Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | smad | 0.0009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0204 | 0.024 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3557 | 0.3557 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0324 | 0.0324 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0324 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0153 | 0.8512 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0153 | 0.8512 | 0.8512 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0153 | 0.8512 | 0.8512 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.696 | 0.8177 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0324 | 0.0324 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.696 | 0.8177 |
Onchocerca volvulus | 0.0011 | 0.0324 | 1 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0035 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0324 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3557 | 0.4179 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0204 | 0.024 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0204 | 0.0204 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.2083 | 0.5 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3557 | 0.4179 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.3398 | 0.5 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3557 | 0.3557 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0324 | 0.0324 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.2083 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0153 | 0.8512 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.2299 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3557 | 0.3557 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3557 | 0.4179 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0204 | 0.0204 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | smad | 0.0009 | 0.0204 | 0.0204 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3557 | 0.3557 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0035 | 0.0035 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.3398 | 0.3398 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.696 | 0.8177 |
Echinococcus multilocularis | geminin | 0.0179 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.3398 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0324 | 0.0381 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0324 | 0.0381 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.3398 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0204 | 0.024 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3557 | 0.4179 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0324 | 0.0324 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.3398 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.2083 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3557 | 0.3557 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0204 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0324 | 0.0324 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0324 | 0.0324 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.2299 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0204 | 0.0204 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.8265 | 0.8265 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0204 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0324 | 0.0381 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.3398 | 0.3398 |
Echinococcus multilocularis | smad | 0.0009 | 0.0204 | 0.0204 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.0035 | 0.0035 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0324 | 0.0381 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0324 | 0.0324 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0324 | 0.0324 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0035 | 0.0041 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3557 | 0.4179 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3557 | 0.3557 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0204 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.2299 | 0.2299 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.0035 | 0.0041 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0204 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0035 | 0.0041 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0204 | 0.0204 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0324 | 0.0324 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0324 | 0.0381 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0324 | 0.0381 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0324 | 0.0324 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0324 | 0.0381 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0324 | 0.0324 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0204 | 0.0204 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.3398 | 0.3398 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0204 | 0.0204 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0324 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0324 | 0.0381 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0324 | 0.0324 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0324 | 0.0324 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.3398 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0204 | 0.024 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0324 | 0.0381 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.2299 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.0035 | 0.0035 |
Brugia malayi | Smad1 | 0.0009 | 0.0204 | 0.024 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0324 | 0.0381 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0204 | 0.0204 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.0035 | 0.0035 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3557 | 0.4179 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.3398 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.3398 | 0.3398 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0324 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0035 | 0.0041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3557 | 0.3557 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0204 | 0.0204 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 29 % | Stability of the compound in 80% human blood serum assessed as hydrolysis to 2-bromo-6-(1H-imidazol-1-yl)-7H-indeno[2,1-c]quinolin-7-one oxime at 1 mg after 24 hrs at 37 degC by LC-MS analysis | ChEMBL. | 21334792 |
Activity (ADMET) | = 68 % | Cytotoxicity against human U937 cells assessed as cell viability at 1.25 ug/ml after 72 hrs by MTT assay | ChEMBL. | 21334792 |
Activity (ADMET) | = 73 % | Cytotoxicity against human U937 cells assessed as cell viability at 10 ug/ml after 72 hrs by MTT assay | ChEMBL. | 21334792 |
MIC (functional) | = 6 ug ml-1 | Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 16 to 24 hrs by microplate alamar blue assay | ChEMBL. | 21334792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.