Detailed information for compound 1082827

Basic information

Technical information
  • TDR Targets ID: 1082827
  • Name: [2-(4-bromophenyl)-2-oxoethyl]azanium chlorid e
  • MW: 250.52 | Formula: C8H9BrClNO
  • H donors: 1 H acceptors: 1 LogP: 2.19 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(=O)c1ccc(cc1)Br.Cl
  • InChi: 1S/C8H8BrNO.ClH/c9-7-3-1-6(2-4-7)8(11)5-10;/h1-4H,5,10H2;1H
  • InChiKey: ROAVTVXTYFSQEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(4-bromophenyl)-2-oxo-ethyl]ammonium chloride
  • [2-(4-bromophenyl)-2-oxoethyl]ammonium chloride
  • [2-(4-bromophenyl)-2-keto-ethyl]ammonium chloride
  • [2-(4-bromophenyl)-2-oxo-ethyl]azanium chloride
  • 5467-72-1
  • 2-Amino-1-(4-bromophenyl)ethan-1-one hydrochloride
  • 2-Amino-4'-bromoacetophenone hydrochloride
  • 4-Bromo-omega-aminoacetophenone hydrochloride
  • ACETOPHENONE, 2-AMINO-4'-BROMO-, HYDROCHLORIDE
  • EINECS 226-778-3
  • Ethanone, 2-amino-1-(4-bromophenyl)-, hydrochloride
  • NSC 25405
  • ST5408755
  • 2-amino-1-(4-bromophenyl)ethanone hydrochloride
  • 2-Amino-4′-bromoacetophenone hydrochloride
  • 415340_ALDRICH
  • SR-01000635574-1
  • ST5319465

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0047 0.0003
Schistosoma mansoni hypothetical protein 0.0011 0.0047 0.0047
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0011 0.0047 0.0003
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.2357 0.3585
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0399 0.0416
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.4276 0.4813
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0388 0.0345
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0143 0.0143
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0011 0.0047 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0945 0.0905
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Mycobacterium ulcerans hypothetical protein 0.0038 0.0658 0.2144
Leishmania major NADH dehydrogenase, putative 0.0011 0.0047 0.0016
Brugia malayi hypothetical protein 0.0017 0.0189 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0945 0.0905
Entamoeba histolytica deoxycytidyl transferase, putative 0.0122 0.2553 0.2853
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0945 0.0945
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.003 0.0476 0.0491
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0041 0.0718 0.0767
Mycobacterium tuberculosis Possible toxin MazF1 0.0138 0.2894 0.4419
Echinococcus multilocularis GPCR, family 2 0.0016 0.017 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Echinococcus granulosus cpg binding protein 0.0064 0.1244 0.1205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0122 0.2553 0.2853
Loa Loa (eye worm) hypothetical protein 0.0022 0.0306 0.0298
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.2357 0.2323
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0718 0.0778
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0402 0.8837 1
Echinococcus multilocularis cpg binding protein 0.0064 0.1244 0.1205
Trichomonas vaginalis CAMK family protein kinase 0.0199 0.4276 0.4813
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.2692 0.2692
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0226 0.0207
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0047 0.0003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0298 0.649 1
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0011 0.0047 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.2357 0.2639
Plasmodium vivax thioredoxin reductase, putative 0.0117 0.2441 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.2357 1
Mycobacterium tuberculosis Toxin MazF3 0.0138 0.2894 0.4419
Loa Loa (eye worm) hypothetical protein 0.0167 0.3546 0.3983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0229 0.0223
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0538 0.0573
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0494 0.1915
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0047 0.0047
Trichomonas vaginalis helicase, putative 0.0014 0.0113 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0494 0.0512
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0113 0.0078
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.017
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0454 0.0411
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0011 0.0047 0.0003
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.2357 0.2639
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0041 0.0718 0.1042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.023 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0399 0.0416
Echinococcus granulosus glutamate synthase 0.0011 0.0047 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.2553 0.3889
Entamoeba histolytica thioredoxin reductase, putative 0.0011 0.0047 0.0003
Trypanosoma brucei DNA damage repair protein, putative 0.0038 0.0658 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0658 0.0709
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0011 0.0047 0.0059
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0143 0.0099
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0047 0.0016
Giardia lamblia DINP protein human, muc B family 0.0122 0.2553 0.285
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0658 0.0709
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0653 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0072 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Mycobacterium tuberculosis Possible toxin MazF5 0.0138 0.2894 0.4419
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0718 0.0778
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0538 0.0561
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.2357 0.2323
Plasmodium falciparum thioredoxin reductase 0.0117 0.2441 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0229 0.0223
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0226 0.0183
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0011 0.0047 0.0003
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0011 0.0047 0.0003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0117 0.2441 0.3716
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.2357 0.263
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.17 0.1893
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0229 0.0223
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0494 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0945 0.0945
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0143 0.0099
Trichomonas vaginalis mercuric reductase, putative 0.0041 0.0718 0.0767
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.2357 0.263
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0047 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0122 0.2553 0.2862
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0011 0.0047 0.0208
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0047 0.0016
Giardia lamblia Kinase, PLK 0.0402 0.8837 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0119 0.2476 0.2443
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0011 0.0047 0.0003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0538 0.0573
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0268 0.5819 0.8958
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0538 0.0573
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0011 0.0047 0.0208
Onchocerca volvulus 0.0167 0.3546 0.398
Loa Loa (eye worm) phosphofructokinase 0.0114 0.2357 0.263
Mycobacterium tuberculosis Toxin MazF9 0.0138 0.2894 0.4419
Mycobacterium tuberculosis Probable dehydrogenase 0.0268 0.5819 0.8958
Toxoplasma gondii NADPH-glutathione reductase 0.0041 0.0718 0.2846
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Brugia malayi 6-phosphofructokinase 0.0114 0.2357 0.263
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0229 0.0815
Brugia malayi glutamate synthase 0.0011 0.0047 0.0003
Leishmania major trypanothione reductase 0.0117 0.2441 0.2735
Trypanosoma cruzi NADH dehydrogenase, putative 0.0011 0.0047 0.0016
Plasmodium vivax glutathione reductase, putative 0.0117 0.2441 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.017 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.017 0.0126
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0143 0.0099
Leishmania major DNA damage repair protein, putative 0.0038 0.0658 0.0709
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0945 0.0905
Brugia malayi ImpB/MucB/SamB family protein 0.0122 0.2553 0.2853
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0454 0.0463
Onchocerca volvulus 0.0061 0.1166 0.1273
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0388 0.0345
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0143 0.0099
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0041 0.0718 0.2357
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0122 0.2553 0.252
Trypanosoma brucei DNA damage repair protein, putative 0.0038 0.0658 0.0709
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0229 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0402 0.8837 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0047 0.0003
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0072 0.016
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0658 0.0709
Entamoeba histolytica hypothetical protein 0.0038 0.0653 0.0693
Trichomonas vaginalis rotamase, putative 0.0033 0.0556 0.0582
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0959 0.1041
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.2357 0.263
Plasmodium falciparum thioredoxin reductase 0.0041 0.0718 0.2803
Schistosoma mansoni glutamate synthase 0.0011 0.0047 0.0047
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0047 0.0016
Trypanosoma brucei trypanothione reductase 0.0117 0.2441 0.2735
Mycobacterium tuberculosis Conserved protein 0.0138 0.2894 0.4419
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0047 0.0003
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0494 0.1915
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0011 0.0047 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0038 0.0658 0.2594
Trypanosoma brucei DNA polymerase IV, putative 0.0122 0.2553 0.2862
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0388 0.0391
Trypanosoma cruzi DNA damage repair protein, putative 0.0038 0.0658 0.0709
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0041 0.0718 0.2803
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0047 0.0059
Plasmodium falciparum glutathione reductase 0.0117 0.2441 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0653 0.0653
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0011 0.0047 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0041 0.0718 0.0778
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0454 0.0478
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.017 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0047 0.0016
Trichomonas vaginalis rotamase, putative 0.0033 0.0538 0.0561
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0945 0.1024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0113 0.0078
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0122 0.2553 0.2862
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0268 0.5819 0.8958
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0011 0.0047 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.017 0.0143
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0221 0.0201
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0594 0.0625
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0306 0.031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0959 0.1041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0113 0.0078
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0494 0.0508
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0041 0.0718 0.0778
Leishmania major DNA polymerase eta, putative 0.0122 0.2553 0.2862
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.2357 0.263
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0402 0.8837 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.017 0.0143
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.2357 0.263
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0041 0.0718 0.0778
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0229 0.0223
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0047 0.0047
Trypanosoma brucei unspecified product 0.0122 0.2553 0.2862
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0229 0.0186
Brugia malayi glutathione reductase 0.0117 0.2441 0.2726
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0122 0.2553 0.2853
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0072 0.0044
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0399 0.1471
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.2357 0.2639
Echinococcus multilocularis glutamate synthase 0.0011 0.0047 0.0003
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0494 0.0512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0113 0.0078
Entamoeba histolytica serine/threonine protein kinase, putative 0.0402 0.8837 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0402 0.8837 0.8832
Leishmania major hypothetical protein, conserved 0.0011 0.0047 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Mycobacterium tuberculosis Probable oxidoreductase 0.0298 0.649 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0011 0.0047 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma cruzi polo-like protein kinase, putative 0.0402 0.8837 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0038 0.0658 0.255
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0041 0.0718 0.0778
Trypanosoma brucei chrX additional, unordered contigs 0.0038 0.0658 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Schistosoma mansoni cpg binding protein 0.0064 0.1244 0.1244
Loa Loa (eye worm) programmed cell death 8 0.0011 0.0047 0.0003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0122 0.2553 0.2553
Entamoeba histolytica hypothetical protein 0.0038 0.0653 0.0693
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0658 0.0709
Trypanosoma brucei unspecified product 0.0084 0.17 0.1893
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.2357 0.8112
Schistosoma mansoni DNA polymerase IV / kappa 0.0038 0.0658 0.0658
Entamoeba histolytica disulphide oxidoreductase, putative 0.0011 0.0047 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0041 0.0718 0.0778
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0494 0.1867
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0298 0.649 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0011 0.0047 0.0003
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0011 0.0047 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0047 0.0016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0229 0.0229
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0011 0.0047 0.0059
Toxoplasma gondii thioredoxin reductase 0.0117 0.2441 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0047 0.0016
Schistosoma mansoni hypothetical protein 0.0454 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0041 0.0718 0.2803
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0268 0.5819 0.8958
Echinococcus multilocularis dna polymerase kappa 0.0122 0.2553 0.252
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0071 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0298 0.649 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0011 0.0047 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Trypanosoma cruzi DNA polymerase eta, putative 0.0122 0.2553 0.2862
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0226 0.0183
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0229 0.0223
Brugia malayi serine/threonine-protein kinase plk-2 0.0402 0.8837 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Plasmodium falciparum glutathione reductase 0.0041 0.0718 0.2803
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0011 0.0047 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.1166 0.1276
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0047 0.0003
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0011 0.0047 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0388 0.0403
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0229 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0594 0.0625
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0454 0.1748
Mycobacterium tuberculosis Toxin MazF6 0.0138 0.2894 0.4419
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Loa Loa (eye worm) hypothetical protein 0.0011 0.0047 0.0003
Leishmania major DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Loa Loa (eye worm) hypothetical protein 0.0038 0.0658 0.0698
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0113 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0041 0.0718 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0454 0.0466
Trypanosoma brucei DNA polymerase IV, putative 0.0122 0.2553 0.2862
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0047 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0041 0.0718 0.2357
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.0122 0.2553 0.88
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0494 0.1867
Echinococcus multilocularis thioredoxin glutathione reductase 0.0119 0.2476 0.2443
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.003 0.0476 0.0491
Giardia lamblia NADH oxidase lateral transfer candidate 0.0041 0.0718 0.0763
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0047 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0122 0.2553 0.3889
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0454 0.0466
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0494 0.0512
Brugia malayi CXXC zinc finger family protein 0.0061 0.1166 0.1276
Loa Loa (eye worm) hypothetical protein 0.0122 0.2553 0.2853
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0268 0.5819 0.8958
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0229 0.0223
Leishmania major DNA polymerase kappa, putative 0.0038 0.0658 0.0709
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0229 0.0223
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.2357 0.2357
Schistosoma mansoni disulfide oxidoreductase 0.0011 0.0047 0.0047
Onchocerca volvulus Serine\/threonine kinase homolog 0.0402 0.8837 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0047 0.0016
Entamoeba histolytica hypothetical protein 0.0026 0.0388 0.0391
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0494 0.1935
Schistosoma mansoni hypothetical protein 0.0038 0.0653 0.0653
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0011 0.0047 0.0003
Mycobacterium tuberculosis Possible toxin MazF7 0.0138 0.2894 0.4419
Trypanosoma cruzi trypanothione reductase, putative 0.0117 0.2441 0.2735
Echinococcus granulosus GPCR family 2 0.0016 0.017 0.0126
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0494 0.0512
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0047 0.0016
Schistosoma mansoni cpg binding protein 0.0064 0.1244 0.1244
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0229 0.0211
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0945 0.0905
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0494 0.0512
Plasmodium falciparum flap endonuclease 1 0.0029 0.0454 0.1699
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0556 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0072 0.0031
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0538 0.0573
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0494 0.1867
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.17 0.1893
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0229 0.0223
Schistosoma mansoni rotamase 0.0033 0.0556 0.0556
Giardia lamblia DNA damage repair protein 0.0038 0.0658 0.0694
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0047 0.0003
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0402 0.8837 0.8832
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0658 0.0709
Brugia malayi phosphofructokinase 0.0114 0.2357 0.263
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0388 0.1474
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0175 0.3721 0.3694
Schistosoma mansoni terminal deoxycytidyl transferase 0.0122 0.2553 0.2553
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.2357 0.263
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0113 0.0078
Mycobacterium ulcerans hypothetical protein 0.0138 0.2894 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0454 0.0466
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0047 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.4511 0.508
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0041 0.0718 0.2803
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0229 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0454 0.0478
Leishmania major hypothetical protein, conserved 0.0026 0.0399 0.0416
Echinococcus granulosus expressed protein 0.0033 0.0556 0.0514
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0229 0.0186
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0494 0.1867
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0041 0.0718 0.2846
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.2608 0.2915
Trypanosoma cruzi DNA damage repair protein, putative 0.0038 0.0658 0.0709
Loa Loa (eye worm) thioredoxin reductase 0.0117 0.2441 0.2726
Echinococcus multilocularis dna polymerase eta 0.0122 0.2553 0.252
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0047 0.0003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0122 0.2553 0.252
Trypanosoma brucei polo-like protein kinase 0.0402 0.8837 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0044 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0658 0.0709
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0229 0.0211
Mycobacterium tuberculosis Probable reductase 0.0268 0.5819 0.8958
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.017
Entamoeba histolytica hypothetical protein 0.0038 0.0653 0.0693
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0113 0.0078
Leishmania major hypothetical protein, conserved 0.0011 0.0047 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Echinococcus granulosus dna polymerase kappa 0.0122 0.2553 0.252
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0494 0.6659
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0229 0.0229
Brugia malayi Flap endonuclease-1 0.0029 0.0454 0.0466
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0041 0.0718 0.0677
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0041 0.0718 0.0677
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.2357 0.2357
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0047 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.017
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0229 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0388 0.0391
Schistosoma mansoni glutamate synthase 0.0011 0.0047 0.0047
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0494 0.6659
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0229 0.0211
Echinococcus multilocularis expressed protein 0.0033 0.0556 0.0514
Trichomonas vaginalis apoptosis inducing factor, putative 0.0011 0.0047 0.0003
Mycobacterium tuberculosis Possible toxin MazF4 0.0138 0.2894 0.4419
Mycobacterium ulcerans DNA polymerase IV 0.0122 0.2553 0.88
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Loa Loa (eye worm) hypothetical protein 0.021 0.4511 0.508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.2553 0.2862
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0229 0.0211
Schistosoma mansoni DNA polymerase eta 0.0122 0.2553 0.2553
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.2384 0.9762
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0229 0.0223
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.2357 0.263
Plasmodium vivax DNA repair protein REV1, putative 0.0038 0.0658 0.255
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0229 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Mycobacterium tuberculosis Toxin MazF2 0.0138 0.2894 0.4419
Trypanosoma cruzi polo-like protein kinase, putative 0.0402 0.8837 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0047 0.0059
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0658 0.2594
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0538 0.2096
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.023 0.0224
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0229 0.0223
Schistosoma mansoni hypothetical protein 0.0035 0.0594 0.0594
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0388 0.0388
Trypanosoma brucei NADH dehydrogenase 0.0011 0.0047 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Schistosoma mansoni hypothetical protein 0.0016 0.017 0.017
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0658 0.0709
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0047 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0399 0.0416
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0718 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0113 0.0078
Brugia malayi ImpB/MucB/SamB family protein 0.0122 0.2553 0.2853
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0399 0.1471
Schistosoma mansoni kinase 0.0205 0.4395 0.4395
Echinococcus granulosus dna polymerase eta 0.0122 0.2553 0.252
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0041 0.0718 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.2357 0.3585
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0388 0.0403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0399 0.0404
Giardia lamblia GTOR 0.0019 0.0229 0.0207
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0011 0.0047 0.0003
Brugia malayi MH2 domain containing protein 0.0125 0.2608 0.2915
Schistosoma mansoni flap endonuclease-1 0.0026 0.0392 0.0392
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.2357 0.263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Brugia malayi polk-prov protein 0.0038 0.0658 0.0698
Leishmania major hypothetical protein, conserved 0.0011 0.0047 0.0016
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0044 0.0044
Echinococcus multilocularis dnaJ subfamily B 0.0454 1 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0494 0.1915
Leishmania major DNA polymerase eta, putative 0.0038 0.0658 0.0709
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0011 0.0047 0.0016
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.2357 0.263
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0494 0.0512
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0011 0.0047 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0399 0.1521
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0229 0.0223
Schistosoma mansoni hypothetical protein 0.0012 0.0071 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Trichomonas vaginalis glutamate synthase, putative 0.0011 0.0047 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Schistosoma mansoni glutamate synthase 0.0011 0.0047 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0399 0.1471
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.17 0.1893
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0556 0.0582
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0011 0.0047 0.0016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0041 0.0718 0.0778
Brugia malayi 6-phosphofructokinase 0.0114 0.2357 0.263
Treponema pallidum NADH oxidase 0.0041 0.0718 0.2906
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0229 0.0186
Trichomonas vaginalis DNA polymerase eta, putative 0.0122 0.2553 0.2853
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0945 0.1024
Brugia malayi hypothetical protein 0.0038 0.0653 0.0693
Trichomonas vaginalis glutathione reductase, putative 0.0041 0.0718 0.0767
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0229 0.0223
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0454 0.0478
Echinococcus granulosus flap endonuclease 1 0.0029 0.0454 0.0411
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0011 0.0047 0.0003
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0011 0.0047 0.0059
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0175 0.3721 0.3694
Brugia malayi Latrophilin receptor protein 2 0.0016 0.017 0.0143
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0454 0.1699
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0268 0.5819 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Brugia malayi Thioredoxin reductase 0.0117 0.2441 0.2726
Brugia malayi hypothetical protein 0.0026 0.0399 0.0404
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0041 0.0718 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0011 0.0047 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0718 0.0778
Schistosoma mansoni cpg binding protein 0.0061 0.1166 0.1166
Brugia malayi hypothetical protein 0.0167 0.3546 0.3983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0071 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.2608 0.2915
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0041 0.0718 1
Entamoeba histolytica hypothetical protein 0.0038 0.0653 0.0693
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0229 0.0211
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0658 0.2594
Toxoplasma gondii selenide, water dikinase 0.0011 0.0047 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0945 0.0945
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0653 0.0612
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0011 0.0047 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0041 0.0718 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0047 0.0003
Loa Loa (eye worm) glutathione reductase 0.0117 0.2441 0.2726
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0011 0.0047 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0229 0.0211
Trichomonas vaginalis CAMK family protein kinase 0.0402 0.8837 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0494 0.0512
Trypanosoma brucei DNA polymerase IV, putative 0.0122 0.2553 0.2862
Trypanosoma brucei unspecified product 0.0084 0.17 0.1893
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0011 0.0047 0.0003
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0556 0.0582
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0041 0.0718 0.2357
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0113 0.0078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0072 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0122 0.2553 0.2862

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 100 uM Inhibition of GSK3-beta using GS1 as substrate and [gamma-32P]ATP after 20 mins by radiometric assay ChEMBL. 21500862

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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