Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.6378 | 0.8342 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.1269 | 0.1547 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.3156 | 0.3848 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1292 | 0.1575 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1292 | 0.1575 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5876 | 0.7163 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.8203 | 1 |
Leishmania major | trypanothione reductase | 0.0046 | 0.1269 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.1269 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.6378 | 0.8342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1292 | 0.1575 |
Brugia malayi | glutathione reductase | 0.0046 | 0.1269 | 0.1547 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5876 | 0.7163 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.1269 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1292 | 0.1292 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.7394 | 1 |
Brugia malayi | RNA binding protein | 0.0127 | 0.8203 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.1269 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.7394 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5876 | 0.7163 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.3156 | 0.3156 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.1269 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.6378 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.6378 | 0.8342 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.6378 | 0.8342 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1292 | 0.1575 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.1269 | 0.1547 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8203 | 0.8203 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.1269 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1292 | 0.1575 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.1269 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8203 | 0.8203 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.8203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3156 | 0.3848 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.8203 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5876 | 0.7163 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.7394 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.7394 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1292 | 0.1575 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.8203 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.1269 | 0.1547 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.1269 | 0.1547 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1292 | 0.1292 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.8203 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8203 | 0.8203 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8203 | 0.8203 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.8203 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.8203 | 0.8203 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1292 | 0.1292 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.6378 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.1269 | 0.1547 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.1269 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.8203 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.092 microM | Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by microplate assay | ChEMBL. | 19879671 |
IC50 (functional) | = 25.56 microM | Antiplasmodial activity against Trypanosoma brucei rhodesiense STIB 900 by microplate assay | ChEMBL. | 19879671 |
IC50 (functional) | = 0.092 uM | Antiplasmodial activity against Plasmodium falciparum K1 infected in human blood by [3H]hypoxanthine incorporation assay | ChEMBL. | 20709557 |
IC50 (functional) | = 25.56 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 bloodstream forms after 72 hrs by serial dilution Alamar blue assay | ChEMBL. | 22136906 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 19879671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.