Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0026 | 0.1071 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3341 | 0.3341 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.3341 | 0.3341 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1071 | 0.0878 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0407 | 0.0407 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0407 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0212 | 0.0212 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0407 | 0.0199 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0407 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.1071 | 0.0878 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0407 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1071 | 0.0878 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0407 | 0.0199 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0407 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0407 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0407 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0407 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0407 | 0.0407 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0407 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0212 | 0.0212 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0407 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0407 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.1071 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1029 | 0.1029 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.3341 | 0.3341 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1071 | 0.1071 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1071 | 0.0878 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0407 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1071 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1071 | 0.1071 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1071 | 0.1071 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0407 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0407 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1893 | 0.1717 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1893 | 0.1893 |
Echinococcus granulosus | lamin | 0.0026 | 0.1071 | 0.0878 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0407 | 0.0199 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1071 | 0.0878 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1893 | 0.1893 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.3341 | 0.3341 |
Brugia malayi | TAR-binding protein | 0.0127 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0407 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.1071 | 0.5 | |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0407 | 0.0199 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0212 | 0.0212 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1071 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1071 | 0.1071 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0407 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.