TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.963 | Formula: C24H27ClN6O2
H donors: 3 H acceptors: 2 LogP: 2.76 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)C)Nc1ccc(cc1)Cn1ncc(c(c1=O)Cl)N1CCNCCC1
InChi: 1S/C24H27ClN6O2/c1-17-3-7-19(8-4-17)28-24(33)29-20-9-5-18(6-10-20)16-31-23(32)22(25)21(15-27-31)30-13-2-11-26-12-14-30/h3-10,15,26H,2,11-14,16H2,1H3,(H2,28,29,33)
InChiKey: MWHUAFSENUXMPF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0325	0.0325
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.029	1
Schistosoma mansoni	tar DNA-binding protein	0.0145	0.2972	0.2972
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0215	0.0215
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0325	0.0325
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0123	0.2506	0.8862
Loa Loa (eye worm)	cytochrome P450 family protein	0.006	0.1124	0.369
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0325	0.0325
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.023	0.023
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0325	0.097
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0088	0.0088
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.067	0.2148
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.006	0.006
Plasmodium vivax	glutathione reductase, putative	0.0054	0.0999	1
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.006	0.0064
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0325	0.097
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0088	0.0161
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.029	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0325	0.0325
Mycobacterium tuberculosis	Probable reductase	0.0123	0.2506	0.8862
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0325	0.0325
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0011	0.006	0.0064
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0019	0.023	0.0673
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0011	0.006	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0325	0.097
Schistosoma mansoni	cpg binding protein	0.0033	0.0537	0.0537
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0325	0.0325
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0019	0.023	0.0673
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.029	0.0436
Leishmania major	trypanothione reductase	0.0054	0.0999	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0325	0.097
Brugia malayi	hypothetical protein	0.0012	0.0088	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Loa Loa (eye worm)	RNA binding protein	0.0145	0.2972	1
Echinococcus multilocularis	tar DNA binding protein	0.0145	0.2972	0.2972
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.006	0.006
Toxoplasma gondii	exonuclease III APE	0.0021	0.029	0.1147
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0011	0.006	0.006
Loa Loa (eye worm)	cytochrome P450	0.0016	0.0175	0.0448
Schistosoma mansoni	nuclear receptor nhr-48	0.0011	0.006	0.006
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0011	0.006	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.029	0.0772
Plasmodium falciparum	thioredoxin reductase	0.0054	0.0999	1
Schistosoma mansoni	ap endonuclease	0.0021	0.029	0.029
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0325	0.0325
Onchocerca volvulus		0.0056	0.1051	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0175	0.0457
Brugia malayi	Nuclear hormone receptor E75	0.0011	0.006	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Trypanosoma cruzi	trypanothione reductase, putative	0.0054	0.0999	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Brugia malayi	hypothetical protein	0.0011	0.006	0.0064
Toxoplasma gondii	NADPH-glutathione reductase	0.0019	0.023	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Schistosoma mansoni	zinc finger protein	0.0011	0.006	0.006
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.1063	0.3487
Loa Loa (eye worm)	TAR-binding protein	0.0145	0.2972	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0014	0.0122	0.0277
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.1176	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0011	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0145	0.2972	1
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0325	0.097
Onchocerca volvulus		0.0033	0.0537	0.4818
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0137	0.2806	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0019	0.023	0.0673
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0325	0.0961
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0215	0.0215
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0325	0.0325
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0011	0.006	0.0054
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0325	0.0325
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0325	0.0325
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0325	0.0325
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.1063	0.3487
Brugia malayi	Thioredoxin reductase	0.0054	0.0999	0.3269
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0325	0.0961
Brugia malayi	hypothetical protein	0.0011	0.006	0.0064
Brugia malayi	nuclear receptor RXR	0.0011	0.006	0.0064
Echinococcus multilocularis	nuclear receptor nhr 48	0.0011	0.006	0.006
Echinococcus granulosus	thyroid hormone receptor alpha	0.0011	0.006	0.006
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0011	0.006	0.006
Echinococcus granulosus	thioredoxin glutathione reductase	0.0054	0.0999	0.0999
Brugia malayi	TAR-binding protein	0.0145	0.2972	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0325	0.0325
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0325	0.0961
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0088	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0325	0.097
Schistosoma mansoni	cpg binding protein	0.0035	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1063	0.3481
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0019	0.023	0.0211
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.006	0.006
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0011	0.006	0.006
Loa Loa (eye worm)	nuclear hormone receptor	0.0011	0.006	0.0054
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0467	1	1
Brugia malayi	conserved hypotetical protein	0.0011	0.006	0.0064
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0088	0.0161
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.029	0.084
Loa Loa (eye worm)	hypothetical protein	0.0039	0.067	0.2141
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.1051	0.1051
Loa Loa (eye worm)	DR-78	0.0011	0.006	0.0054
Schistosoma mansoni	hypothetical protein	0.0018	0.0215	0.0215
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0088	0.0088
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0325	0.0325
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0019	0.023	0.4832
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0175	0.0448
Echinococcus granulosus	GPCR family 2	0.0018	0.0215	0.0215
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0325	0.097
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.029	0.1393
Schistosoma mansoni	nuclear receptor	0.0011	0.006	0.006
Mycobacterium tuberculosis	Probable oxidoreductase	0.0137	0.2806	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0088	0.0151
Schistosoma mansoni	hypothetical protein	0.0039	0.067	0.067
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0088	0.0088
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0215	0.0215
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0054	0.0999	0.3133
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.029	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0325	0.097
Brugia malayi	cytochrome P450	0.0016	0.0175	0.0457
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1338	0.1338
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0215	0.0215
Echinococcus granulosus	cpg binding protein	0.0035	0.0578	0.0578
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.006	0.006
Brugia malayi	orphan nuclear receptor NR2E1	0.0011	0.006	0.0064
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.029	0.1393
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0325	0.0325
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0137	0.2806	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0325	0.097
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0019	0.023	0.0554
Brugia malayi	nuclear receptor NHR-88	0.0011	0.006	0.0064
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0019	0.023	0.5
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0019	0.023	0.4832
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0325	0.0325
Echinococcus granulosus	tumor protein p63	0.0385	0.8214	0.8214
Schistosoma mansoni	ap endonuclease	0.0021	0.029	0.029
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0215	0.0215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.006	0.006
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.023	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1051	0.3439
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.029	0.0849
Echinococcus granulosus	tar DNA binding protein	0.0145	0.2972	0.2972
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0215	0.0585
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.1063	0.3481
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0325	0.097
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0537	0.1693
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.029	0.1393
Trypanosoma brucei	trypanothione reductase	0.0054	0.0999	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0325	0.0325
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0019	0.023	0.4832
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Schistosoma mansoni	hypothetical protein	0.0018	0.0215	0.0215
Brugia malayi	glutathione reductase	0.0054	0.0999	0.3269
Loa Loa (eye worm)	glutathione reductase	0.0054	0.0999	0.3263
Brugia malayi	steroid hormone receptor	0.0023	0.0325	0.097
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0325	0.0325
Brugia malayi	nuclear hormone receptor	0.0023	0.0325	0.097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0325	0.0961
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0123	0.2506	0.8862
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0054	0.0999	0.0999
Schistosoma mansoni	hypothetical protein	0.0018	0.0215	0.0215
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.029	0.029
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0011	0.006	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Brugia malayi	hypothetical protein	0.0012	0.0088	0.0161
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0088	0.0088
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0325	0.0325
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0325	0.2678
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0325	0.2678
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0325	0.0961
Toxoplasma gondii	thioredoxin reductase	0.0054	0.0999	0.823
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.023	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0088	0.0151
Brugia malayi	nuclear receptor RXR	0.0012	0.0088	0.0161
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0325	0.0325
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0137	0.2806	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0325	0.0325
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0325	0.0325
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.029	0.029
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0215	0.0594
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0011	0.006	0.006
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.029	0.0772
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0019	0.023	0.0673
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0325	0.0325
Mycobacterium tuberculosis	Probable dehydrogenase	0.0123	0.2506	0.8862
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0325	0.0325
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0325	0.097
Loa Loa (eye worm)	thioredoxin reductase	0.0054	0.0999	0.3263
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0325	0.097
Plasmodium falciparum	glutathione reductase	0.0054	0.0999	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0011	0.006	0.006
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0123	0.2506	0.8862
Schistosoma mansoni	nuclear receptor	0.0011	0.006	0.006
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.029	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.023	0.023
Echinococcus multilocularis	cpg binding protein	0.0035	0.0578	0.0578
Brugia malayi	nuclear hormone receptor family member odr-7	0.0011	0.006	0.0064
Brugia malayi	ecdysteroid receptor	0.0023	0.0325	0.097
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0325	0.0325
Onchocerca volvulus		0.0023	0.0325	0.2678
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.023	0.023
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0325	0.097
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0215	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0088	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0088	0.0151
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.006	0.006
Schistosoma mansoni	tar DNA-binding protein	0.0145	0.2972	0.2972
Schistosoma mansoni	tar DNA-binding protein	0.0145	0.2972	0.2972
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0325	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0215	0.0585
Echinococcus granulosus	cytochrome P450 2K1	0.0016	0.0175	0.0175
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.023	0.0673
Brugia malayi	RNA recognition motif domain containing protein	0.0145	0.2972	1
Schistosoma mansoni	cytochrome P450	0.0016	0.0175	0.0175
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.023	0.0673
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0325	0.0325
Brugia malayi	nuclear receptor NHR-67	0.0011	0.006	0.0064
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0325	0.0961
Brugia malayi	ecdysone receptor	0.0011	0.006	0.0064
Brugia malayi	nuclear hormone receptor	0.0011	0.006	0.0064
Plasmodium vivax	thioredoxin reductase, putative	0.0054	0.0999	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.023	0.0673
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.029	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0011	0.006	0.006
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.029	1
Brugia malayi	Cytochrome P450 family protein	0.006	0.1124	0.3697
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0325	0.097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Echinococcus multilocularis		0.0016	0.0175	0.0175
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0325	0.2678
Trypanosoma cruzi	trypanothione reductase, putative	0.0019	0.023	0.0673
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0325	0.097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0325	0.097
Echinococcus multilocularis	tumor protein p63	0.0385	0.8214	0.8214
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0018	0.0215	0.0215
Schistosoma mansoni	coup transcription factor	0.0023	0.0325	0.0325
Brugia malayi	tailless protein	0.0011	0.006	0.0064
Schistosoma mansoni	tar DNA-binding protein	0.0145	0.2972	0.2972
Brugia malayi	RNA binding protein	0.0145	0.2972	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0325	0.0961
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0537	0.1685
Schistosoma mansoni	cpg binding protein	0.0035	0.0578	0.0578
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0325	0.0325
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.029	0.1393
Schistosoma mansoni	hypothetical protein	0.0016	0.0175	0.0175
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0014	0.0122	0.0277
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0175	0.0457
Schistosoma mansoni	tar DNA-binding protein	0.0145	0.2972	0.2972
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0175	0.0457
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0123	0.2506	0.8862
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0325	0.097
Echinococcus multilocularis	dnaJ subfamily B	0.0467	1	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.023	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0011	0.006	0.0054
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0123	0.2506	0.8862
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0325	0.0961
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0175	0.0448
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0175	0.0448
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.029	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0088	0.0151
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0325	0.0325

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL588073

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1085431