TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.272 | Formula: C21H17BrF2N2O3
H donors: 1 H acceptors: 2 LogP: 3.85 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)COc1cc(C)n(c(=O)c1Br)c1cc(ccc1C)C(=O)N
InChi: 1S/C21H17BrF2N2O3/c1-11-3-4-13(20(25)27)8-17(11)26-12(2)7-18(19(22)21(26)28)29-10-14-5-6-15(23)9-16(14)24/h3-9H,10H2,1-2H3,(H2,25,27)
InChiKey: LHJZWNSLAVIXQG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	LsmAD domain-containing protein	0.0058	0.1571	0.7439
Loa Loa (eye worm)	fibroinase	0.002	0.0239	0.0378
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.2072	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0239	0.2197
Echinococcus multilocularis	dna polymerase eta	0.0022	0.03	0.0475
Echinococcus granulosus	lamin	0.0027	0.0485	0.0767
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.1505	0.1496
Leishmania major	cathepsin L-like protease	0.002	0.0239	0.0279
Echinococcus granulosus	cathepsin l1	0.002	0.0239	0.0378
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0254	0.0402
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0485	0.0767
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0254	0.0943
Loa Loa (eye worm)	hypothetical protein	0.002	0.0239	0.0378
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0043	0.1051	0.1662
Plasmodium vivax	glutathione reductase, putative	0.0047	0.1191	0.7385
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0961	0.9141
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1137	0.1799
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0485	0.0752
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1137	0.1799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Brugia malayi	hypothetical protein	0.0038	0.0854	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0961	0.1521
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.3714	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0043	0.1051	0.1662
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0239	0.0378
Brugia malayi	PHD-finger family protein	0.003	0.0582	0.0905
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.03	0.2786
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0239	0.0378
Brugia malayi	Thioredoxin reductase	0.0047	0.1191	0.1871
Plasmodium falciparum	phd finger protein, putative	0.003	0.0582	0.3194
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0098	0.2934	0.464
Loa Loa (eye worm)	hypothetical protein	0.005	0.1267	0.2005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0117	0.0106
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0254	0.0701
Onchocerca volvulus		0.002	0.0239	0.0393
Plasmodium falciparum	thioredoxin reductase	0.0047	0.1191	0.7385
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.3714	0.4251
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0254	0.0386
Brugia malayi	Cathepsin L-like precursor	0.002	0.0239	0.0362
Echinococcus granulosus	peregrin	0.003	0.0582	0.092
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0117	0.1025
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.4819	0.7621
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0961	0.9141
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0239	0.0838
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0239	0.2197
Echinococcus multilocularis	lamin	0.0027	0.0485	0.0767
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.1267	0.1258
Echinococcus multilocularis	cysteine protease	0.002	0.0239	0.0378
Leishmania major	cathepsin L-like protease	0.002	0.0239	0.0279
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0043	0.1051	1
Leishmania major	cathepsin L-like protease	0.0076	0.2182	0.4402
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0582	0.092
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0254	0.0395
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0026	0.0455	0.072
Treponema pallidum	NADH oxidase	0.0016	0.0117	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0058	0.1571	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.03	0.0409
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0239	0.0378
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.03	0.0491
Onchocerca volvulus		0.0041	0.0961	0.1634
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0961	0.4318
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0961	0.4318
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0254	0.0943
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.4819	0.7621
Leishmania major	hypothetical protein, conserved	0.0041	0.0961	0.1812
Echinococcus multilocularis	geminin	0.0173	0.5557	0.8789
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.3296	0.3757
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0961	0.0998
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1051	0.2002
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0195	0.6323	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0153	0.4851	0.7671
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0117	0.0107
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0582	0.092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0239	0.0362
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0239	0.0393
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.03	0.0491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.1051	1
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.1191	0.7385
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0017
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.3296	0.3757
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0016	0.0107	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0961	0.1521
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.03	0.0937
Schistosoma mansoni	alpha-glucosidase	0.0168	0.5377	0.5373
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.03	0.0475
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0254	0.0386
Leishmania major	cathepsin L-like protease	0.0076	0.2182	0.4402
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.1267	0.1258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0485	0.0475
Loa Loa (eye worm)	cysteine protease	0.002	0.0239	0.0378
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.1051	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0239	0.0362
Brugia malayi	Cathepsin L-like precursor	0.002	0.0239	0.0362
Schistosoma mansoni	hypothetical protein	0.003	0.0582	0.0572
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Mycobacterium tuberculosis	Probable reductase	0.0108	0.3296	0.3757
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.2072	0.4169
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1505	0.2381
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Brugia malayi	Bromodomain containing protein	0.003	0.0582	0.0905
Echinococcus granulosus	intermediate filament protein	0.0027	0.0485	0.0767
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.03	0.2786
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.03	0.0475
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0117	0.0021
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.3296	0.3757
Brugia malayi	hypothetical protein	0.0181	0.5829	0.9222
Plasmodium vivax	vivapain-2	0.002	0.0239	0.0838
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.1051	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1051	0.2002
Plasmodium vivax	vivapain-2	0.002	0.0239	0.0838
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0195	0.6321	0.9996
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.1505	0.2369
Onchocerca volvulus		0.002	0.0239	0.0393
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0961	0.9141
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.03	0.0409
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Brugia malayi	beta-lactamase	0.0041	0.0961	0.1507
Loa Loa (eye worm)	RecQ helicase	0.002	0.0254	0.0402
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.03	0.0459
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0961	0.0998
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0043	0.1051	1
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.1267	0.2004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0799	0.079
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.1191	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0051	0.132	0.2089
Echinococcus multilocularis	peregrin	0.003	0.0582	0.092
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0239	0.0378
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1137	0.1128
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0107	0.0933
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0026	0.0455	0.072
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.1267	0.2004
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0254	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1571	0.2486
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0107	0.0933
Echinococcus granulosus	dna polymerase kappa	0.0022	0.03	0.0475
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0117	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.2072	0.2064
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.03	0.2786
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.1191	0.1884
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.017
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0107	0.0933
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0961	0.0998
Leishmania major	cathepsin L-like protease	0.0076	0.2182	0.4402
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.2182	0.4402
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0239	0.0838
Brugia malayi	Cathepsin L-like precursor	0.002	0.0239	0.0362
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0107	0.0933
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0107	0.0933
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0195	0.6321	1
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0582	0.3194
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.1571	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0961	0.1521
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0961	0.5805
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0043	0.1051	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0961	0.1812
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.2182	0.4402
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.3296	0.3757
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Schistosoma mansoni	alpha-glucosidase	0.0168	0.5377	0.5373
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0254	0.0311
Onchocerca volvulus		0.0027	0.0485	0.0815
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.2072	1
Leishmania major	cathepsin L-like protease	0.002	0.0239	0.0279
Onchocerca volvulus		0.002	0.0239	0.0393
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0254	0.2343
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.4819	1
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0254	0.2343
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0485	0.0767
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0239	0.0279
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0117	0.0185
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0254	0.0701
Onchocerca volvulus	Alhambra homolog	0.003	0.0582	0.0982
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0117	0.0185
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.03	0.0216
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.1051	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0239	0.0393
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0799	0.1264
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.1267	0.2004
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.03	0.0409
Toxoplasma gondii	thioredoxin reductase	0.0047	0.1191	0.5493
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.4819	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1137	0.1799
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0107	0.0933
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0961	0.1521
Schistosoma mansoni	hypothetical protein	0.0173	0.5557	0.5553
Onchocerca volvulus		0.002	0.0239	0.0393
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.2072	0.3277
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.3714	0.4251
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0254	0.0402
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0016	0.0107	0.0167
Onchocerca volvulus		0.002	0.0239	0.0393
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.03	0.0491
Loa Loa (eye worm)	hypothetical protein	0.003	0.0582	0.092
Onchocerca volvulus		0.002	0.0239	0.0393
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0961	0.0998
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.4819	0.7621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Onchocerca volvulus		0.0041	0.0961	0.1634
Brugia malayi	mbt repeat family protein	0.005	0.1267	0.1991
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0961	0.1521
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0142	0.4457	0.7048
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0017
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.1267	0.2005
Onchocerca volvulus		0.002	0.0239	0.0393
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0961	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0017
Echinococcus granulosus	cathepsin l1	0.0013	0.001	0.0017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1137	0.1128
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.2072	0.231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0239	0.0838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.03	0.0409
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0117	0.0021
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.1137	0.1786
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.4819	1
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.1267	0.1258
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.1191	0.1883
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0961	0.4318
Schistosoma mansoni	thyroid hormone receptor	0.0153	0.4851	0.4845
Loa Loa (eye worm)	hypothetical protein	0.0022	0.03	0.0475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0117	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0799	0.079
Echinococcus multilocularis	musashi	0.0027	0.0485	0.0767
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0239	0.2197
Giardia lamblia	DINP protein human, muc B family	0.0022	0.03	0.3941
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1137	0.1799
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.03	0.0459
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0961	0.1507
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.1267	0.2004
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0254	0.0402
Echinococcus granulosus	lamin dm0	0.0027	0.0485	0.0767
Leishmania major	DNA polymerase eta, putative	0.0022	0.03	0.0409
Leishmania major	alpha glucosidase II subunit, putative	0.0043	0.1051	0.2002
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0254	0.2343
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.1191	0.1883
Schistosoma mansoni	hypothetical protein	0.0026	0.0455	0.0445
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0961	0.0998
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0261	0.8579	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0239	0.0229
Brugia malayi	intermediate filament protein	0.0027	0.0485	0.0752
Echinococcus multilocularis	cysteine protease	0.002	0.0239	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0468	0.074
Schistosoma mansoni	thyroid hormone receptor	0.0153	0.4851	0.4845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0107	0.0154
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0582	0.2376
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.4819	0.7621
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0043	0.1051	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0181	0.5829	0.9223
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.4819	0.7621
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0961	0.4318
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.2072	0.2064
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0987	0.156
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Loa Loa (eye worm)	ctsf protein	0.002	0.0239	0.0378
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0961	0.9141
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0254	0.0402
Schistosoma mansoni	hypothetical protein	0.0173	0.5557	0.5553
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0961	0.9141
Schistosoma mansoni	jumonji domain containing protein	0.0078	0.2238	0.223
Mycobacterium ulcerans	lipase LipD	0.0041	0.0961	0.4318
Schistosoma mansoni	alpha glucosidase	0.0043	0.1051	0.1041
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0582	0.2376
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.2072	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0195	0.6321	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0254	0.0402
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.1571	0.3107
Onchocerca volvulus		0.005	0.1267	0.216
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.1505	0.238
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0107	0.0933
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.03	0.029
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0117	0.0169
Trypanosoma brucei	unspecified product	0.0022	0.03	0.0491
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0987	0.156
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0043	0.1051	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0485	0.0767
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0016	0.0107	0.0086
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.1267	0.216
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0582	0.092
Trypanosoma brucei	trypanothione reductase	0.0047	0.1191	0.2366
Schistosoma mansoni	hypothetical protein	0.0142	0.4457	0.4451
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.3714	0.4251
Echinococcus granulosus	bloom syndrome protein	0.002	0.0254	0.0402
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.03	0.0409
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0254	0.0386
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0069	0.1953	0.3917
Trypanosoma cruzi	major cysteine proteinase, putative	0.006	0.1618	0.3206
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.1683	0.2662
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.03	0.0491
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.03	0.0409
Loa Loa (eye worm)	glutathione reductase	0.0047	0.1191	0.1884
Plasmodium falciparum	glutathione reductase	0.0047	0.1191	0.7385
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.1191	0.23
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0239	0.0378
Brugia malayi	P38 map kinase family protein 2	0.0152	0.4819	0.7621
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0254	0.0402
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0961	0.1812
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0961	0.152
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0961	0.0998
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0961	0.0952
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.03	0.029
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.005	0.0079
Loa Loa (eye worm)	MBCTL1	0.0056	0.1505	0.2381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0195	0.6321	0.9996
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0961	0.0998
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1137	0.1128
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0239	0.0229
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0961	0.0998
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0239	0.0279
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Brugia malayi	beta-lactamase family protein	0.0041	0.0961	0.1507
Brugia malayi	hypothetical protein	0.0058	0.1571	0.2473
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.03	0.0216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0239	0.2197
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.3296	0.3757
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.1505	0.238
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0117	0.0106
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0117	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0239	0.0378
Trypanosoma brucei	PAB1-binding protein , putative	0.0058	0.1571	0.3166
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0485	0.0767
Echinococcus granulosus	lysosomal alpha glucosidase	0.0195	0.6321	0.9996
Brugia malayi	jmjC domain containing protein	0.0036	0.0799	0.125
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.4819	0.7621
Leishmania major	trypanothione reductase	0.0047	0.1191	0.23
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Schistosoma mansoni	DNA helicase recq1	0.002	0.0254	0.0244
Brugia malayi	Cathepsin L-like precursor	0.002	0.0239	0.0362
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0239	0.0378
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0098	0.2934	0.464
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.03	0.0475
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0117	0.0021
Leishmania major	DNA polymerase kappa, putative	0.0022	0.03	0.0409
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0117	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0961	0.1882
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.2072	0.3277
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0043	0.1051	0.1662
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0239	0.2197
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.03	0.0937
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Trichomonas vaginalis	esterase, putative	0.0041	0.0961	0.9141
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0961	0.0998
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0239	0.0393
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.0254	0.2951
Onchocerca volvulus		0.0113	0.3465	0.5937
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0043	0.1051	1
Schistosoma mansoni	lamin	0.0027	0.0485	0.0475
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0117	0.0106
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0582	0.0572
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0142	0.4457	0.7048
Echinococcus granulosus	dna polymerase eta	0.0022	0.03	0.0475
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.1505	0.238
Brugia malayi	mbt repeat family protein	0.005	0.1267	0.1991
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.1571	1
Toxoplasma gondii	cathepsin CPL	0.002	0.0239	0.0623
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0043	0.1051	0.4775
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0117	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Toxoplasma gondii	ABC1 family protein	0.0041	0.0961	0.4318
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0016	0.0107	0.0933
Trypanosoma cruzi	cruzipain precursor, putative	0.0076	0.2182	0.4402
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0254	0.2343
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0195	0.6323	1
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.4819	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0961	0.1521
Brugia malayi	Cathepsin L-like precursor	0.002	0.0239	0.0362
Schistosoma mansoni	DNA polymerase eta	0.0022	0.03	0.029
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0961	0.152
Trichomonas vaginalis	alpha-glucosidase, putative	0.0043	0.1051	1
Brugia malayi	jmjC domain containing protein	0.0098	0.2934	0.4633
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0239	0.2197
Onchocerca volvulus		0.0027	0.0485	0.0815
Trypanosoma brucei	glucosidase, putative	0.0043	0.1051	0.207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.1137	0.1799
Echinococcus granulosus	geminin	0.0173	0.5557	0.8789
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0961	0.1521
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.1505	0.238
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0961	0.1521
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0799	0.1264
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.03	0.0475
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.005	0.0062
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0117	0.0021
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.1571	0.3107
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0961	0.0952
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0239	0.0378
Leishmania major	cathepsin L-like protease	0.002	0.0239	0.0279
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.4819	0.7624
Leishmania major	cathepsin L-like protease	0.002	0.0239	0.0279
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.2182	0.4402
Giardia lamblia	PHD finger protein 15	0.003	0.0582	1
Onchocerca volvulus		0.0041	0.0961	0.1634
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.3296	0.8481
Brugia malayi	glutathione reductase	0.0047	0.1191	0.1871
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.03	0.0491
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0254	0.0402
Schistosoma mansoni	lamin	0.0027	0.0485	0.0475
Schistosoma mansoni	DNA helicase recq5	0.002	0.0254	0.0244
Leishmania major	hypothetical protein, conserved	0.0058	0.1571	0.3107
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0043	0.1051	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0117	0.0021
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0117	0.1025
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0799	0.1264
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0239	0.2197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.2182	0.445
Onchocerca volvulus		0.0181	0.5829	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.2072	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0961	0.1507

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2 nM	Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay	ChEMBL.	21641211
IC50 (functional)	= 2.5 nM	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release pretreated for 1 hr before LPS treatment measured after 18 hrs	ChEMBL.	21641211

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	21641211

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1802632

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1081460