Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4C, cAMP-specific | References | |
Homo sapiens | phosphodiesterase 4B, cAMP-specific | References | |
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 4A, cAMP-specific | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.7187 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0767 | 0.097 | 0.0957 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0447 | 0.0519 | 0.0932 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3709 | 0.5107 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0447 | 0.0519 | 0.0505 |
Echinococcus multilocularis | pyruvate kinase | 0.0111 | 0.0047 | 0.0033 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0767 | 0.097 | 0.0927 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0447 | 0.0519 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | pyruvate kinase | 0.0111 | 0.0047 | 0.0047 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7187 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3709 | 0.5107 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.7187 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0392 | 0.0442 | 0.0397 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7187 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3709 | 0.5107 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3709 | 0.5107 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7187 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0078 | 0 | 0.5 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0447 | 0.0519 | 0.0474 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0447 | 0.0519 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0767 | 0.097 | 0.097 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0447 | 0.0519 | 0.0505 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0767 | 0.097 | 0.0927 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0767 | 0.097 | 0.0927 |
Loa Loa (eye worm) | pyruvate kinase | 0.0111 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0392 | 0.0442 | 0.0442 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3709 | 0.5107 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0392 | 0.0442 | 0.0429 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7187 | 1 | 1 |
Onchocerca volvulus | 0.0767 | 0.097 | 1 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0365 | 0.0404 | 0.0706 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0447 | 0.0519 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | pyruvate kinase | 0.0111 | 0.0047 | 0.0047 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3709 | 0.5107 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0392 | 0.0442 | 0.0397 |
Echinococcus granulosus | thymidylate synthase | 0.0767 | 0.097 | 0.0927 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0365 | 0.0404 | 1 |
Brugia malayi | thymidylate synthase | 0.0767 | 0.097 | 0.0927 |
Echinococcus multilocularis | pyruvate kinase | 0.0111 | 0.0047 | 0.0033 |
Mycobacterium ulcerans | thymidylate synthase | 0.0767 | 0.097 | 0.0927 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7187 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.7187 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0365 | 0.0404 | 0.0359 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7187 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0365 | 0.0404 | 0.0359 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 60 nM | In vitro inhibitory activity against platelet phosphodiesterase (PDE) | ChEMBL. | 2846840 |
IC50 (binding) | = 60 nM | In vitro inhibitory activity against platelet phosphodiesterase (PDE) | ChEMBL. | 2846840 |
Max CF response (functional) | 0 % | In vivo inotropic activity in canine model by intravenous administration (Inactive) | ChEMBL. | 2846840 |
Max CF response (functional) | 0 % | In vivo inotropic activity in canine model by intraduodenal administration (Inactive) | ChEMBL. | 2846840 |
T1/2 (ADMET) | = 20 day | Half life after consumption of the drug | ChEMBL. | 2846840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.