Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ISWI complex protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0.0064 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0004 | 0.0082 | 0.1363 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.7379 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0003 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.4439 | 0.5 | |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.7379 | 0.7362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.1014 | 0.0453 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.4722 | 0.6015 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.4722 | 0.6015 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.7379 | 0.7362 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0711 | 0.0651 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4439 | 0.5381 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.7379 | 0.7362 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.7379 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.1014 | 0.0453 |
Plasmodium falciparum | zinc finger protein, putative | 0.0003 | 0.0064 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4439 | 0.5396 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.7379 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4722 | 0.4688 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4439 | 0.4403 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.7379 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.8876 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0603 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.7379 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0082 | 0.1363 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0191 | 0.0127 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0603 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4722 | 0.4688 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 32 nM | Agonist activity at human recombinant CB2 receptor expressed in CHO cells assessed as inhibition forskolin-induced cAMP release | ChEMBL. | 21669533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.