Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.4612 | 0.6594 |
Echinococcus granulosus | dual specificity | 0.0093 | 0.6971 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.1334 | 0.1177 |
Brugia malayi | Protein kinase domain containing protein | 0.0093 | 0.6971 | 0.6916 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4612 | 0.5816 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.4612 | 0.4515 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.1334 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0046 | 0.0046 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0093 | 0.6971 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.1334 | 0.1334 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.4612 | 0.4612 |
Echinococcus multilocularis | dual specificity | 0.0093 | 0.6971 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.6929 | 0.6929 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0093 | 0.6971 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.1334 | 0.186 |
Echinococcus multilocularis | lamin | 0.0029 | 0.1334 | 0.186 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.4612 | 0.4612 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4612 | 0.5816 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4612 | 0.5816 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.4612 | 0.4515 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.4612 | 0.6594 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.6971 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4612 | 0.5816 |
Onchocerca volvulus | Huntingtin homolog | 0.0128 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0093 | 0.6971 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0093 | 0.6971 | 0.5 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0093 | 0.6971 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0128 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0066 | 0.4612 | 0.4515 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.4612 | 0.5816 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.1334 | 0.1177 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.1334 | 0.186 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.6929 | 0.6929 |
Echinococcus granulosus | lamin | 0.0029 | 0.1334 | 0.186 |
Echinococcus multilocularis | musashi | 0.0029 | 0.1334 | 0.186 |
Entamoeba histolytica | hypothetical protein | 0.0093 | 0.6971 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1334 | 0.1334 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0093 | 0.6971 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0093 | 0.6971 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.4612 | 0.4612 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1288 | 0.1288 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.1334 | 0.186 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0093 | 0.6971 | 0.6971 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 51 uM | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay | ChEMBL. | 21632247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.