Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.014 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0422 | 0.0467 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0019 | 0.0286 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.8712 | 0.8674 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0422 | 0.014 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0422 | 0.0268 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0808 | 0.0893 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.5503 | 0.6085 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0422 | 0.014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3469 | 0.3364 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3469 | 0.3364 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0422 | 0.0268 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.4205 | 0.465 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0019 | 0.0286 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3469 | 0.3364 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0019 | 0.0286 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.4205 | 0.4112 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.8712 | 0.8674 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.677 | 0.7486 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1104 | 0.0842 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0422 | 0.0467 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0808 | 0.0537 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0019 | 0.0286 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.1104 | 0.1221 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0694 | 0.6773 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0694 | 0.6773 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0118 | 0.013 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0422 | 0.014 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0422 | 0.0268 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8712 | 0.9634 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.8712 | 0.8674 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.1104 | 0.0842 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8712 | 0.9634 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0019 | 0.0286 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0808 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0694 | 0.0768 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.014 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0019 | 0.0286 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1104 | 0.0961 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.677 | 0.7486 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0808 | 0.0893 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0019 | 0.0286 | 0.5 |
Brugia malayi | Melibiase family protein | 0.0079 | 0.4205 | 0.465 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0079 | 0.4205 | 0.4112 |
Loa Loa (eye worm) | cytochrome P450 | 0.0019 | 0.0286 | 0.0316 |
Trypanosoma brucei | cytochrome P450, putative | 0.0028 | 0.0889 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.5503 | 0.6085 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0286 | 0.0316 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0019 | 0.0286 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0422 | 0.014 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0028 | 0.0889 | 1 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0079 | 0.4205 | 1 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0808 | 0.0893 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.1104 | 0.1221 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0422 | 0.0467 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0019 | 0.0286 | 0.0193 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0422 | 0.0467 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0694 | 0.6773 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.8763 | 0.8727 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3469 | 0.3364 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0422 | 0.0467 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0808 | 0.0537 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0019 | 0.0286 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0019 | 0.0286 | 0.5 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0119 | 0.6771 | 0.6676 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3469 | 0.3364 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0019 | 0.0286 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1104 | 0.0842 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.0889 | 0.0983 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0.0286 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0019 | 0.0286 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0889 | 0.0983 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.1757 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0422 | 0.014 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0422 | 0.0268 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0422 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0422 | 0.0467 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3469 | 0.3836 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.1104 | 0.0842 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1568 | 0.132 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0808 | 0.0537 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0422 | 0.0268 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0422 | 0.0467 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0808 | 0.0537 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1568 | 0.1432 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.8712 | 0.9634 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0422 | 0.014 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0422 | 0.014 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0422 | 0.014 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0422 | 0.0467 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.1104 | 0.0842 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3469 | 0.3836 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0808 | 0.066 |
Echinococcus granulosus | lamin | 0.0027 | 0.0808 | 0.0537 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1568 | 0.132 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1104 | 0.0961 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0422 | 0.0268 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3469 | 0.3277 |
Schistosoma mansoni | cytochrome P450 | 0.0019 | 0.0286 | 0.0129 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.014 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0422 | 0.0467 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.2001 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0154 | 0.9043 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1104 | 0.1221 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3469 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0422 | 0.0268 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.6771 | 0.6719 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0694 | 0.0768 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | acetyltransferase | 0.0154 | 0.9043 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.1757 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.677 | 0.7486 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0019 | 0.0286 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0422 | 0.0268 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0422 | 0.014 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.1757 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0028 | 0.0889 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0.0286 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0808 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3469 | 0.3277 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0422 | 0.0268 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0021 | 0.0422 | 0.014 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0119 | 0.6771 | 0.6676 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0019 | 0.0286 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | thyroid hormone receptor | 0.0021 | 0.0422 | 0.0268 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.1104 | 0.0842 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.1104 | 0.1221 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.3467 | 0.3361 |
Schistosoma mansoni | lamin | 0.0027 | 0.0808 | 0.066 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.5503 | 0.6085 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0422 | 0.0467 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0422 | 0.014 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0422 | 0.0467 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0154 | 0.9043 | 0.9015 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.0889 | 0.0983 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0019 | 0.0286 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3467 | 0.3833 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0776 | 0.0858 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.5503 | 0.6085 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0019 | 0.0286 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.6771 | 0.6719 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0889 | 0.0983 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0286 | 0.0129 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0422 | 0.0467 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0422 | 0.0467 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0028 | 0.0889 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0694 | 0.6773 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.6771 | 0.6719 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0019 | 0.0286 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0019 | 0.0286 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0422 | 0.014 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3469 | 0.3836 |
Schistosoma mansoni | lamin | 0.0027 | 0.0808 | 0.066 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0422 | 0.0268 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0808 | 0.0537 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0694 | 0.081 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0119 | 0.6771 | 0.6676 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0422 | 0.014 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3469 | 0.3836 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0422 | 0.0467 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0019 | 0.0286 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3469 | 0.3836 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0422 | 0.0467 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0808 | 0.0893 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.2912 | 0.322 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1568 | 0.1733 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.3467 | 0.3833 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.2001 | 0.2787 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0028 | 0.0889 | 0.0983 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0422 | 0.014 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0119 | 0.6771 | 0.6719 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0422 | 0.0467 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0422 | 0.0268 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1104 | 0.0961 |
Brugia malayi | cytochrome P450 | 0.0019 | 0.0286 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0422 | 0.0467 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.2001 | 0.1766 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0422 | 0.0467 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0422 | 0.0467 |
Onchocerca volvulus | 0.0027 | 0.0808 | 1 | |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.2912 | 0.322 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0154 | 0.9043 | 0.9028 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1568 | 0.1432 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0422 | 0.0268 |
Toxoplasma gondii | melibiase subfamily protein | 0.0119 | 0.6771 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1104 | 0.0961 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.2001 | 0.2787 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0019 | 0.0286 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0028 | 0.0889 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.