Detailed information for compound 1082491

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 266.702 | Formula: C12H12ClFN4
  • H donors: 0 H acceptors: 3 LogP: 3.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1nc(Cl)c2c(n1)n(cn2)[C@@H]1C[C@@H]2C[C@H]1CC2
  • InChi: 1S/C12H12ClFN4/c13-10-9-11(17-12(14)16-10)18(5-15-9)8-4-6-1-2-7(8)3-6/h5-8H,1-4H2/t6-,7+,8+/m0/s1
  • InChiKey: USFGOFMRUPXRQP-XLPZGREQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Schistosoma mansoni peroxidasin 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Onchocerca volvulus Peroxidasin homolog 0.0027 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptide receptor 0.0009 0.0298 0.0298
Brugia malayi larval opioid receptor 0.0009 0.0298 0.0298
Brugia malayi Blistered cuticle protein 3 0.0027 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Echinococcus granulosus g protein coupled receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis somatostatin receptor 0.0009 0.0298 0.0298
Brugia malayi Serotonin receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0298 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0298 0.0298
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0298 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0298 0.0298
Onchocerca volvulus Peroxidasin homolog 0.0027 1 1
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0298 0.0298
Brugia malayi neuropeptide F receptor 0.0009 0.0298 0.0298
Brugia malayi sulfakinin receptor protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) animal heme peroxidase 0.0027 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0298 0.0298
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0298 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus granulosus sex peptide receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi ORL1-like opioid receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0298 0.0298
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0298 0.0298
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0298 0.0298
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0298 0.0298
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Brugia malayi Animal haem peroxidase family protein 0.0027 1 1
Brugia malayi G protein-coupled receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0298 0.0298
Onchocerca volvulus Peroxidase homolog 0.0027 1 1
Echinococcus multilocularis peroxidasin 0.0027 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0298 0.0298
Echinococcus multilocularis serotonin receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0298 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0298 0.0298
Brugia malayi Dopamine receptor 0.0009 0.0298 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0298 0.0298
Brugia malayi G-protein coupled receptor 0.0009 0.0298 0.0298
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi G-protein coupled receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0298 0.0298
Echinococcus multilocularis sex peptide receptor 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0298 0.0298
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus Dual oxidase homolog 0.0027 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0298 0.0298
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0298 0.0298
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0298 0.0298
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0298 0.0298
Brugia malayi Dopamine receptor protein 1 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Brugia malayi Animal haem peroxidase family protein 0.0027 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0298 0.0298
Echinococcus granulosus orexin receptor type 2 0.0009 0.0298 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0027 1 1
Brugia malayi GnHR receptor homolog 0.0009 0.0298 0.0298
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0298 0.0298
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0298 0.0298
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0298 0.0298
Brugia malayi neuropeptide F receptor 0.0009 0.0298 0.0298
Brugia malayi Serotonin receptor 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus granulosus somatostatin receptor 0.0009 0.0298 0.0298
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0298 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0298 0.0298
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi RE15519p 0.0009 0.0298 0.0298
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0298 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptide receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0298 0.0298
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0298 0.0298
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi AKH receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0027 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus granulosus fmrfamide receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Loa Loa (eye worm) animal heme peroxidase 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus granulosus g protein coupled receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis serotonin receptor 0.0009 0.0298 0.0298
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0298 0.0298
Onchocerca volvulus Peroxidase homolog 0.0027 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Brugia malayi Animal haem peroxidase family protein 0.0027 1 1
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi Peroxidasin 0.0027 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi Dopamine receptor protein 2 0.0009 0.0298 0.0298
Echinococcus granulosus peroxidasin 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0298 0.0298
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0298 0.0298
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Echinococcus granulosus serotonin receptor 0.0009 0.0298 0.0298
Brugia malayi putative neuropeptide receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Echinococcus granulosus allatostatin A receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Schistosoma mansoni peroxidasin 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0298 0.0298
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0298 0.0298
Loa Loa (eye worm) animal heme peroxidase 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Loa Loa (eye worm) animal heme peroxidase 0.0027 1 1
Brugia malayi hypothetical protein 0.0009 0.0298 0.0298
Onchocerca volvulus 0.0009 0.0298 0.0298
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0298 0.0298
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0298 0.0298
Echinococcus granulosus g protein coupled receptor 0.0009 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0009 0.0298 0.0298
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0298 0.0298
Brugia malayi Melatonin receptor type 1A 0.0009 0.0298 0.0298
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0298 0.0298
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0298 0.0298

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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