Detailed information for compound 1082647

Basic information

Technical information
  • TDR Targets ID: 1082647
  • Name: 3,4-bis(1H-indol-3-yl)-5-methoxycarbonyl-1H-p yrrole-2-carboxylic acid
  • MW: 399.399 | Formula: C23H17N3O4
  • H donors: 4 H acceptors: 3 LogP: 4.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1[nH]c(c(c1c1c[nH]c2c1cccc2)c1c[nH]c2c1cccc2)C(=O)O
  • InChi: 1S/C23H17N3O4/c1-30-23(29)21-19(15-11-25-17-9-5-3-7-13(15)17)18(20(26-21)22(27)28)14-10-24-16-8-4-2-6-12(14)16/h2-11,24-26H,1H3,(H,27,28)
  • InChiKey: CUKHLCPFGKVMHR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-carbomethoxy-3,4-bis(1H-indol-3-yl)-1H-pyrrole-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0071 0.0566 0.075
Loa Loa (eye worm) hypothetical protein 0.0097 0.0857 0.127
Schistosoma mansoni hypothetical protein 0.0283 0.3001 0.4986
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 1
Entamoeba histolytica hypothetical protein 0.0071 0.0564 0.6482
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0566 0.8854
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0278 0.0388
Trichomonas vaginalis esterase, putative 0.0071 0.0566 0.2281
Trypanosoma brucei unspecified product 0.006 0.0438 0.3958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1474 0.2448
Entamoeba histolytica hypothetical protein 0.0071 0.0564 0.6482
Loa Loa (eye worm) hypothetical protein 0.0204 0.2101 0.3164
Leishmania major DNA polymerase eta, putative 0.0115 0.107 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0566 0.094
Loa Loa (eye worm) hypothetical protein 0.007 0.0554 0.0809
Schistosoma mansoni tar DNA-binding protein 0.0267 0.2824 0.469
Echinococcus multilocularis protein dispatched 1 0.0047 0.0288 0.0288
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0267 0.2824 0.4265
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.028 0.4215
Loa Loa (eye worm) MBCTL1 0.0053 0.0353 0.0501
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.0438 0.4967
Brugia malayi Ets-domain containing protein 0.0082 0.0692 0.1019
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0566 0.2281
Schistosoma mansoni ran 0.0024 0.0024 0.0039
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0074 0.059 0.9298
Loa Loa (eye worm) hypothetical protein 0.0071 0.0566 0.0826
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 1
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0438 0.3958
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0488 0.0488
Schistosoma mansoni hypothetical protein 0.0071 0.0564 0.0937
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0317 0.2804
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.1855 0.3081
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0566 0.5185
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1765 0.2932
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0566 0.6572
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.2101 0.3164
Echinococcus granulosus expressed conserved protein 0.0091 0.079 0.1312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0052 0.012
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0052 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1474 0.2448
Brugia malayi RNA recognition motif domain containing protein 0.0267 0.2824 0.4265
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0222 0.1895
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.0438 0.0631
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0566 0.0513
Schistosoma mansoni hypothetical protein 0.004 0.0204 0.0338
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0317 0.4814
Loa Loa (eye worm) hypothetical protein 0.0044 0.0249 0.0343
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0278 0.0462
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0488 0.0708
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0438 0.3958
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0566 0.0513
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.0356 0.5454
Echinococcus multilocularis geminin 0.0544 0.602 0.602
Echinococcus multilocularis dna polymerase eta 0.0115 0.107 0.107
Mycobacterium tuberculosis Conserved protein 0.0071 0.0566 0.0513
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0146 0.0243
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0566 0.0513
Brugia malayi Importin beta-1 subunit 0.0033 0.0125 0.0154
Onchocerca volvulus 0.0231 0.2402 0.357
Toxoplasma gondii ABC1 family protein 0.0071 0.0566 0.8902
Schistosoma mansoni zinc finger protein 0.0023 0.0011 0.0019
Plasmodium vivax SET domain protein, putative 0.0029 0.0077 0.0882
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.129 0.1928
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0566 0.2281
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2402 1
Leishmania major hypothetical protein, conserved 0.0071 0.0566 0.5185
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0354 0.3824 0.5788
Giardia lamblia DINP protein human, muc B family 0.006 0.0438 1
Schistosoma mansoni DNA polymerase eta 0.0115 0.107 0.1777
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0566 0.094
Brugia malayi Bromodomain containing protein 0.0042 0.0222 0.0302
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1765 0.1765
Echinococcus multilocularis dna polymerase kappa 0.006 0.0438 0.0438
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.0438 0.0727
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0438 0.3958
Brugia malayi beta-lactamase 0.0071 0.0566 0.0826
Schistosoma mansoni tar DNA-binding protein 0.0267 0.2824 0.469
Schistosoma mansoni hypothetical protein 0.0354 0.3824 0.6351
Leishmania major DNA polymerase kappa, putative 0.006 0.0438 0.3958
Brugia malayi RNA binding protein 0.0267 0.2824 0.4265
Onchocerca volvulus 0.0046 0.0278 0.0309
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0488 0.0708
Brugia malayi hypothetical protein 0.0594 0.6588 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 0.5
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0633 0.1051
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0633 0.0633
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.0356 0.5454
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0566 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Entamoeba histolytica hypothetical protein 0.0071 0.0564 0.6482
Schistosoma mansoni hypothetical protein 0.0065 0.0488 0.0811
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0633 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0438 0.3958
Onchocerca volvulus 0.0594 0.6588 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0566 0.6572
Entamoeba histolytica hypothetical protein 0.0071 0.0564 0.6482
Schistosoma mansoni hypothetical protein 0.014 0.1354 0.225
Loa Loa (eye worm) hypothetical protein 0.0071 0.0566 0.0826
Loa Loa (eye worm) hypothetical protein 0.0291 0.3099 0.4684
Echinococcus multilocularis snurportin 1 0.0354 0.3824 0.3824
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0278 0.0462
Brugia malayi Ets-domain containing protein 0.0082 0.0692 0.1019
Leishmania major DNA polymerase eta, putative 0.0074 0.059 0.5415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1474 0.2448
Schistosoma mansoni importin beta-1 0.0033 0.0125 0.0207
Mycobacterium ulcerans hypothetical protein 0.0071 0.0566 0.6572
Schistosoma mansoni bromodomain containing protein 0.0066 0.0502 0.0835
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.0438 0.0438
Schistosoma mansoni hypothetical protein 0.0544 0.602 1
Echinococcus multilocularis GPCR, family 2 0.0065 0.0488 0.0488
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1765 0.2653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0269 0.0447
Schistosoma mansoni ran 0.0024 0.0024 0.0039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0052 0.0274
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.0356 0.1398
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0353 0.0586
Echinococcus multilocularis expressed conserved protein 0.0091 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0154
Loa Loa (eye worm) hypothetical protein 0.005 0.0317 0.0447
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0077 0.0882
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0566 0.0513
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0278 0.0278
Schistosoma mansoni hypothetical protein 0.0065 0.0488 0.0811
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0438 0.0239
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0221 0.03
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0317 0.4814
Schistosoma mansoni tar DNA-binding protein 0.0267 0.2824 0.469
Brugia malayi beta-lactamase family protein 0.0071 0.0566 0.0826
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 0.5
Echinococcus multilocularis zinc finger protein 0.0023 0.0011 0.0011
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0326 0.0326
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.1474 0.2209
Brugia malayi beta-lactamase family protein 0.0071 0.0566 0.0826
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0077 0.0077
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0221 0.0367
Mycobacterium tuberculosis Conserved protein 0.0071 0.0566 0.0513
Onchocerca volvulus 0.0071 0.0566 0.075
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.059 0.5415
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0438 0.0631
Mycobacterium tuberculosis Conserved protein 0.0071 0.0566 0.0513
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0566 0.0513
Loa Loa (eye worm) hypothetical protein 0.0071 0.0566 0.0826
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0438 0.3958
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Trypanosoma brucei DNA polymerase eta, putative 0.0115 0.107 1
Brugia malayi Muscleblind-like protein 0.0291 0.3099 0.4684
Echinococcus granulosus snurportin 1 0.0354 0.3824 0.6351
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0065 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0278 0.0309
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.0438 0.0727
Brugia malayi CHE-14 protein 0.0041 0.0221 0.03
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0024 0.0024
Brugia malayi RNA, U transporter 1 0.0094 0.0829 0.1227
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0488 0.0811
Schistosoma mansoni hypothetical protein 0.0065 0.0488 0.0811
Trypanosoma brucei unspecified product 0.0042 0.0222 0.1895
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1474 0.1474
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0317 0.2804
Plasmodium vivax importin-beta 2, putative 0.0033 0.0125 0.1657
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0326 0.4744
Echinococcus multilocularis muscleblind protein 1 0.0291 0.3099 0.3099
Brugia malayi Fli-1 protein 0.025 0.2626 0.3965
Schistosoma mansoni hypothetical protein 0.0544 0.602 1
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0692 0.115
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0326 0.0542
Brugia malayi TAR-binding protein 0.0267 0.2824 0.4265
Leishmania major importin beta-1 subunit, putative 0.0027 0.0052 0.0274
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0438 0.3958
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1336 0.2219
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0633 1
Echinococcus granulosus dna polymerase kappa 0.006 0.0438 0.0727
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0564 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0269 0.0447
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0278 0.0462
Echinococcus granulosus geminin 0.0544 0.602 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0566 0.8902
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.028 0.6202
Loa Loa (eye worm) hypothetical protein 0.0046 0.0278 0.0388
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0221 0.0367
Leishmania major hypothetical protein, conserved 0.005 0.0317 0.2804
Loa Loa (eye worm) hypothetical protein 0.0071 0.0566 0.0826
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0633 0.1051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2079 0.313
Schistosoma mansoni patched 1 0.0041 0.0221 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Mycobacterium ulcerans lipase LipD 0.0071 0.0566 0.6572
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0077 0.0129
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.2101 0.3164
Echinococcus multilocularis protein patched 0.0041 0.0221 0.0221
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0692 0.0692
Schistosoma mansoni tar DNA-binding protein 0.0267 0.2824 0.469
Brugia malayi MH2 domain containing protein 0.0134 0.129 0.1928
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0566 0.094
Loa Loa (eye worm) hypothetical protein 0.0046 0.0271 0.0376
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0857 0.1424
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0353 0.0353
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0566 0.2281
Echinococcus granulosus GPCR family 2 0.0065 0.0488 0.0811
Brugia malayi Probable ClpP-like protease 0.0077 0.0633 0.0928
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1336 0.1336
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0633 1
Brugia malayi mbt repeat family protein 0.0046 0.0278 0.0388
Loa Loa (eye worm) hypothetical protein 0.0065 0.0488 0.0708
Trypanosoma brucei unspecified product 0.0042 0.0222 0.1895
Brugia malayi PHD-finger family protein 0.0029 0.0071 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0438 0.3958
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0278 0.0278
Onchocerca volvulus 0.0071 0.0566 0.075
Brugia malayi mbt repeat family protein 0.0046 0.0278 0.0388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0168 0.1683 0.2795
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0564 0.0937
Loa Loa (eye worm) hypothetical protein 0.0291 0.3099 0.4684
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0438 0.3958
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0024 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.5005 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0566 0.0513
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.107 0.1594
Trypanosoma cruzi DNA polymerase eta, putative 0.0115 0.107 1
Echinococcus multilocularis tar DNA binding protein 0.0267 0.2824 0.2824
Schistosoma mansoni hypothetical protein 0.0065 0.0488 0.0811
Loa Loa (eye worm) RNA binding protein 0.0267 0.2824 0.4265
Toxoplasma gondii hypothetical protein 0.0027 0.0049 0.0418
Echinococcus granulosus dna polymerase eta 0.0115 0.107 0.1777
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0462 0.0768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1474 0.2448
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.0356 0.5454
Loa Loa (eye worm) hypothetical protein 0.0077 0.0633 0.0928
Mycobacterium leprae Probable lipase LipE 0.0071 0.0566 0.8854
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.03
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0125 0.1657
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.1855 0.1855
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0222 0.1895
Brugia malayi hypothetical protein 0.005 0.0317 0.0447
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0049 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1474 0.2448
Loa Loa (eye worm) hypothetical protein 0.0069 0.0537 0.0782
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.0438 0.0727
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.0356 0.0591
Schistosoma mansoni hypothetical protein 0.004 0.0204 0.0338
Loa Loa (eye worm) TAR-binding protein 0.0267 0.2824 0.4265
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0438 0.0239
Brugia malayi Pre-SET motif family protein 0.0029 0.0077 0.0082
Brugia malayi Bromodomain containing protein 0.0077 0.0634 0.093
Brugia malayi Pre-SET motif family protein 0.0203 0.2079 0.313
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0566 0.5185
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0071 0.0566 0.0826
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0692 0.1019
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0222 0.1895
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0317 0.4814
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1354 0.2027
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Loa Loa (eye worm) hypothetical protein 0.0051 0.0328 0.0464
Brugia malayi hypothetical protein 0.0071 0.0564 0.0823
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0488 0.0488
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0049 0.0418
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0633 1
Schistosoma mansoni tar DNA-binding protein 0.0267 0.2824 0.469
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0278 0.0462
Loa Loa (eye worm) hypothetical protein 0.0594 0.6588 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.0566 0.6572
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0353 0.0353
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0125 0.0965
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0269 0.0447
Brugia malayi hypothetical protein 0.0032 0.0113 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1474 0.1474
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0566 0.0513
Echinococcus granulosus importin subunit beta 1 0.0033 0.0125 0.0207
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0353 0.0501
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0566 0.0826
Schistosoma mansoni gabp alpha 0.0082 0.0692 0.115
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.0356 0.1398
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0221 0.0829
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0221 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.2101 0.3164
Echinococcus granulosus tar DNA binding protein 0.0267 0.2824 0.469
Echinococcus granulosus zinc finger protein 0.0023 0.0011 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0146 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0317 0.2804
Loa Loa (eye worm) hypothetical protein 0.0071 0.0566 0.0826
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0566 0.2281
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0438 0.1742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0077 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0438 0.3958
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0353 0.0586
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0278 0.0462
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0317 0.4814
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0125 0.0125
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0564 0.0937
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0353 0.0586
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0566 0.0826
Echinococcus multilocularis muscleblind protein 0.0291 0.3099 0.3099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.1474 0.2209
Schistosoma mansoni ets-related 0.025 0.2626 0.4363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0174 0.0228
Loa Loa (eye worm) hypothetical protein 0.014 0.1354 0.2027
Loa Loa (eye worm) beta-lactamase 0.0071 0.0566 0.0826
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0857 1
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0566 0.5185
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0125 0.0965
Entamoeba histolytica hypothetical protein 0.0027 0.0052 0.0343
Loa Loa (eye worm) hypothetical protein 0.0053 0.0353 0.0501
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0488 0.0811
Schistosoma mansoni hypothetical protein 0.004 0.0204 0.0338
Schistosoma mansoni hypothetical protein 0.004 0.0204 0.0338
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0438 0.1742
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0875 0.1453
Echinococcus granulosus muscleblind protein 0.0291 0.3099 0.5147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0488 0.0708
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0566 0.2281
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0857 0.127
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0269 0.0269
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0857 0.0857
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.129 0.1928
Loa Loa (eye worm) acetyltransferase 0.0175 0.1765 0.2653
Loa Loa (eye worm) fli-1 protein 0.025 0.2626 0.3965
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0633 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.107 0.1594
Plasmodium falciparum importin beta, putative 0.0033 0.0125 0.1657
Loa Loa (eye worm) hypothetical protein 0.0046 0.0269 0.0374
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.028 0.308
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0052 0.012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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