TDR Targets

Basic information

Technical information

TDR Targets ID: 1085690
Name: (E)-1-bromo-3,7,11,15-tetramethylhexadec-2-en e
MW: 359.428 | Formula: C20H39Br
H donors: 0 H acceptors: 0 LogP: 9.63 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: BrC/C=C(/CCCC(CCCC(CCCC(C)C)C)C)\C
InChi: 1S/C20H39Br/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h15,17-19H,6-14,16H2,1-5H3/b20-15+
InChiKey: KQYUEKLNYFZILD-HMMYKYKNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-1-bromo-3,7,11,15-tetramethyl-hexadec-2-ene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0497	0.1019
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0777	0.1593
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.4878	0.4878
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0	0.5
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0308	0.0308
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0308	0.0631
Brugia malayi	steroid hormone receptor	0.001	0.0308	0.0631
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0777	0.0777
Onchocerca volvulus		0.0026	0.1742	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0308	0.0631
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0007	0	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.336	0.336
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0308	0.0631
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0308	0.0631
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0777	0.1593
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0663	0.1359
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.4878	0.4878
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.4878	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0308	0.0631
Entamoeba histolytica	aldehyde-alcohol dehydrogenase 2, putative	0.0007	0	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.012	1	1
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0007	0	0.5
Onchocerca volvulus		0.0026	0.1742	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0308	0.0631
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0308	0.0308
Brugia malayi	RNA binding protein	0.0062	0.4878	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0308	0.1768
Brugia malayi	intermediate filament protein	0.0026	0.1742	0.3572
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.336	0.336
Schistosoma mansoni	hypothetical protein	0.0015	0.0777	0.0777
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Trichomonas vaginalis	succinate semialdehyde dehydrogenase, putative	0.0007	0	0.5
Trypanosoma cruzi	aldehyde dehydrogenase family, putative	0.0007	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0308	0.0631
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.336	0.336
Trypanosoma cruzi	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0	0.5
Wolbachia endosymbiont of Brugia malayi	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase	0.0007	0	0.5
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.012	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0308	0.0631
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0308	0.0631
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1742	0.3572
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0308	0.0631
Trypanosoma cruzi	aldehyde dehydrogenase family, putative	0.0007	0	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0777	0.1593
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0308	0.0631
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.012	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.4878	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0308	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0033	0.2355	0.4828
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.4878	0.4878
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0308	0.0631
Schistosoma mansoni	hypothetical protein	0.0015	0.0777	0.0777
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0308	0.0631
Entamoeba histolytica	aldehyde-alcohol dehydrogenase 2, putative	0.0007	0	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0777	0.0777
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0049	0.3714	0.7615
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.336	0.6889
Brugia malayi	TAR-binding protein	0.0062	0.4878	1
Brugia malayi	ecdysteroid receptor	0.001	0.0308	0.0631
Trypanosoma brucei	aldehyde dehydrogenase family, putative	0.0007	0	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.1742	0.3572
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.4878	0.4878
Trypanosoma cruzi	pyrroline-5-carboxylate synthetase-like protein, putative	0.0007	0	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0308	0.1768
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0308	0.0308
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	1	1
Echinococcus granulosus	GPCR family 2	0.0015	0.0777	0.0777
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0308	0.0308
Onchocerca volvulus		0.001	0.0308	0.1768
Trypanosoma cruzi	pyrroline-5-carboxylate synthetase-like protein, putative	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0308	0.0308
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.4878	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	1	1
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0	0.5
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0	0.5
Toxoplasma gondii	aldehyde dehydrogenase	0.012	1	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0497	0.1019
Trypanosoma brucei	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0	0.5
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0539	0.0539
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.336	0.336
Entamoeba histolytica	aldehyde-alcohol dehydrogenase 2, putative	0.0007	0	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.3714	0.7615
Brugia malayi	nuclear hormone receptor	0.001	0.0308	0.0631
Schistosoma mansoni	hypothetical protein	0.0033	0.2355	0.2355
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0539	0.1106
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0308	0.0308
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0777	0.0777
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0777	0.0777
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0308	0.0308
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0308	0.0631
Treponema pallidum	gamma-glutamyl phosphate reductase	0.0007	0	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.2355	0.4828
Trypanosoma cruzi	aldehyde dehydrogenase family, putative	0.0007	0	0.5
Loa Loa (eye worm)	RNA binding protein	0.0062	0.4878	1
Mycobacterium leprae	PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT	0.0007	0	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0777	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0026	0.17	0.3484
Echinococcus granulosus	lamin dm0	0.0026	0.1742	0.1742
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0308	0.0631
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0308	0.0631
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.336	0.6889
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0308	0.0308
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0777	0.0777
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0308	0.0308
Trypanosoma cruzi	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0	0.5
Echinococcus multilocularis	lamin	0.0026	0.1742	0.1742
Echinococcus granulosus	lamin	0.0026	0.1742	0.1742
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0308	0.0631
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0308	0.0631
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0308	0.0308
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.1742	0.3572
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0308	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0777	0.1593
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0308	0.0308
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.3714	0.7615
Schistosoma mansoni	coup transcription factor	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0308	0.0631
Echinococcus multilocularis	lamin dm0	0.0026	0.1742	0.1742
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0308	0.0308
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.4878	0.4878
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0308	0.0308
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.012	1	1
Trypanosoma brucei	aldehyde dehydrogenase family, putative	0.0007	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0308	0.0308
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0308	0.0631
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0308	0.0308
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0308	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0308	0.0631
Schistosoma mansoni	lamin	0.0026	0.1742	0.1742
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0308	0.0308
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0007	0	0.5
Echinococcus granulosus	intermediate filament protein	0.0026	0.1742	0.1742
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0308	0.0631
Schistosoma mansoni	lamin	0.0026	0.1742	0.1742
Entamoeba histolytica	aldehyde dehydrogenase 1, putative	0.0007	0	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0308	0.0308
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0308	0.1768
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.1742	0.3572
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0308	0.0308
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.4878	0.4878
Echinococcus granulosus	tar DNA binding protein	0.0062	0.4878	0.4878
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0308	0.0308
Mycobacterium leprae	PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE	0.0007	0	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.336	0.336
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0308	0.0308
Echinococcus multilocularis	musashi	0.0026	0.1742	0.1742
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0308	0.0308
Schistosoma mansoni	intermediate filament proteins	0.0026	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Schistosoma mansoni	aldehyde dehydrogenase	0.012	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.336	0.336
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0308	0.0631
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0663	0.1359
Giardia lamblia	Alcohol dehydrogenase	0.0007	0	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.336	0.336
Schistosoma mansoni	hypothetical protein	0.0015	0.0777	0.0777
Loa Loa (eye worm)	hypothetical protein	0.001	0.0308	0.0631
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.3714	0.7615

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL593772

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1085690