Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0172 | 0.0172 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0712 | 0.0712 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0488 | 0.0488 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0712 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0712 | 0.0712 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0172 | 0.055 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0172 | 0.0172 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.0488 | 0.1556 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0172 | 0.0172 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.035 | 0.035 |
Echinococcus multilocularis | smad | 0.0008 | 0.0172 | 0.055 |
Echinococcus granulosus | smad | 0.0008 | 0.0172 | 0.055 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.0488 | 0.0488 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0172 | 0.055 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0172 | 0.055 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0712 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.0488 | 0.1556 |
Brugia malayi | Smad1 | 0.0008 | 0.0172 | 0.0172 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0172 | 0.055 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.0488 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.3135 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.3135 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.3135 | 0.3135 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3135 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.3135 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.0488 | 0.1556 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0172 | 0.055 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0172 | 0.0172 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.0488 | 0.0488 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0488 | 0.1556 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0172 | 0.055 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.0488 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0488 | 0.0488 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0172 | 0.055 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.0488 | 0.0488 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0172 | 0.055 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0488 | 0.1556 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0488 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0488 | 0.0488 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0172 | 0.055 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.0488 | 0.0488 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.0712 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.0488 | 0.1556 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0488 | 0.1556 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.0488 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.0488 | 0.1556 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0712 | 0.0712 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.0488 | 0.0488 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0488 | 0.1556 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.0712 | 0.0712 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.0488 | 0.1556 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0172 | 0.055 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.0488 | 0.1556 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.0488 | 0.0488 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3135 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 1 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0172 | 0.0172 |
Schistosoma mansoni | smad | 0.0008 | 0.0172 | 0.055 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.0488 | 0.0488 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.0488 | 0.0488 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0488 | 0.1556 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0712 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0712 | 0.0712 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.0488 | 0.0488 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.0488 | 0.1556 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0712 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.0488 | 0.1556 |
Onchocerca volvulus | 0.0012 | 0.0488 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.0488 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.0488 | 0.1556 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0172 | 0.055 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.0488 | 0.1556 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.3135 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0172 | 0.0172 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.0488 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0488 | 0.0488 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.3135 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.