Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1351 | 0.1469 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.0073 | 0.358 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1028 | 0.0911 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1187 | 0.101 |
Onchocerca volvulus | Dual oxidase homolog | 0.0156 | 0.9196 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.1155 | 0.0974 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0128 | 0.0128 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.1189 | 0.1075 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0156 | 0.9196 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0156 | 0.9196 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.5059 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.5059 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.5059 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0021 | 0.0032 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.4412 | 0.8342 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2625 | 0.2529 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.4412 | 0.8342 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1687 | 0.1571 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.4412 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.1155 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.1155 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.4412 | 0.8342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1687 | 0.1687 |
Treponema pallidum | hypothetical protein | 0.0021 | 0.0032 | 0.5 |
Brugia malayi | glutathione reductase | 0.0037 | 0.1155 | 0.0974 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.5059 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1687 | 0.1835 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.1155 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.423 | 0.4599 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2625 | 0.2529 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1687 | 0.1579 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0073 | 0.358 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1028 | 0.0911 |
Leishmania major | ferric reductase, putative | 0.0073 | 0.358 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1687 | 0.1687 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.3653 | 0.3778 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1192 | 0.1296 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.1155 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.0073 | 0.358 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.1189 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1479 | 0.1609 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1687 | 0.1579 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.4412 | 0.8342 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1687 | 0.1579 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1687 | 0.1579 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1687 | 0.1687 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.2866 | 0.2866 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.4412 | 0.8342 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.1155 | 0.1256 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.1155 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3366 | 0.366 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.1155 | 0.1256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.