Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.4109 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.4109 | 0.5 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.4109 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.4109 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.4109 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.4109 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.4109 | 0.4109 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.4109 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.4109 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.4109 | 0.3435 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.4109 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.4109 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.4109 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.4109 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.4109 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.4109 | 0.4109 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1026 | 0.1026 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.4109 | 0.4109 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9646 | 0.9646 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.4109 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.4109 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.