Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.011 | 0.1327 | 0.1248 |
Schistosoma mansoni | lamin | 0.0029 | 0.0143 | 0.0388 |
Mycobacterium tuberculosis | Conserved protein | 0.011 | 0.1327 | 0.1248 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.011 | 0.1327 | 0.2886 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.011 | 0.1327 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.044 | 0.1191 |
Onchocerca volvulus | 0.011 | 0.1327 | 1 | |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 0.4021 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.011 | 0.1327 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.011 | 0.1327 | 0.3942 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.0706 | 0.2078 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0194 | 0.0544 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0295 | 0.4021 | 1 |
Trichomonas vaginalis | esterase, putative | 0.011 | 0.1327 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0706 | 0.1911 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0252 | 0.3397 | 0.7388 |
Brugia malayi | hypothetical protein | 0.0249 | 0.3346 | 1 |
Onchocerca volvulus | 0.0049 | 0.0432 | 0.3188 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.044 | 0.0956 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0252 | 0.3397 | 0.7388 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0194 | 0.0526 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0249 | 0.3346 | 0.7278 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0333 | 0.096 |
Brugia malayi | beta-lactamase family protein | 0.011 | 0.1327 | 0.3942 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1327 | 0.3942 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.011 | 0.1327 | 0.3594 |
Echinococcus multilocularis | ferritin | 0.0026 | 0.009 | 0.0196 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0013 | 0.0028 |
Leishmania major | hypothetical protein, conserved | 0.011 | 0.1327 | 0.1945 |
Onchocerca volvulus | 0.0029 | 0.0143 | 0.0993 | |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0026 | 0.009 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.0706 | 0.2078 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.011 | 0.1327 | 0.2715 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.011 | 0.1327 | 0.1248 |
Plasmodium vivax | hypothetical protein, conserved | 0.011 | 0.1327 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0748 | 0.2025 |
Mycobacterium tuberculosis | Conserved protein | 0.011 | 0.1327 | 0.1248 |
Schistosoma mansoni | ferritin | 0.0026 | 0.009 | 0.0245 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.1754 | 0.3871 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.044 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1327 | 0.3942 |
Toxoplasma gondii | ABC1 family protein | 0.011 | 0.1327 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0013 | 0.0028 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0143 | 0.0312 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0013 | 0.0028 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0249 | 0.3346 | 0.7278 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0015 | 0.0041 |
Schistosoma mansoni | lamin | 0.0029 | 0.0143 | 0.0388 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0013 | 0.0028 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0143 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1327 | 0.3942 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0194 | 0.0423 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.0706 | 0.2078 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0143 | 0.0312 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.1225 | 0.3635 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.027 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0013 | 0.0028 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0013 | 0.0028 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0273 | 0.3692 | 0.803 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.4021 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.4021 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0273 | 0.3692 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0013 | 0.0028 |
Schistosoma mansoni | apoferritin-2 | 0.0026 | 0.009 | 0.0245 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.027 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.027 | 0.073 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0458 | 0.124 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.1754 | 0.3223 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0455 | 0.0358 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.1225 | 0.3635 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0706 | 0.1911 |
Echinococcus multilocularis | expressed protein | 0.0026 | 0.009 | 0.0196 |
Mycobacterium leprae | Probable lipase LipE | 0.011 | 0.1327 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0194 | 0.0423 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0013 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0252 | 0.3397 | 0.92 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.08 | 0.2361 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.011 | 0.1327 | 0.1248 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0676 | 0.1471 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0143 | 0.0312 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0748 | 0.2205 |
Schistosoma mansoni | ferritin light chain | 0.0026 | 0.009 | 0.0245 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.0706 | 0.1535 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0013 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0432 | 0.1257 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.1754 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1327 | 0.3942 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0432 | 0.117 |
Trypanosoma brucei | hypothetical protein, conserved | 0.011 | 0.1327 | 0.2715 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.044 | 0.1191 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0194 | 0.0526 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0194 | 0.0544 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.155 | 0.461 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0143 | 0.0391 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0013 | 0.0035 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0458 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0738 | 0.2176 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0013 | 0.0035 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0043 | 0.0116 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.027 | 0.0586 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0143 | 0.0391 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.155 | 0.461 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0013 | 0.0035 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0013 | 0.0028 |
Loa Loa (eye worm) | beta-lactamase | 0.011 | 0.1327 | 0.3942 |
Mycobacterium tuberculosis | Conserved protein | 0.011 | 0.1327 | 0.1248 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0013 | 0.0035 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0143 | 0.0312 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0013 | 0.0028 |
Onchocerca volvulus | 0.011 | 0.1327 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.011 | 0.1327 | 0.3594 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0579 | 0.1259 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.027 | 0.0586 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.3093 |
Echinococcus granulosus | tumor protein p63 | 0.0335 | 0.4598 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0043 | 0.0093 |
Schistosoma mansoni | ferritin | 0.0026 | 0.009 | 0.0245 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0026 | 0.009 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0026 | 0.009 | 0.0196 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0013 | 0.0035 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0579 | 0.1259 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.0706 | 0.1535 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.011 | 0.1327 | 0.1248 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0077 | 0.0192 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.1831 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.011 | 0.1327 | 0.3942 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.011 | 0.1327 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.3093 |
Mycobacterium ulcerans | beta-lactamase | 0.011 | 0.1327 | 0.6529 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0271 | 0.0775 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1225 | 0.3635 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0748 | 0.2205 |
Schistosoma mansoni | apoferritin-2 | 0.0026 | 0.009 | 0.0245 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0236 | 0.0513 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.011 | 0.1327 | 0.1248 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.027 | 0.0772 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.044 | 0.1281 |
Echinococcus granulosus | lamin | 0.0029 | 0.0143 | 0.0312 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.027 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0013 | 0.0035 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0706 | 0.1911 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0013 | 0.0028 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0013 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.3346 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.044 | 0.0956 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0013 | 0.0028 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.1831 |
Mycobacterium ulcerans | hypothetical protein | 0.011 | 0.1327 | 0.6529 |
Onchocerca volvulus | 0.011 | 0.1327 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.011 | 0.1327 | 0.6529 |
Brugia malayi | beta-lactamase family protein | 0.011 | 0.1327 | 0.3942 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.155 | 0.461 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0194 | 0.0526 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0143 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0305 | 0.0878 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0013 | 0.0028 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.011 | 0.1327 | 0.6529 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0194 | 0.0526 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0194 | 0.0423 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.011 | 0.1327 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.011 | 0.1327 | 0.1248 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0143 | 0.0391 |
Mycobacterium tuberculosis | Probable hydrolase | 0.011 | 0.1327 | 0.1248 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0135 | 0.0368 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.027 | 0.073 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.044 | 0.0956 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0143 | 0.0391 |
Schistosoma mansoni | thyroid hormone receptor | 0.0273 | 0.3692 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0194 | 0.0423 |
Schistosoma mansoni | ferritin | 0.0026 | 0.009 | 0.0245 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0013 | 0.0028 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0043 | 0.0093 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0013 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1327 | 0.3942 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0013 | 0.0028 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0013 | 0.0035 |
Brugia malayi | beta-lactamase | 0.011 | 0.1327 | 0.3942 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0194 | 0.0544 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.011 | 0.1327 | 0.2886 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.0706 | 0.2078 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.0591 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0013 | 0.0035 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0013 | 0.0028 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.011 | 0.1327 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.044 | 0.1281 |
Brugia malayi | RNA binding protein | 0.0068 | 0.0706 | 0.2078 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0194 | 0.0544 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0236 | 0.0513 |
Onchocerca volvulus | 0.0051 | 0.0458 | 0.3385 | |
Schistosoma mansoni | ferritin light chain | 0.0026 | 0.009 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1327 | 0.3942 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0194 | 0.0423 |
Brugia malayi | hypothetical protein | 0.0038 | 0.027 | 0.077 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.011 | 0.1327 | 0.6529 |
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 0.4598 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0706 | 0.1911 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.1225 | 0.3635 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0013 | 0.0035 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.027 | 0.5 |
Echinococcus granulosus | ferritin | 0.0026 | 0.009 | 0.0196 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.1984 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.011 | 0.1327 | 0.2715 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0143 | 0.0312 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.1984 | 0.1911 |
Mycobacterium leprae | conserved hypothetical protein | 0.011 | 0.1327 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.2891 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.0706 | 0.2078 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0458 | 0.124 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0706 | 0.1911 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.044 | 0.0956 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0676 | 0.3093 |
Schistosoma mansoni | ferritin | 0.0026 | 0.009 | 0.0245 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0676 | 0.1471 |
Onchocerca volvulus | 0.0029 | 0.0143 | 0.0993 | |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.0631 | 0.1708 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0194 | 0.0423 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0015 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 32 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 14 days by microplate alamar blue assay | ChEMBL. | 21678907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.