TDR Targets

Basic information

Technical information

TDR Targets ID: 1083836
Name: 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6- methyl-2-oxopyridin-1-yl]-4-(hydroxymethyl)-N -methylbenzamide
MW: 493.298 | Formula: C22H19BrF2N2O4
H donors: 2 H acceptors: 3 LogP: 3 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCc1ccc(cc1n1c(C)cc(c(c1=O)Br)OCc1ccc(cc1F)F)C(=O)NC
InChi: 1S/C22H19BrF2N2O4/c1-12-7-19(31-11-15-5-6-16(24)9-17(15)25)20(23)22(30)27(12)18-8-13(21(29)26-2)3-4-14(18)10-28/h3-9,28H,10-11H2,1-2H3,(H,26,29)
InChiKey: WGROYRNAUJEBMH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1-pyridyl]-4-(hydroxymethyl)-N-methyl-benzamide
3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1-pyridyl]-4-(hydroxymethyl)-N-methylbenzamide
3-[3-bromo-4-(2,4-difluorobenzyl)oxy-2-keto-6-methyl-1-pyridyl]-N-methyl-4-methylol-benzamide
3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-pyridin-1-yl]-4-(hydroxymethyl)-N-methyl-benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0062	0.0062
Loa Loa (eye worm)	PHD-finger family protein	0.0043	0.1052	0.1052
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.2667	0.2667
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1818	0.1818
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0721	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0042	0.1004	0.0948
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0236	0.0287
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0062	0.0062
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0068	0.1818	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0687	0.0687
Echinococcus multilocularis	zinc finger protein	0.0041	0.0984	0.0928
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0687	0.0629
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0104	0.2927	1
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.4408	0.4373
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0687	0.6362
Leishmania major	trypanothione reductase	0.0041	0.0988	0.1944
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0204	0.5999	0.5974
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Leishmania major	GTP-binding protein, putative	0.0023	0.0433	0.0638
Onchocerca volvulus		0.0032	0.0721	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0505	0.0459
Treponema pallidum	NADH oxidase	0.0014	0.0162	0.5
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0505	0.0808
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0052	0.1317	0.1263
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0094	0.2605	0.8837
Trypanosoma brucei	ISWI complex protein	0.0032	0.0709	0.1287
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0433	0.0638
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0062	0.0024
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0036	0.0822	0.0764
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.2667	0.2667
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0062	0.0024
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0236	0.0175
Schistosoma mansoni	bromodomain containing protein	0.0132	0.3795	0.3795
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.2667	0.2621
Schistosoma mansoni	hypothetical protein	0.0032	0.0709	0.0709
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0062	0.0062
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0433	0.3282
Echinococcus multilocularis	polycomb protein SCMH1	0.0052	0.1317	0.1263
Echinococcus granulosus	geminin	0.017	0.4968	0.4936
Loa Loa (eye worm)	MBCTL1	0.0059	0.1537	0.1537
Brugia malayi	steroid hormone receptor	0.0011	0.0062	0.0024
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0062	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1317	0.1317
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0988	0.0988
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0075	0.2036	0.1986
Loa Loa (eye worm)	bromodomain containing protein	0.0037	0.0861	0.0861
Echinococcus granulosus	SAM and MBT domain containing protein	0.0052	0.1317	0.1263
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0062	0.0062
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0721	0.0721
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0721	0.0721
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0068	0.1818	0.1767
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0062	0.0062
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.1317	0.1317
Brugia malayi	Thioredoxin reductase	0.0041	0.0988	0.1421
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.1317	0.1317
Loa Loa (eye worm)	hypothetical protein	0.008	0.2193	0.2193
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0433	0.0638
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0236	0.0236
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0062	0.0024
Schistosoma mansoni	hypothetical protein	0.0036	0.083	0.083
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0988	1
Leishmania major	hypothetical protein, conserved	0.0032	0.0709	0.1287
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0162	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0062	0.0062
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0094	0.2605	0.8837
Brugia malayi	mbt repeat family protein	0.0052	0.1317	0.1918
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0062	0.0024
Mycobacterium tuberculosis	Probable oxidoreductase	0.0104	0.2927	1
Brugia malayi	Importin beta-1 subunit	0.0031	0.0687	0.0968
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0433	0.0433
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0988	1
Brugia malayi	PHD-finger family protein	0.0052	0.1327	0.1933
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0036	0.0822	0.0822
Echinococcus granulosus	thioredoxin glutathione reductase	0.0042	0.1004	0.0948
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0988	1
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0062	0.0062
Echinococcus multilocularis	geminin	0.017	0.4968	0.4936
Schistosoma mansoni	hypothetical protein	0.0334	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.4274	0.4274
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0052	0.1317	0.1317
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.2667	0.2621
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0062	0.0024
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0062	0.0062
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0014	0.0162	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0062	0.0062
Loa Loa (eye worm)	mbt repeat family protein	0.0052	0.1317	0.1317
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0062	0.0024
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.6672	0.6672
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.4408	0.4373
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0047	0.1175	0.1175
Schistosoma mansoni	importin beta-1	0.0031	0.0687	0.0687
Echinococcus granulosus	polycomb protein SCMH1	0.0052	0.1317	0.1263
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0721	0.6773
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0505	0.0459
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0125	0.3565	0.3525
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1341	0.1955
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0062	0.0024
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0014	0.0162	0.5
Brugia malayi	ecdysteroid receptor	0.0011	0.0062	0.0024
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0162	0.5
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0433	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.0236
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.1537	0.1537
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0052	0.1317	0.1658
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0433	0.0638
Brugia malayi	Pre-SET motif family protein	0.0226	0.6672	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0062	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0062	0.0062
Brugia malayi	Bromodomain containing protein	0.0157	0.4549	0.6796
Schistosoma mansoni	ran	0.0023	0.0433	0.0433
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0062	0.0024
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0433	0.0373
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0062	0.0062
Brugia malayi	mbt repeat family protein	0.0052	0.1317	0.1918
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.4408	1
Plasmodium falciparum	importin beta, putative	0.0031	0.0687	0.6362
Schistosoma mansoni	hypothetical protein	0.0043	0.1052	0.1052
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0685	0.0626
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.4408	0.4373
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1341	0.1955
Onchocerca volvulus		0.0052	0.1317	0.1658
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0988	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Echinococcus granulosus	fetal alzheimer antigen falz	0.0047	0.1175	0.112
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.2667	0.2667
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0094	0.2605	0.8837
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.4408	0.4373
Mycobacterium tuberculosis	Probable dehydrogenase	0.0094	0.2605	0.8837
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.083	0.1183
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0236	0.0175
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0036	0.0822	0.0764
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0988	0.1944
Trypanosoma cruzi	ISWI complex protein	0.0032	0.0709	0.1287
Schistosoma mansoni	hypothetical protein	0.017	0.4968	0.4968
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.4408	0.4373
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.4408	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0433	0.3282
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0062	0.0024
Brugia malayi	P38 map kinase family protein 2	0.0152	0.4408	0.6583
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0334	1	1
Trypanosoma cruzi	ISWI complex protein	0.0032	0.0709	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0062	0.0062
Plasmodium vivax	SET domain protein, putative	0.0032	0.0721	0.6773
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.1537	0.2251
Mycobacterium tuberculosis	Probable reductase	0.0094	0.2605	0.8837
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0062	0.0062
Brugia malayi	RNA, U transporter 1	0.0089	0.2462	0.3646
Plasmodium falciparum	glutathione reductase	0.0041	0.0988	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.1537	0.1484
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0062	0.0024
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0687	0.1237
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0104	0.2927	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0062	0.0024
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0236	0.0287
Schistosoma mansoni	zinc finger protein	0.0041	0.0984	0.0984
Schistosoma mansoni	hypothetical protein	0.017	0.4968	0.4968
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.0236
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0062	0.0062
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0062	0.0024
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0505	0.0808
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0014	0.0162	0.5
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0687	0.6362
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2468	0.2468
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.0236
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1341	0.1341
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1537	0.1537
Brugia malayi	Bromodomain containing protein	0.008	0.2188	0.3233
Onchocerca volvulus		0.0257	0.7632	1
Brugia malayi	glutathione reductase	0.0041	0.0988	0.1421
Echinococcus multilocularis	snurportin 1	0.0334	1	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0062	0.0062
Echinococcus granulosus	GPCR family 2	0.0017	0.0236	0.0175
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0162	0.5
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0505	0.0459
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0036	0.0822	0.0822
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0687	0.1237
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.4408	0.4373
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.2667	0.3955
Schistosoma mansoni	ran	0.0023	0.0433	0.0433
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0062	0.0062
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0236	0.0175
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.4408	0.4408
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.1537	0.1484
Schistosoma mansoni	hypothetical protein	0.0314	0.9404	0.9404
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.2667	0.2621
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.4408	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.2667	0.2667
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0236	0.0175
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0162	0.0101
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0988	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0085	0.2345	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0036	0.083	0.083
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0047	0.1175	0.112
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0062	0.0062
Schistosoma mansoni	zinc finger protein	0.0032	0.0709	0.0709
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0094	0.2605	0.8837
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0062	0.0062
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0433	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0062	0.0062
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0433	0.0584
Entamoeba histolytica	hypothetical protein	0.0025	0.0505	1
Brugia malayi	nuclear hormone receptor	0.0011	0.0062	0.0024
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0104	0.2927	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0068	0.1818	0.1767
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.7632	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0062	0.0024
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0433	0.0373
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0687	0.0629
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0062	0.0062
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.1537	0.1484
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0062	0.0062
Echinococcus granulosus	zinc finger protein	0.0041	0.0984	0.0928
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0062	0.0024
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.1537	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1818	0.1818
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.2667	0.2621
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0162	0.0175
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0162	0.0101
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0162	0.0162
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.4408	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0236	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0236	0.0236
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0204	0.5999	0.5974
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0075	0.2036	0.1986
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0988	0.2985
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0062	0.0062
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0062	0.0024
Trypanosoma brucei	trypanothione reductase	0.0041	0.0988	0.1944
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1341	0.1341
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0236	0.0175
Brugia malayi	Pre-SET motif family protein	0.0032	0.0721	0.1019
Trichomonas vaginalis	ran, putative	0.0023	0.0433	0.0363
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0125	0.3565	0.3525

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 325 nM	Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay	ChEMBL.	21641211

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1802640

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1083836