Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0112 | 0.5884 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0103 | 0.5349 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0112 | 0.5884 | 0.5 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0112 | 0.5884 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0112 | 0.5884 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0112 | 0.5884 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0112 | 0.5884 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.9298 | 1 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0167 | 0.0313 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0103 | 0.5349 | 0.5 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0103 | 0.5349 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0381 | 0.0381 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0103 | 0.5349 | 0.5349 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0103 | 0.5349 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0112 | 0.5884 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0214 | 0.04 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0103 | 0.5349 | 1 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0167 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0214 | 0.0214 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0103 | 0.5349 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0034 | 0.1334 | 0.0142 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0103 | 0.5349 | 0.5349 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0381 | 0.0713 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0103 | 0.5349 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0103 | 0.5349 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 1 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0036 | 0.1427 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0214 | 0.04 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0167 | 0.0313 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0167 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0381 | 0.0381 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0103 | 0.5349 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0381 | 0.0713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.