Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0152 | 0.1449 | 0.1392 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0314 | 0.44 | 0.4362 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0078 | 0.0105 | 0.009 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.0105 | 0.0038 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0076 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0152 | 0.1449 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.705 | 0.703 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0184 | 0.2042 | 0.1988 |
Echinococcus granulosus | acetylcholinesterase | 0.0447 | 0.681 | 0.681 |
Trichomonas vaginalis | hypothetical protein | 0.0184 | 0.2042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.4296 | 0.4258 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.7246 | 0.7228 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0447 | 0.681 | 0.6789 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.0105 | 0.0038 |
Echinococcus multilocularis | neuroligin | 0.0076 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0447 | 0.681 | 0.6789 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0424 | 0.6395 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0184 | 0.2042 | 0.1988 |
Schistosoma mansoni | neprilysin | 0.0162 | 0.1646 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.7246 | 0.7228 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0447 | 0.681 | 0.681 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.681 | 0.6789 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0577 | 0.9181 | 0.9181 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0152 | 0.1449 | 0.1392 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0424 | 0.6395 | 0.5 |
Onchocerca volvulus | 0.0308 | 0.4296 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.705 | 0.703 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0314 | 0.44 | 0.4362 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0076 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.2631 | 0.2581 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.0105 | 0.0038 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0424 | 0.6395 | 0.637 |
Onchocerca volvulus | 0.0078 | 0.0105 | 0.009 | |
Loa Loa (eye worm) | hypothetical protein | 0.0623 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1646 | 0.159 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.0105 | 0.0038 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0623 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1646 | 0.159 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0314 | 0.44 | 0.4362 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.0105 | 0.0038 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0184 | 0.2042 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.681 | 0.6789 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0184 | 0.2042 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0577 | 0.9181 | 0.9181 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.7246 | 0.7228 |
Echinococcus granulosus | acetylcholinesterase | 0.0447 | 0.681 | 0.681 |
Echinococcus multilocularis | peroxidasin | 0.0078 | 0.0105 | 0.0105 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0076 | 0.0067 | 0.0067 |
Echinococcus granulosus | neuroligin | 0.0076 | 0.0067 | 0.0067 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 0.0105 | 0.009 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0162 | 0.1646 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.7246 | 0.7228 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0424 | 0.6395 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 0.0105 | 0.009 |
Loa Loa (eye worm) | carboxylesterase | 0.0447 | 0.681 | 0.6789 |
Brugia malayi | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1646 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 0.6395 | 0.637 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0623 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0078 | 0.0105 | 0.0038 |
Toxoplasma gondii | peptidase family M13 protein | 0.0623 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0447 | 0.681 | 0.681 |
Onchocerca volvulus | 0.0078 | 0.0105 | 0.009 | |
Brugia malayi | peptidase family M13 containing protein | 0.0152 | 0.1449 | 0.1392 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1646 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.7246 | 0.7228 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1646 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.7246 | 0.7228 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.705 | 0.703 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0076 | 0.0067 | 0.0067 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0314 | 0.44 | 0.4362 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.046 | 0.705 | 0.703 |
Treponema pallidum | ATP-binding protein (ylxH-1) | 0.0428 | 0.6476 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0076 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0447 | 0.681 | 0.6789 |
Onchocerca volvulus | Peroxidasin homolog | 0.0078 | 0.0105 | 0.009 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0152 | 0.1449 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0623 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0447 | 0.681 | 0.681 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.705 | 0.703 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0152 | 0.1449 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Brugia malayi | Blistered cuticle protein 3 | 0.0078 | 0.0105 | 0.0038 |
Echinococcus granulosus | peroxidasin | 0.0078 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Onchocerca volvulus | Peroxidase homolog | 0.0078 | 0.0105 | 0.009 |
Brugia malayi | Peroxidasin | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Brugia malayi | Carboxylesterase family protein | 0.0447 | 0.681 | 0.6789 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.046 | 0.705 | 0.703 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0078 | 0.0105 | 0.0038 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0152 | 0.1449 | 0.1392 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0184 | 0.2042 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0623 | 1 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0623 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0623 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0076 | 0.0067 | 0.0067 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0623 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0623 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0078 | 0.0105 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0078 | 0.0105 | 0.0038 |
Echinococcus multilocularis | acetylcholinesterase | 0.0447 | 0.681 | 0.681 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0623 | 1 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0314 | 0.44 | 0.4362 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.1646 | 0.159 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0184 | 0.2042 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0078 | 0.0105 | 0.0038 |
Brugia malayi | Animal haem peroxidase family protein | 0.0078 | 0.0105 | 0.0038 |
Onchocerca volvulus | 0.0078 | 0.0105 | 0.009 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0152 | 0.1449 | 0.1392 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0105 | 0.0038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.71 uM | AntiHIV-1 activity measured in MT-4 cells at 5 to 6 different concentrations, using the reverse transcriptase (RT) assay | ChEMBL. | 1695683 |
EC50 (functional) | = 0.73 uM | AntiHIV-1 activity measured in MT-4 cells at 5 to 6 different concentrations, using the P24 antigen enzyme-linked immunosorbent assay (ELISA). | ChEMBL. | 1695683 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.