Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0113 | 0.099 | 0.0657 |
Echinococcus granulosus | proteasome subunit beta type 6 | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit alpha type-7, putative | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome catalytic subunit 2 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | Proteasome subunit beta type 7 precursor | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | pyruvate kinase | 0.009 | 0.0691 | 0.0404 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0833 | 1 | 1 |
Giardia lamblia | 20S proteasome alpha subunit 6 | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0833 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 3 | 0.0063 | 0.0356 | 0.0356 |
Schistosoma mansoni | proteasome subunit alpha 3 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | proteasome subunit beta type 7 | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit alpha 1 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | 20S proteasome alpha subunit 4 | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit alpha type-6, putative | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0113 | 0.099 | 0.0657 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0113 | 0.099 | 0.0657 |
Plasmodium vivax | proteasome subunit alpha type-3, putative | 0.0063 | 0.0356 | 0.0059 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0113 | 0.099 | 1 |
Plasmodium falciparum | proteasome subunit alpha type-4, putative | 0.0063 | 0.0356 | 0.0059 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0079 | 0.0561 | 0.0212 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit alpha type-4, putative | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome catalytic subunit 1 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0833 | 1 | 1 |
Toxoplasma gondii | proteasome subunit | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | proteasome subunit alpha type-3, putative | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0113 | 0.099 | 0.099 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0833 | 1 | 1 |
Echinococcus multilocularis | proteasome subunit alpha type 6 | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | 20S proteasome alpha subunit 1 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0063 | 0.0356 | 0.0059 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0113 | 0.099 | 0.0657 |
Echinococcus granulosus | proteasome prosome macropain subunit beta type | 0.0063 | 0.0356 | 0.0059 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0113 | 0.099 | 0.0657 |
Brugia malayi | proteasome subunit alpha type 1 | 0.0063 | 0.0356 | 0.0356 |
Echinococcus granulosus | proteasome subunit beta t family | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Giardia lamblia | Proteasome subunit beta type 4 precursor | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit alpha | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | proteasome subunit beta type 1 | 0.0063 | 0.0356 | 0.0356 |
Giardia lamblia | 20S proteasome alpha subunit 5 | 0.0063 | 0.0356 | 0.0059 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0833 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0113 | 0.099 | 0.0657 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0561 | 0.0212 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0113 | 0.099 | 0.0657 |
Plasmodium falciparum | ATP-dependent protease subunit ClpQ | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit alpha type-5, putative | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit alpha type, putative | 0.0063 | 0.0356 | 0.0059 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0833 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0063 | 0.0356 | 0.0356 |
Echinococcus multilocularis | Proteasome, subunit alpha beta | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | 20S proteasome alpha5 subunit | 0.0063 | 0.0356 | 0.0356 |
Plasmodium falciparum | proteasome subunit alpha type-2, putative | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | 20S proteasome alpha subunit 2 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | subfamily T1A non peptidase ue | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0063 | 0.0356 | 0.0356 |
Plasmodium vivax | proteasome subunit alpha type-2, putative | 0.0063 | 0.0356 | 0.0059 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0113 | 0.099 | 0.0657 |
Plasmodium falciparum | proteasome subunit alpha type-6, putative | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit alpha 4 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Leishmania major | pyruvate kinase | 0.0113 | 0.099 | 0.0657 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0063 | 0.0356 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 3 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | Proteasome subunit alpha beta | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | Proteasome subunit alpha type 1 | 0.0063 | 0.0356 | 0.0356 |
Giardia lamblia | Proteasome subunit beta type 9 precursor | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative | 0.0063 | 0.0356 | 0.0059 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0833 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit beta type | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | ATP-dependent protease subunit ClpQ, putative | 0.0063 | 0.0356 | 0.0059 |
Chlamydia trachomatis | pyruvate kinase | 0.0113 | 0.099 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-6, putative | 0.0063 | 0.0356 | 0.0059 |
Mycobacterium ulcerans | pyruvate kinase | 0.0113 | 0.099 | 0.0657 |
Plasmodium falciparum | proteasome subunit beta type-3, putative | 0.0063 | 0.0356 | 0.0059 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0079 | 0.0561 | 0.0212 |
Schistosoma mansoni | proteasome subunit beta 4 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0833 | 1 | 1 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0833 | 1 | 1 |
Schistosoma mansoni | proteasome subunit alpha 2 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit beta type 7 precursor, putative | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | 20S proteasome alpha subunit 7 | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | proteasome subunit alpha type 3 | 0.0063 | 0.0356 | 0.0356 |
Giardia lamblia | Pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Plasmodium vivax | proteasome subunit beta type-3, putative | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | 20S proteasome subunit alpha 6 | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit alpha1, putative | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | proteasome prosome macropain | 0.0833 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0113 | 0.099 | 1 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0063 | 0.0356 | 0.0059 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0113 | 0.099 | 0.0657 |
Plasmodium falciparum | proteasome subunit alpha type-7, putative | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0833 | 1 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0113 | 0.099 | 0.099 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0113 | 0.099 | 0.0712 |
Brugia malayi | proteasome subunit alpha type 2 | 0.0063 | 0.0356 | 0.0356 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | proteasome subunit beta type 2 | 0.0063 | 0.0356 | 0.0356 |
Schistosoma mansoni | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Echinococcus multilocularis | proteasome subunit beta type 7 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | proteasome subunit alpha type 2 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | 20S proteasome subunit alpha 6 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | proteasome prosome macropain subunit alpha | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | Proteasome subunit alpha type 7-1 | 0.0063 | 0.0356 | 0.0356 |
Mycobacterium ulcerans | proteasome PrcB | 0.0833 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-7, putative | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0833 | 1 | 1 |
Toxoplasma gondii | peptidase, T1 family protein | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0063 | 0.0356 | 0.0059 |
Plasmodium vivax | proteasome subunit beta type-4, putative | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | proteasome subunit alpha type 2 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | proteasome subunit alpha type 4 | 0.0063 | 0.0356 | 0.0356 |
Echinococcus granulosus | proteasome subunit alpha type 6 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Brugia malayi | proteasome subunit alpha type 6 | 0.0063 | 0.0356 | 0.0356 |
Giardia lamblia | 20S proteasome alpha subunit 3 | 0.0063 | 0.0356 | 0.0059 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0063 | 0.0356 | 0.0059 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0113 | 0.099 | 0.0657 |
Plasmodium falciparum | proteasome subunit beta type-4 | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | proteasome subunit alpha type-5, putative | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | 20S proteasome subunit beta 7, putative | 0.0063 | 0.0356 | 0.0059 |
Echinococcus multilocularis | proteasome subunit beta type 6 | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | subfamily T1A non peptidase ue | 0.0063 | 0.0356 | 0.0059 |
Echinococcus granulosus | Proteasome subunit alpha type 7 | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Schistosoma mansoni | proteasome subunit alpha 6 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Loa Loa (eye worm) | pyruvate kinase | 0.0113 | 0.099 | 0.0657 |
Leishmania major | pyruvate kinase | 0.0113 | 0.099 | 0.0657 |
Plasmodium vivax | pyruvate kinase, putative | 0.0113 | 0.099 | 0.0712 |
Plasmodium vivax | proteasome subunit alpha type-1, putative | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | heat shock protein hslv, putative | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome beta subunit | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | proteasome subunit alpha type-1, putative | 0.0063 | 0.0356 | 0.0059 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0063 | 0.0356 | 0.0356 |
Schistosoma mansoni | proteasome subunit alpha 7 (T01 family) | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0063 | 0.0356 | 0.0059 |
Toxoplasma gondii | proteasome subunit alpha type 1, putative | 0.0063 | 0.0356 | 0.0059 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0113 | 0.099 | 1 |
Toxoplasma gondii | proteasome subunit alpha type 5-2, putative | 0.0063 | 0.0356 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.099 | 0.0657 |
Schistosoma mansoni | pyruvate kinase | 0.0113 | 0.099 | 0.0712 |
Plasmodium falciparum | proteasome subunit beta type-7, putative | 0.0063 | 0.0356 | 0.0059 |
Plasmodium falciparum | proteasome subunit beta type-6, putative | 0.0063 | 0.0356 | 0.0059 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0833 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 3.13 ug ml-1 | In vitro antibacterial activity against Salmonella paratyphi 1015 | ChEMBL. | 3681887 |
MIC (functional) | = 12.5 ug ml-1 | In vitro antibacterial activity against Klebsiella pneumoniae PCI-602 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus FDA 209P JC-1 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Staphylococcus epidermidis IAM 1576 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Bacillus subtilis ATCC6633 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against E. coli NIHJ JC-2 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Proteus vulgaris HX-19 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa IFO 3445 | ChEMBL. | 3681887 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against E. coli NIHJ JC-2 | ChEMBL. | 3681887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.