 0.0175
Schistosoma mansoni importin beta-1 0.0033 0.016 0.0109
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.0705 0.1251
Schistosoma mansoni jumonji/arid domain-containing protein 0.0144 0.1536 0.1493
Loa Loa (eye worm) beta-lactamase 0.0107 0.1084 0.1848
Schistosoma mansoni hypothetical protein 0.0063 0.0532 0.0483
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0642
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0226 0.0175
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0152 0.0178
Leishmania major pyruvate kinase 0.0032 0.0152 0.027
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0226 0.0175
Trypanosoma brucei DNA damage repair protein, putative 0.0077 0.0705 0.1251
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0226 0.0175
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0532 0.0483
Plasmodium falciparum DNA repair protein REV1, putative 0.0077 0.0705 0.5562
Trichomonas vaginalis esterase, putative 0.0107 0.1084 0.3719
Brugia malayi ImpB/MucB/SamB family protein 0.0247 0.2827 0.4886
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0039 0.023 0.0179
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.144 0.2444
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1084 0.1147
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1084 0.1147
Leishmania major DNA polymerase eta, putative 0.0302 0.3511 0.6232
Brugia malayi jmjC domain containing protein 0.0038 0.0226 0.0307
Loa Loa (eye worm) glutamate receptor 1 0.003 0.0126 0.0168
Schistosoma mansoni glutamate receptor kainate 0.0068 0.059 0.0542
Echinococcus multilocularis importin subunit beta 1 0.0033 0.016 0.0109
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1084 0.1147
Brugia malayi PAS domain containing protein 0.0052 0.0391 0.0597
Trypanosoma cruzi DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Trypanosoma brucei DNA polymerase IV, putative 0.0247 0.2827 0.5019
Brugia malayi jmjC domain containing protein 0.0038 0.0226 0.0307
Toxoplasma gondii PHD-finger domain-containing protein 0.0119 0.1226 0.3492
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0226 0.0343
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0152 0.0178
Plasmodium vivax importin-beta 2, putative 0.0033 0.016 0.0923
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0334
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0224 0.0268
Trichomonas vaginalis pantothenate kinase, putative 0.0079 0.0737 0.2471
Brugia malayi hypothetical protein 0.0173 0.1901 0.3256
Schistosoma mansoni rotamase 0.0066 0.0574 0.0525
Trypanosoma cruzi DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Leishmania major pyruvate kinase 0.0032 0.0152 0.027
Echinococcus multilocularis pyruvate kinase 0.0032 0.0152 0.0101
Brugia malayi pantothenate kinase family protein 0.0079 0.0737 0.1208
Brugia malayi beta-lactamase family protein 0.0107 0.1084 0.1817
Loa Loa (eye worm) hypothetical protein 0.0038 0.0226 0.0343
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0126 0.0075
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0106 0.0188
Loa Loa (eye worm) hypothetical protein 0.0249 0.2843 0.4933
Plasmodium falciparum pantothenate kinase 1, putative 0.0079 0.0737 0.5841
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0049 0.0353 0.0303
Trypanosoma brucei DNA polymerase IV, putative 0.0247 0.2827 0.5019
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1084 0.1924
Onchocerca volvulus 0.0107 0.1084 0.1722
Leishmania major GTP-binding protein, putative 0.0024 0.0051 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0106 0.0188
Toxoplasma gondii fumble protein 0.0079 0.0737 0.2101
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0126 0.0075
Trypanosoma cruzi DNA damage repair protein, putative 0.0077 0.0705 0.1251
Trichomonas vaginalis pantothenate kinase, putative 0.0079 0.0737 0.2471
Loa Loa (eye worm) hypothetical protein 0.0481 0.5732 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0226 0.0175
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1084 0.1038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0117 0.0066
Echinococcus multilocularis PHD finger protein rhinoceros 0.0119 0.1226 0.118
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0065 0.0554 0.0984
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.1848
Leishmania major importin beta-1 subunit, putative 0.0027 0.0082 0.0146
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.038 0.2447
Brugia malayi Bromodomain containing protein 0.0119 0.1226 0.2067
Loa Loa (eye worm) hypothetical protein 0.0107 0.1084 0.1848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.257 0.2532
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0226 0.0175
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0049 0.0353 0.0303
Echinococcus granulosus PHD finger protein rhinoceros 0.0119 0.1226 0.118
Echinococcus multilocularis pantothenate kinase 4 0.0079 0.0737 0.069
Brugia malayi Pre-SET motif family protein 0.003 0.0117 0.0115
Brugia malayi Importin beta-1 subunit 0.0033 0.016 0.0191
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0232 0.0661
Echinococcus multilocularis glutamate receptor 2 0.003 0.0126 0.0075
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.016 0.0455
Leishmania major DNA polymerase kappa, putative 0.0077 0.0705 0.1251
Schistosoma mansoni pantothenate kinase 0.0079 0.0737 0.069
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0481 0.5732 0.571
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0152 0.0214
Schistosoma mansoni hypothetical protein 0.0107 0.1078 0.1032
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0226 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.038 0.0852
Entamoeba histolytica hypothetical protein 0.0107 0.1078 0.3747
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0039 0.023 0.0654
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0152 0.0063
Brugia malayi ImpB/MucB/SamB family protein 0.0473 0.5633 0.9825
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1084 0.3483
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1078 0.1032
Plasmodium vivax hypothetical protein, conserved 0.0039 0.023 0.1517
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0039 0.023 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0117 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0532 0.0483
Loa Loa (eye worm) hypothetical protein 0.0173 0.1901 0.3281
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0221 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0073 0.0662 0.0613
Entamoeba histolytica hypothetical protein 0.0107 0.1078 0.3747
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0082 0.0763 0.1355
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0226 0.0644
Loa Loa (eye worm) FYVE zinc finger family protein 0.0039 0.023 0.0349
Plasmodium falciparum phd finger protein, putative 0.0119 0.1226 1
Schistosoma mansoni single-minded 0.0052 0.0391 0.0341
Loa Loa (eye worm) hypothetical protein 0.0473 0.5633 0.9826
Loa Loa (eye worm) hypoxia-induced factor 1 0.016 0.1735 0.2989
Loa Loa (eye worm) pip kinase 2 0.0481 0.5732 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.032 0.0968
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0481 0.5732 0.571
Schistosoma mansoni hypothetical protein 0.0352 0.4131 0.41
Echinococcus multilocularis dna polymerase eta 0.0473 0.5633 0.561
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.5523 0.55
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1084 0.3719
Plasmodium vivax DNA repair protein REV1, putative 0.0077 0.0705 0.5562
Schistosoma mansoni hypothetical protein 0.0824 1 1
Schistosoma mansoni hypothetical protein 0.0136 0.144 0.1396
Loa Loa (eye worm) hypothetical protein 0.0136 0.144 0.2472
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0152 0.0214
Plasmodium falciparum JmjC domain-containing protein, putative 0.0038 0.0226 0.1486
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1078 0.1032
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0036 0.0198 0.0147
Giardia lamblia DINP protein human, muc B family 0.0247 0.2827 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0226 0.0343
Giardia lamblia Hypothetical protein 0.0039 0.023 0.0642
Echinococcus multilocularis geminin 0.0824 1 1
Onchocerca volvulus Alhambra homolog 0.0119 0.1226 0.1975
Trypanosoma brucei unspecified product 0.0247 0.2827 0.5019
Echinococcus granulosus snurportin 1 0.0352 0.4131 0.41
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0051 0.0091
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0152 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0247 0.2827 0.5019
Echinococcus granulosus glutamate receptor 2 0.0036 0.0198 0.0147
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0049 0.0353 0.0303
Mycobacterium ulcerans DNA polymerase IV 0.0247 0.2827 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0247 0.2827 0.5019
Echinococcus multilocularis GPCR, family 2 0.0063 0.0532 0.0483
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.038 0.0675
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0106 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1191 0.2035
Entamoeba histolytica deoxycytidyl transferase, putative 0.0247 0.2827 1
Brugia malayi PHD-finger family protein 0.0119 0.1226 0.2067
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0224 0.0304
Onchocerca volvulus 0.0481 0.5732 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0232 0.1537
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.038 0.1251
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0039 0.023 0.0408
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0226 0.0175
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0073 0.0662 0.0613
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.257 0.2532
Toxoplasma gondii pantothenate kinase 0.0034 0.0167 0.0475
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0039 0.023 0.0408
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0532 0.0846
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1084 0.3719
Echinococcus granulosus pyruvate kinase 0.0032 0.0152 0.0101
Loa Loa (eye worm) hypothetical protein 0.0199 0.2222 0.3844

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3673 nM Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cells ChEMBL. 21619066
Ki (binding) = 72300 nM Displacement of [3H]SYM2081 from rat GluK3 expressed in Sf9 cells ChEMBL. 21619066
Ki (binding) > 100000 nM Displacement of [3H]AMPA from rat GluA2 expressed in Sf9 cells ChEMBL. 21619066
Ki (binding) > 1000000 nM Displacement of [3H]SYM2081 from rat GluK2 expressed in Sf9 cells ChEMBL. 21619066

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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