Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0231 | 0.0679 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0287 | 0.3322 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0858 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1095 | 0.4348 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0858 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0287 | 0.3322 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0287 | 0.3322 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0141 | 0.0559 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0858 | 0.341 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0141 | 0.0242 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0858 | 0.0856 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0858 | 0.2349 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0858 | 0.341 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0002 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0858 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0858 | 0.4033 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0858 | 0.0856 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0858 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0858 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0858 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0287 | 0.0284 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0858 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.1994 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0858 | 0.341 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0287 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2517 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0858 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0858 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0344 | 0.0234 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.1994 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0867 | 0.4076 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0009 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0858 | 0.2349 |
Onchocerca volvulus | 0.0036 | 0.0858 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0858 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0858 | 0.341 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0287 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0858 | 0.0856 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0287 | 0.3322 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0858 | 0.0856 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0867 | 0.4076 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0858 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.272 | 1 |
Onchocerca volvulus | 0.0036 | 0.0858 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1185 | 0.4709 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0287 | 0.3322 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0287 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0009 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0858 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0858 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0858 | 0.341 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0231 | 0.0739 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0858 | 0.3702 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0858 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0287 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0002 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0231 | 0.0739 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0287 | 0.3322 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0858 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0858 | 0.3702 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0858 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0009 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0858 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0287 | 0.0284 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0858 | 0.341 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0009 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0858 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0287 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0858 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0982 | 0.3902 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0287 | 0.3322 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0858 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0858 | 0.2349 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0858 | 0.341 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0858 | 0.341 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2164 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0858 | 0.0856 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0858 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0287 | 0.3322 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0858 | 0.0856 |
Onchocerca volvulus | 0.0036 | 0.0858 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0858 | 0.2349 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0858 | 0.0856 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0979 | 0.2845 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0858 | 0.4033 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0858 | 0.0856 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0287 | 0.1139 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 32.7 uM | Inhibition of Mycobacterium tuberculosis recombinant DXR expressed in Escherichia coli BL21 (DE3) using DXP as substrate and MgCl2 as cofactor preincubated for 10 mins | ChEMBL. | 21561155 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.