Detailed information for compound 108223

Basic information

Technical information
  • TDR Targets ID: 108223
  • Name: N-(2-chloroanilino)-N'-(3-chlorophenyl)-2-oxo propanimidamide
  • MW: 322.189 | Formula: C15H13Cl2N3O
  • H donors: 2 H acceptors: 1 LogP: 4.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)N/C(=N/Nc1ccccc1Cl)/C(=O)C
  • InChi: 1S/C15H13Cl2N3O/c1-10(21)15(18-12-6-4-5-11(16)9-12)20-19-14-8-3-2-7-13(14)17/h2-9,19H,1H3,(H,18,20)
  • InChiKey: UPDIANIMXSDAJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chloroanilino)-N'-(3-chlorophenyl)-2-oxo-propanamidine
  • N-(2-chloroanilino)-N'-(3-chlorophenyl)-2-oxopropanamidine
  • N'-(3-chlorophenyl)-N-[(2-chlorophenyl)amino]-2-oxo-propanimidamide
  • N-(2-chloroanilino)-N'-(3-chlorophenyl)-2-keto-propionamidine
  • N'-(3-chlorophenyl)-N-[(2-chlorophenyl)amino]-2-oxopropanimidamide
  • N'-(3-chlorophenyl)-N-[(2-chlorophenyl)amino]-2-oxo-propanamidine
  • N'-(3-chlorophenyl)-N-[(2-chlorophenyl)amino]-2-oxopropanamidine
  • N'-(3-chlorophenyl)-N-[(2-chlorophenyl)amino]-2-keto-propionamidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens corticotropin releasing hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 1 444 aa 445 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0763 0.0697
Leishmania major proteasome beta-1 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0035 0.0364 0.0294
Toxoplasma gondii proteasome subunit alpha type, putative 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0035 0.0364 0.0294
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0035 0.0364 0.0294
Toxoplasma gondii peptidase, T1 family protein 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit beta type 2 0.0035 0.0364 0.0364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0222 0.4608 0.4569
Brugia malayi Proteasome subunit alpha type 7-1 0.0035 0.0364 0.0364
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.02 0.4109 0.4067
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0418 0.0418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0763 0.0697
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0035 0.0364 0.0294
Leishmania major proteasome alpha 1 subunit, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome subunit beta type 2 0.0035 0.0364 0.0294
Loa Loa (eye worm) hypothetical protein 0.0302 0.6422 0.6396
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.0037 0.0418 0.0349
Trypanosoma brucei proteasome alpha 7 subunit 0.0035 0.0364 0.0294
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0035 0.0364 0.0294
Leishmania major proteasome beta 2 subunit, putative 0.0035 0.0364 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0231 0.0161
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.1392 0.1392
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0461 1 1
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.008 0.1392 0.133
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0035 0.0364 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0364 0.0294
Toxoplasma gondii proteasome subunit beta type, putative 0.0461 1 1
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0035 0.0364 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0035 0.0364 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit alpha type 4 0.0035 0.0364 0.0364
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0231 0.0161
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0035 0.0364 0.0294
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0035 0.0364 0.0294
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0231 0.0161
Schistosoma mansoni gamma-secretase subunit aph-1 0.0258 0.5414 0.5381
Loa Loa (eye worm) hypothetical protein 0.0037 0.0418 0.0349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0418 0.0349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0763 0.0697
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0418 0.0349
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0461 1 1
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0461 1 1
Brugia malayi Proteasome subunit alpha type 1 0.0035 0.0364 0.0364
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0035 0.0364 0.0294
Onchocerca volvulus Notchless protein homolog 0.0035 0.0364 1
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit beta type-5, putative 0.0461 1 1
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome subunit alpha type 6 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome beta 6 subunit 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0035 0.0364 0.0294
Toxoplasma gondii proteasome subunit alpha1, putative 0.0035 0.0364 0.0294
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome prosome macropain 0.0461 1 1
Echinococcus multilocularis proteasome subunit beta type 6 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Echinococcus multilocularis gamma secretase subunit aph 1 0.0258 0.5414 0.5381
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0231 0.0161
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0035 0.0364 0.0294
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0461 1 1
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0035 0.0364 0.0294
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0222 0.4608 0.4569
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0035 0.0364 0.0294
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi 20S proteasome subunit 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0035 0.0364 0.0294
Toxoplasma gondii heat shock protein hslv, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0461 1 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0461 1 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0035 0.0364 0.0294
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome subunit beta type 3 0.0035 0.0364 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0035 0.0364 0.0294
Brugia malayi Cathepsin L-like precursor 0.0022 0.0072 0.0072
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.0037 0.0418 0.0349
Leishmania major proteasome beta 7 subunit, putative 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.2232 0.2176
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0035 0.0364 0.0294
Leishmania major proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit alpha type 1 0.0035 0.0364 0.0364
Leishmania major proteasome beta 2 subunit, putative 0.0035 0.0364 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0364 0.0294
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0035 0.0364 0.5
Leishmania major proteasome alpha 3 subunit, putative 0.0035 0.0364 0.0294
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit beta type-4, putative 0.0035 0.0364 0.0294
Echinococcus multilocularis proteasome subunit alpha type 2 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0231 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0763 0.0697
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0461 1 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0035 0.0364 0.0294
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0763 0.0763
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0763 0.0697
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0035 0.0364 0.0294
Echinococcus multilocularis proteasome subunit alpha type 6 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0035 0.0364 0.0294
Brugia malayi Proteasome A-type and B-type family protein 0.0035 0.0364 0.0364
Brugia malayi Proteasome A-type and B-type family protein 0.0035 0.0364 0.0364
Leishmania major proteasome alpha 1 subunit, putative 0.0035 0.0364 0.0294
Mycobacterium ulcerans proteasome PrcB 0.0461 1 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit beta type 1 0.0035 0.0364 0.0364
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0035 0.0364 0.0294
Echinococcus granulosus geminin 0.02 0.4109 0.4067
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0461 1 1
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.1853 0.1794
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0461 1 1
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0035 0.0364 0.0294
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0418 0.0418
Leishmania major hypothetical protein, conserved 0.0029 0.0231 0.0161
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit alpha type 3 0.0035 0.0364 0.0364
Brugia malayi Cathepsin L-like precursor 0.0022 0.0072 0.0072
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0763 0.0697
Brugia malayi Cathepsin L-like precursor 0.0022 0.0072 0.0072
Plasmodium vivax proteasome subunit beta type-2, putative 0.0035 0.0364 0.0294
Brugia malayi Cathepsin L-like precursor 0.0022 0.0072 0.0072
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.0037 0.0418 0.0349
Toxoplasma gondii proteasome beta subunit 0.0035 0.0364 0.0294
Echinococcus multilocularis proteasome subunit beta type 7 0.0035 0.0364 0.0294
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0258 0.5414 0.5381
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0035 0.0364 0.0294
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.2232 0.2232
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0035 0.0364 0.0294
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0461 1 1
Plasmodium falciparum proteasome subunit beta type-5 0.0461 1 1
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) PAS-3 protein 0.0035 0.0364 0.0294
Echinococcus multilocularis GPCR, family 2 0.0037 0.0418 0.0349
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit alpha type 6 0.0035 0.0364 0.0364
Trypanosoma brucei proteasome beta 7 subunit 0.0035 0.0364 0.0294
Loa Loa (eye worm) hypothetical protein 0.0029 0.0231 0.0161
Brugia malayi 20S proteasome alpha5 subunit 0.0035 0.0364 0.0364
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome subunit beta type 6 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0035 0.0364 0.0294
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0035 0.0364 0.0294
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.02 0.4109 0.4067
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0035 0.0364 0.0294
Leishmania major proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0035 0.0364 0.0294
Brugia malayi Cathepsin L-like precursor 0.0022 0.0072 0.0072
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit beta type-4 0.0035 0.0364 0.0294
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0035 0.0364 0.0294
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit beta type-6, putative 0.0035 0.0364 0.0294
Brugia malayi gamma-secretase subunit aph-1 0.0258 0.5414 0.5414
Loa Loa (eye worm) hypothetical protein 0.008 0.1392 0.133
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0072 0.0072
Brugia malayi Cathepsin L-like precursor 0.0022 0.0072 0.0072
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0035 0.0364 0.0294
Leishmania major proteasome alpha 2 subunit, putative 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0035 0.0364 0.0294
Toxoplasma gondii proteasome subunit 0.0035 0.0364 0.0294
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0035 0.0364 0.0294
Echinococcus granulosus GPCR family 2 0.0037 0.0418 0.0349
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0035 0.0364 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0231 0.0161
Leishmania major proteasome beta 5 subunit, putative 0.0461 1 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0258 0.5414 0.5381
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0035 0.0364 0.0294
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit beta type-7, putative 0.0035 0.0364 0.0294
Leishmania major proteasome beta 3 subunit, putative 0.0035 0.0364 0.0294
Echinococcus granulosus subfamily T1A non peptidase ue 0.0035 0.0364 0.0294
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0035 0.0364 0.0294
Brugia malayi proteasome subunit alpha type 2 0.0035 0.0364 0.0364
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0035 0.0364 0.0294
Brugia malayi hypothetical protein 0.0029 0.0231 0.0231
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0035 0.0364 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0763 0.0697
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0035 0.0364 0.0294
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0035 0.0364 0.0294
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0035 0.0364 0.0294
Echinococcus multilocularis geminin 0.02 0.4109 0.4067
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0035 0.0364 0.0294
Schistosoma mansoni hypothetical protein 0.0037 0.0418 0.0349
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0231 0.0161
Brugia malayi Proteasome A-type and B-type family protein 0.0035 0.0364 0.0364
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0035 0.0364 0.0294
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0035 0.0364 0.0294
Trypanosoma brucei Aph-1 protein, putative 0.01 0.1853 0.1794
Echinococcus granulosus proteasome subunit beta type 7 0.0035 0.0364 0.0294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0763 0.0697
Brugia malayi proteasome subunit beta type 3 0.0035 0.0364 0.0364
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome subunit beta t family 0.0035 0.0364 0.0294
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0035 0.0364 0.0294
Echinococcus granulosus proteasome subunit alpha type 2 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0035 0.0364 0.0294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.6422 0.6422
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0035 0.0364 0.0294
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0035 0.0364 0.0294
Echinococcus granulosus Proteasome subunit alpha beta 0.0035 0.0364 0.0294
Echinococcus granulosus Proteasome subunit alpha type 7 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi Aph-1 protein, putative 0.01 0.1853 0.1794
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0035 0.0364 0.0294
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0461 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0418 0.0349
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0035 0.0364 0.0294
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0035 0.0364 0.0294
Loa Loa (eye worm) proteasome subunit beta type 1 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit beta type-3, putative 0.0035 0.0364 0.0294
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0035 0.0364 0.0294
Plasmodium vivax proteasome subunit beta type-1, putative 0.0035 0.0364 0.0294

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 417 nM Binding affinity against human Corticotropin releasing factor receptor 1 ChEMBL. 12014949
Ki (binding) = 417 nM Binding affinity against human Corticotropin releasing factor receptor 1 ChEMBL. 12014949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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