Detailed information for compound 1084382

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.256 | Formula: C18H19Cl2NO
  • H donors: 1 H acceptors: 1 LogP: 5.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1N(CCc2ccc(c(c2)Cl)Cl)CCc2c1cccc2O
  • InChi: 1S/C18H19Cl2NO/c1-12-14-3-2-4-18(22)15(14)8-10-21(12)9-7-13-5-6-16(19)17(20)11-13/h2-6,11-12,22H,7-10H2,1H3
  • InChiKey: CUTCUHNFFDPVPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1015 0.3368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0399 0.1323
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0365 0.3743
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0139 0.0139
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.078 0.2586
Loa Loa (eye worm) hypothetical protein 0.001 0.0167 0.0554
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0139 0.0462
Schistosoma mansoni cpg binding protein 0.003 0.0657 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0399 0.1323
Trichomonas vaginalis ferritin, putative 0.0008 0.0117 0.1499
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0399 0.0399
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.078 0.078
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0167 0.0167
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0399 0.1323
Entamoeba histolytica hypothetical protein 0.0036 0.0795 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Brugia malayi tailless protein 0.0009 0.0139 0.0462
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.078 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0167 0.0554
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0399 0.5115
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0139 0.0462
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0399 0.1323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0068 0.0875
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0139 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1015 0.1015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.078 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0084 0.0084
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0139 0.0462
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0167 0.0554
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0399 0.0399
Schistosoma mansoni cpg binding protein 0.003 0.0657 0.0657
Brugia malayi hypothetical protein 0.0009 0.0139 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0399 0.1323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0068 0.0875
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.078 0.1423
Brugia malayi conserved hypotetical protein 0.0009 0.0139 0.0462
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0399 0.0399
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0139 0.0139
Echinococcus multilocularis ferritin 0.0008 0.0117 0.0117
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0365 0.1211
Trichomonas vaginalis helicase, putative 0.0006 0.0068 0.0875
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0139 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0399 0.1323
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.078 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0365 1
Schistosoma mansoni hypothetical protein 0.0036 0.0795 0.0795
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.078 1
Echinococcus multilocularis tar DNA binding protein 0.0125 0.3015 0.3015
Mycobacterium leprae conserved hypothetical protein 0.0035 0.078 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0399 0.0399
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0399 0.1323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0068 0.0875
Schistosoma mansoni nuclear receptor 0.0009 0.0139 0.0139
Brugia malayi nuclear receptor RXR 0.0009 0.0139 0.0462
Schistosoma mansoni zinc finger protein 0.0009 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Schistosoma mansoni apoferritin-2 0.0008 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.078 0.2586
Brugia malayi hypothetical protein 0.0036 0.0795 0.2638
Leishmania major hypothetical protein, conserved 0.0035 0.078 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.078 1
Schistosoma mansoni ferritin 0.0008 0.0117 0.0117
Onchocerca volvulus 0.0035 0.078 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.078 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0399 0.1323
Onchocerca volvulus 0.0035 0.078 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.125 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0365 0.2919
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0167 0.0167
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0068 0.0875
Loa Loa (eye worm) hypothetical protein 0.0035 0.078 0.2586
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Onchocerca volvulus 0.0009 0.0139 0.1787
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0795 0.0795
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0139 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3015 0.3015
Onchocerca volvulus 0.0029 0.0616 0.7905
Entamoeba histolytica hypothetical protein 0.0036 0.0795 1
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.3015 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0139 0.0139
Schistosoma mansoni ferritin 0.0008 0.0117 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0365 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.078 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0084 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.078 0.1423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0365 0.4681
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Trichomonas vaginalis esterase, putative 0.0035 0.078 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.078 0.2586
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Schistosoma mansoni cpg binding protein 0.0029 0.0616 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0399 0.1323
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0127 0.0421
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0068 0.0875
Schistosoma mansoni apoferritin-2 0.0008 0.0117 0.0117
Schistosoma mansoni thyroid hormone receptor 0.002 0.0399 0.0399
Brugia malayi RNA binding protein 0.0125 0.3015 1
Loa Loa (eye worm) DR-78 0.0009 0.0139 0.0462
Brugia malayi nuclear hormone receptor 0.0009 0.0139 0.0462
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0399 0.5115
Brugia malayi nuclear receptor NHR-67 0.0009 0.0139 0.0462
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3015 0.3015
Brugia malayi nuclear hormone receptor 0.002 0.0399 0.1323
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0399 0.0399
Schistosoma mansoni ferritin 0.0008 0.0117 0.0117
Mycobacterium ulcerans beta-lactamase 0.0035 0.078 1
Schistosoma mansoni ferritin light chain 0.0008 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0365 0.4681
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0084 0.0084
Brugia malayi nuclear receptor NHR-88 0.0009 0.0139 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Brugia malayi beta-lactamase family protein 0.0035 0.078 0.2586
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0365 0.4588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0399 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0399 0.1323
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0139 0.0139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0795 0.0795
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0117 0.0213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0399 0.0399
Loa Loa (eye worm) beta-lactamase 0.0035 0.078 0.2586
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.078 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0616 0.2044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0068 0.0875
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0084 0.0084
Mycobacterium ulcerans hypothetical protein 0.0035 0.078 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0139 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0399 0.0399
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0365 1
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0139 0.0139
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.078 0.1423
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.078 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0167 0.0554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1015 0.1015
Mycobacterium tuberculosis Conserved protein 0.0035 0.078 0.1423
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0365 0.4681
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0795 0.0795
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.078 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0399 0.0399
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0167 0.0167
Echinococcus granulosus tar DNA binding protein 0.0125 0.3015 0.3015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0127 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0399 0.1323
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0399 0.1323
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Schistosoma mansoni hypothetical protein 0.0408 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0399 0.0399
Brugia malayi CXXC zinc finger family protein 0.0029 0.0616 0.2044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1015 0.3368
Echinococcus granulosus ferritin 0.0008 0.0117 0.0117
Schistosoma mansoni ap endonuclease 0.0018 0.0365 0.0365
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0139 0.0462
Brugia malayi TAR-binding protein 0.0125 0.3015 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1015 0.1015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0139 0.1787
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0139 0.0139
Mycobacterium tuberculosis Conserved protein 0.0035 0.078 0.1423
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0399 0.1323
Echinococcus multilocularis cpg binding protein 0.003 0.0657 0.0657
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.3015 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3015 0.3015
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0117 0.0213
Brugia malayi steroid hormone receptor 0.002 0.0399 0.1323
Onchocerca volvulus 0.0035 0.078 1
Onchocerca volvulus 0.002 0.0399 0.5115
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5479 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Loa Loa (eye worm) hypothetical protein 0.001 0.0167 0.0554
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0399 0.0399
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0365 0.0365
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0399 0.1323
Entamoeba histolytica hypothetical protein 0.0036 0.0795 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Echinococcus multilocularis expressed protein 0.0008 0.0117 0.0117
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0365 0.4681
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0399 0.0399
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0035 0.078 0.2586
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0139 0.0139
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0139 0.0462
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0117 0.3202
Plasmodium vivax hypothetical protein, conserved 0.0035 0.078 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3015 0.3015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0365 0.4681
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0139 0.0139
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0399 0.0399
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0365 0.4681
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0139 0.0139
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0124 0.0412
Onchocerca volvulus 0.0009 0.0139 0.1787
Loa Loa (eye worm) RNA binding protein 0.0125 0.3015 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1411 0.1411
Loa Loa (eye worm) hypothetical protein 0.0035 0.078 0.2586
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0167 0.0554
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0399 0.1323
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0167 0.0554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0399 0.1323
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0399 0.0399
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0068 0.0875
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0399 0.0399
Mycobacterium tuberculosis Conserved protein 0.0035 0.078 0.1423
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0399 0.0399
Schistosoma mansoni nuclear receptor 0.0009 0.0139 0.0139
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0139 0.0462
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0139 0.0462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1015 0.1015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.078 0.1423
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0365 0.0666
Schistosoma mansoni thyroid hormone receptor 0.002 0.0399 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1015 0.1015
Mycobacterium leprae Probable lipase LipE 0.0035 0.078 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0399 0.1323
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.078 0.2586
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0167 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0365 0.4681
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0399 0.1323
Brugia malayi ecdysone receptor 0.0009 0.0139 0.0462
Loa Loa (eye worm) hypothetical protein 0.002 0.0399 0.1323
Schistosoma mansoni coup transcription factor 0.002 0.0399 0.0399
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1015 0.1015
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.078 1
Brugia malayi ecdysteroid receptor 0.002 0.0399 0.1323
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0365 0.1211
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0139 0.0139
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.078 0.078
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0139 0.0139
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0399 0.1323
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0399 0.1323
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0399 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0399 0.1323
Echinococcus granulosus cpg binding protein 0.003 0.0657 0.0657
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0139 0.1787
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Schistosoma mansoni ferritin 0.0008 0.0117 0.0117
Echinococcus granulosus expressed protein 0.0008 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0139 0.0462
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0068 0.0875
Brugia malayi nuclear receptor RXR 0.001 0.0167 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0399 0.1323
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0084 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1015 0.1015
Brugia malayi beta-lactamase family protein 0.0035 0.078 0.2586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0399 0.0399
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.078 0.1423
Toxoplasma gondii ABC1 family protein 0.0035 0.078 0.6236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.078 0.1423
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0399 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0399 0.1323
Mycobacterium ulcerans lipase LipD 0.0035 0.078 1
Brugia malayi hypothetical protein 0.001 0.0167 0.0554
Schistosoma mansoni ferritin light chain 0.0008 0.0117 0.0117
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.078 0.2586
Entamoeba histolytica hypothetical protein 0.0036 0.0795 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0399 0.0399
Loa Loa (eye worm) TAR-binding protein 0.0125 0.3015 1
Brugia malayi hypothetical protein 0.001 0.0167 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0399 0.1323
Brugia malayi beta-lactamase 0.0035 0.078 0.2586
Brugia malayi nuclear receptor NHR-88 0.002 0.0399 0.1323
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.078 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0068 0.0875
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0399 0.5115
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.078 0.1423
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0399 0.0399
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3015 0.3015
Brugia malayi hypothetical protein 0.0009 0.0139 0.0462
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.001 0.0167 0.0554
Schistosoma mansoni ap endonuclease 0.0018 0.0365 0.0365

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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