TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 277.317 | Formula: C18H15NO2
H donors: 0 H acceptors: 1 LogP: 3.49 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)/C=N/c1ccc2c(c1)oc(=O)cc2C
InChi: 1S/C18H15NO2/c1-12-3-5-14(6-4-12)11-19-15-7-8-16-13(2)9-18(20)21-17(16)10-15/h3-11H,1-2H3/b19-11+
InChiKey: PHHMKHIUFUOBAA-YBFXNURJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	mbt repeat family protein	0.0052	0.1085	0.1375
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0237	0.0222
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0753	1
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.1085	0.1062
Echinococcus granulosus	lamin	0.0029	0.0446	0.0431
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0237	0.0222
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0192	0.0177
Loa Loa (eye worm)	mbt repeat family protein	0.0052	0.1085	0.1443
Brugia malayi	nuclear hormone receptor	0.0022	0.0237	0.0238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0237	0.0316
Echinococcus multilocularis	survival motor neuron protein 1	0.0245	0.6589	0.6584
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0963	0.0918
Loa Loa (eye worm)	inositol-1	0.004	0.0753	0.1002
Echinococcus granulosus	dna polymerase kappa	0.002	0.0183	0.0168
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0237	0.0238
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0192	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0052	0.1085	0.9458
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0237	0.0064
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0059	0.1289	0.1276
Onchocerca volvulus		0.0053	0.1134	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0237	0.0238
Brugia malayi	intermediate filament protein	0.0029	0.0446	0.0518
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0753	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0183	0.0166
Schistosoma mansoni	coup transcription factor	0.0022	0.0237	0.0064
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0192	0.0177
Echinococcus multilocularis	lamin	0.0029	0.0446	0.0431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0963	0.0918
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0963	0.0918
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0222
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0192	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0963	0.0949
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0237	0.0238
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0237	0.0316
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0237	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0237	0.0238
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0237	0.0064
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0192	0.5
Brugia malayi	hypothetical protein	0.0245	0.6589	0.8751
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0237	0.0064
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0059	0.1289	0.1648
Brugia malayi	ecdysteroid receptor	0.0022	0.0237	0.0238
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0753	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0237	0.0222
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0237	0.0238
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0183	0.2365
Echinococcus granulosus	polycomb protein SCMH1	0.0052	0.1085	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0753	0.0739
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0237	0.0064
Echinococcus granulosus	dna polymerase eta	0.002	0.0183	0.0168
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0753	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0237	0.0064
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0963	0.0949
Brugia malayi	Inositol-1	0.004	0.0753	0.093
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0237	0.0238
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0446	0.0518
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0192	0.0196
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.0634	0.5
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0446	0.0309
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0237	0.0238
Echinococcus multilocularis	polycomb protein SCMH1	0.0052	0.1085	0.1072
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0237	0.0238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0237	0.0316
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0753	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0963	0.128
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0192	0.0155
Onchocerca volvulus		0.0029	0.0446	0.2324
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0059	0.0079
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0059	0.1289	0.1302
Schistosoma mansoni	survival motor neuron protein	0.005	0.1036	0.1005
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0237	0.0238
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0634	1
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0753	0.0739
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0237	0.0064
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0192	0.0155
Echinococcus granulosus	lamin dm0	0.0029	0.0446	0.0431
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.1036	0.1309
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0237	0.0222
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0052	0.1085	0.1062
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Echinococcus granulosus	SAM and MBT domain containing protein	0.0052	0.1085	0.1072
Echinococcus granulosus	intermediate filament protein	0.0029	0.0446	0.0431
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0446	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0029	0.043	0.0572
Brugia malayi	photoreceptor-specific nuclear receptor	0.0278	0.7521	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0183	0.0168
Trypanosoma brucei	unspecified product	0.002	0.0183	0.2365
Schistosoma mansoni	ap endonuclease	0.002	0.0192	0.001
Echinococcus granulosus	survival motor neuron protein 1	0.0245	0.6589	0.6584
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0183	0.0168
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0237	0.0064
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.1134	0.112
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0237	0.0064
Brugia malayi	steroid hormone receptor	0.0022	0.0237	0.0238
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0192	0.0155
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0237	0.0316
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0192	0.2483
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0237	0.0316
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0237	0.0222
Schistosoma mansoni	hypothetical protein	0.0318	0.8677	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0753	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0237	0.0064
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0237	0.0222
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0183	0.0243
Schistosoma mansoni	sex comb on midleg homolog	0.0052	0.1085	0.1062
Echinococcus multilocularis	dna polymerase eta	0.002	0.0183	0.0168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0963	0.0949
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0237	0.0222
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0059	0.1289	0.1276
Brugia malayi	mbt repeat family protein	0.0052	0.1085	0.1375
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0052	0.1085	0.1072
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0237	0.0222
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0753	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0183	0.2365
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0237	0.0238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0222
Schistosoma mansoni	inositol monophosphatase	0.004	0.0753	0.0671
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0237	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1134	0.1508
Schistosoma mansoni	hypothetical protein	0.005	0.1036	0.1005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0237	0.0316
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0208	0.553	0.5523
Loa Loa (eye worm)	MBCTL1	0.0059	0.1289	0.1714
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0237	0.0222
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0192	0.0155
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0237	0.0316
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0753	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0192	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0237	0.0222
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0237	0.0064
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0753	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0237	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0278	0.7521	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0237	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0237	0.0238
Echinococcus multilocularis	tumor protein p63	0.0365	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0183	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Onchocerca volvulus		0.0052	0.1085	0.9458
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Loa Loa (eye worm)	hypothetical protein	0.002	0.0183	0.0243
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0192	0.0155
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0183	0.2365
Schistosoma mansoni	lamin	0.0029	0.0446	0.0309
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0237	0.0238
Schistosoma mansoni	inositol monophosphatase	0.004	0.0753	0.0671
Onchocerca volvulus		0.005	0.1036	0.8913
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0753	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0237	0.0222
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0059	0.1289	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0237	0.0064
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0963	0.0949
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0192	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0245	0.6589	0.8761
Schistosoma mansoni	ap endonuclease	0.002	0.0192	0.001
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0237	0.0222
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0208	0.553	0.5523
Echinococcus granulosus	histone acetyltransferase MYST2	0.0059	0.1289	0.1276
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0183	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0446	0.0593
Onchocerca volvulus		0.0029	0.0446	0.2324
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0237	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1085	0.1443
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0183	0.2365
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0237	0.0222
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0192	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0963	0.1211
Echinococcus multilocularis	lamin dm0	0.0029	0.0446	0.0431
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0222
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0446	0.0593
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0237	0.0238
Schistosoma mansoni	lamin	0.0029	0.0446	0.0309
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0237	0.0064
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0192	0.0177
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0192	0.0255
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0183	0.2365
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1289	0.1714
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0753	1
Echinococcus multilocularis	musashi	0.0029	0.0446	0.0431

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 10 mm	Antibacterial activity against Escherichia coli NCIM 2666 at 100 ug/ml by agar cup plate method	ChEMBL.	19837487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL584407

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1085030