Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0315 | 0.0098 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.1111 | 0.0911 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0601 | 0.039 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.4162 | 0.4031 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.4433 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.022 | 0.0118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6701 | 0.6627 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.089 | 0.0685 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.022 | 0.0118 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.1111 | 0.1018 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0871 | 0.0666 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.1111 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6701 | 0.6667 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0601 | 0.039 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0315 | 0.0098 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0498 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.1111 | 0.1018 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1111 | 0.0911 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0498 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.022 | 0.0118 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0601 | 0.0503 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.6701 | 0.6627 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.1111 | 0.1018 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.6701 | 0.6627 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0498 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.1111 | 0.1018 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.9475 | 0.9469 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.1111 | 0.2261 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.1111 | 0.1018 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0601 | 0.039 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.1111 | 0.0911 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0498 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0498 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4162 | 0.4101 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.022 | 0.0118 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.1111 | 0.0911 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0601 | 0.039 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1111 | 0.0911 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.022 | 0.0118 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6701 | 0.6667 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.6701 | 0.6667 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.1111 | 0.1018 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1111 | 0.0911 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1111 | 0.0911 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.1111 | 0.0911 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0498 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1111 | 0.0911 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0315 | 0.0214 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6701 | 0.6627 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.6701 | 0.6627 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.1111 | 0.0911 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.1111 | 0.2261 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.022 | 0.0118 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.1111 | 0.1018 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.4433 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.089 | 0.0685 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4433 | 0.4374 |
Onchocerca volvulus | 0.0029 | 0.4162 | 1 | |
Onchocerca volvulus | 0.001 | 0.1111 | 0.2261 | |
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0315 | 0.0098 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.1111 | 0.1018 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0315 | 0.0214 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0498 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.1111 | 0.1018 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0498 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1111 | 0.1018 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0315 | 0.0098 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.022 | 0.0118 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4433 | 0.4374 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.1111 | 0.0911 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.1111 | 0.2261 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0315 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.1111 | 0.1018 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.1111 | 0.0911 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.089 | 0.0685 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.4162 | 0.4031 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1111 | 0.1018 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1111 | 0.0911 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.8401 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0498 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.1111 | 0.0911 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.6701 | 0.6627 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0498 | 1 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.1111 | 0.0911 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1111 | 0.0911 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.1111 | 0.0911 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0315 | 0.0098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.1111 | 0.0911 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.022 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1111 | 0.0911 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0315 | 0.0098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.